Bringing Intrinsically Disordered Proteins to Biomedical Applications

Project Information

IDP2Biomed

Grant agreement ID: 101160233

DOI

10.3030/101160233

EC signature date 9 May 2024

Start date 1 October 2024

End date 30 September 2027

Funded under

• Widening participation and spreading excellence

Total cost

No data

EU contribution

€ 1 244 706,00

Coordinated by

EOTVOS LORAND TUDOMANYEGYETEM
Hungary

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Data Management Plan (1)

Data Management Plan

Websites, patent fillings, videos etc. (2)

Launch of the IDP2Biomed HUB
Launch of the IDP2Biomed website and links to social media, Communication toolkit

Launch of the IDP2Biomed website and links to social media, communication toolkit

Documents, reports (2)

Detailed Dissemination, Communication, Outreach and Exploitation Plan (DCOP) (Lead: ELTE)
Report on state-of-the art of characterizing conformational states of IDPs

Publications

Peer reviewed articles (12)

AIUPred - Binding: energy embedding to identify disordered binding regions

Author(s): Gábor Erdős, Norbert Deutsch, Zsuzsanna Dosztányi
Published in: Journal of Molecular Biology, 2025, ISSN 0022-2836
Publisher: Elsevier BV
DOI: 10.1016/J.JMB.2025.169071

Towards a Unified Framework for Determining Conformational Ensembles of Disordered Proteins

Author(s): Hamidreza Ghafouri, Pavel Kadeřávek, Ana M Melo, Maria Cristina Aspromonte, Pau Bernadó, Juan Cortes, Zsuzsanna Dosztányi, Gabor Erdos, Michael Feig, Giacomo Janson, Kresten Lindorff-Larsen, Frans A. A. Mulder, Peter Nagy, Richard Pestell, Damiano Piovesa
Published in: arXiv, 2025, ISSN 2331-8422
Publisher: Cornell University
DOI: 10.48550/ARXIV.2504.03590

DisProt in 2026: enhancing intrinsically disordered proteins accessibility, deposition, and annotation

Author(s): Maria Victoria Nugnes, Kamel Eddine Adel Bouhraoua, Mehdi Zoubiri, Rita Pancsa, Erzsébet Fichó, null null, Alexander M Monzon, Ana M Melo, Edoardo Salladini, Emanuela Leonardi, Federica Quaglia, Daniyal Nasiribavil, Hamidreza Ghafouri, Gobeill Julien, Emilie Pasche, Patrick Ruch, Paul Van Rijen, László Dobson, Marco Schiavina, Trinidad Cordero, Zsófia E Kálmán, Ximena Castro, Valentín Iglesias, István Reményi, Mahta Mehdiabadi, Gábor Erdős, Zsuzsanna Dosztányi, Peter Tompa, Damiano Piovesan, Silvio C E Tosatto, Maria Cristina Aspromonte
Published in: Nucleic Acids Research, Issue 54, 2026, ISSN 0305-1048
Publisher: Oxford University Press (OUP)
DOI: 10.1093/NAR/GKAF1175

Selective engineering of condensation properties of single-stranded DNA binding (SSB) protein via its intrinsically disordered linker region

Author(s): Péter Ecsédi; Dávid Érfalvy; Zoltán J Kovács; Viktoria Katran; János Pálinkás; Miklós Cervenak; Rita Pancsa; Gábor M Harami; László Smeller; Mihály Kovács
Published in: Nucleic Acids Research, 2025, ISSN 1362-4962
Publisher: Oxford University Press
DOI: 10.1093/NAR/GKAF481

Fine‐tuned interactions between globular and disordered regions of single‐stranded <scp>DNA</scp> binding (<scp>SSB</scp>) protein are required for dynamic condensation under physiological conditions

Author(s): Zoltán J. Kovács; Péter Ecsédi; Gábor M. Harami; János Pálinkás; Mina Botros; Lamiya Mahmudova; Viktoria Katran; Dávid Érfalvy; Miklós Cervenak; László Smeller; Mihály Kovács
Published in: Protein Science, 2025, ISSN 1613-6829
Publisher: Wiley
DOI: 10.1002/PRO.70109

<scp>DR</scp> and <scp>SPIT</scp>: Statistical approaches for identifying transient structure in intrinsically disordered proteins via <scp>NMR</scp> chemical shifts

Author(s): Dániel Kovács; Andrea Bodor
Published in: Protein Science, 2025, ISSN 1469-896X
Publisher: Wiley-Blackwel
DOI: 10.1002/PRO.70250

MOBIDB in 2025: integrating ensemble properties and function annotations for intrinsically disordered proteins

Author(s): Damiano Piovesan; Alessio Del Conte; Mahta Mehdiabadi; Maria Cristina Aspromonte; Matthias Blum; Giulio Tesei; Sören von Bülow; Kresten Lindorff-Larsen; Silvio C E Tosatto
Published in: Nucleic Acids Research, 2024, ISSN 1362-4962
Publisher: Oxford University Press
DOI: 10.1093/NAR/GKAE969

Phase transition drives bacterial single-stranded DNA binding (SSB) protein mobilization during stress response and metabolic adaptation

Author(s): Péter Ecsédi1 , Júlia Szittyai1 , János Pálinkás1,2, Bálint Jezsó1,2, Viktoria Katran1 , Zoltán J. Kovács1,2, Henriett Halász3 , Tasvilla Sonallya4 , Tünde Juhász4 , Tamás Beke-Somfai4 , Szilvia Barkó3 , Edina Szabó-Meleg3 , and Mihály Kovács1,2
Published in: bioRxiv, 2025, ISSN 2692-8205
Publisher: bioRxiv
DOI: 10.1101/2025.08.28.672810V1

DRMAAtic: dramatically improve your cluster potential

Author(s): Del Conte, Alessio; Ghafouri, Hamidreza; Clementel, Damiano; Mičetić, Ivan; Piovesan, Damiano; Tosatto, Silvio C E; Monzon, Alexander Miguel
Published in: Bioinformatics Advances, 2024, ISSN 2635-0041
Publisher: Oxford University Press
DOI: 10.1093/BIOADV/VBAF112

GeomeTRe: accurate calculation of geometrical descriptors of tandem repeat proteins

Author(s): Osmanli, Zarifa; Ferrero, Elisa; Monzon, Alexander Miguel; Tosatto, Silvio C E; Piovesan, Damiano
Published in: Bioinformatics, 2025, ISSN 1367-4811
Publisher: Oxford Academic
DOI: 10.1093/BIOINFORMATICS/BTAF395

Deep learning for intrinsically disordered proteins: From improved predictions to deciphering conformational ensembles

Author(s): Gábor Erdős, Zsuzsanna Dosztányi
Published in: Current Opinion in Structural Biology, Issue 89, 2024, ISSN 0959-440X
Publisher: Elsevier BV
DOI: 10.1016/j.sbi.2024.102950

Critical Assessment of Protein Intrinsic Disorder Round 3 ‐ Predicting Disorder in the Era of Protein Language Models

Author(s): Mahta Mehdiabadi, Alessio Del Conte, Maria Victoria Nugnes, Maria Cristina Aspromonte, Silvio C. E. Tosatto, Damiano Piovesan
Published in: Proteins: Structure, Function, and Bioinformatics, 2025, ISSN 0887-3585
Publisher: Wiley
DOI: 10.1002/PROT.70045