Bringing Intrinsically Disordered Proteins to Biomedical Applications

Informazioni relative al progetto

IDP2Biomed

ID dell’accordo di sovvenzione: 101160233

DOI

10.3030/101160233

Data della firma CE 9 Maggio 2024

Data di avvio 1 Ottobre 2024

Data di completamento 30 Settembre 2027

Finanziato da

• Widening participation and spreading excellence

Costo totale

Nessun dato

Contributo UE

€ 1 244 706,00

Coordinato da

EOTVOS LORAND TUDOMANYEGYETEM
Hungary

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Data Management Plan (1)

Data Management Plan

Websites, patent fillings, videos etc. (2)

Launch of the IDP2Biomed HUB
Launch of the IDP2Biomed website and links to social media, Communication toolkit

Launch of the IDP2Biomed website and links to social media, communication toolkit

Documents, reports (2)

Detailed Dissemination, Communication, Outreach and Exploitation Plan (DCOP) (Lead: ELTE)
Report on state-of-the art of characterizing conformational states of IDPs

Pubblicazioni

Peer reviewed articles (12)

AIUPred - Binding: energy embedding to identify disordered binding regions

Autori: Gábor Erdős, Norbert Deutsch, Zsuzsanna Dosztányi
Pubblicato in: Journal of Molecular Biology, 2025, ISSN 0022-2836
Editore: Elsevier BV
DOI: 10.1016/J.JMB.2025.169071

Towards a Unified Framework for Determining Conformational Ensembles of Disordered Proteins

Autori: Hamidreza Ghafouri, Pavel Kadeřávek, Ana M Melo, Maria Cristina Aspromonte, Pau Bernadó, Juan Cortes, Zsuzsanna Dosztányi, Gabor Erdos, Michael Feig, Giacomo Janson, Kresten Lindorff-Larsen, Frans A. A. Mulder, Peter Nagy, Richard Pestell, Damiano Piovesa
Pubblicato in: arXiv, 2025, ISSN 2331-8422
Editore: Cornell University
DOI: 10.48550/ARXIV.2504.03590

DisProt in 2026: enhancing intrinsically disordered proteins accessibility, deposition, and annotation

Autori: Maria Victoria Nugnes, Kamel Eddine Adel Bouhraoua, Mehdi Zoubiri, Rita Pancsa, Erzsébet Fichó, null null, Alexander M Monzon, Ana M Melo, Edoardo Salladini, Emanuela Leonardi, Federica Quaglia, Daniyal Nasiribavil, Hamidreza Ghafouri, Gobeill Julien, Emilie Pasche, Patrick Ruch, Paul Van Rijen, László Dobson, Marco Schiavina, Trinidad Cordero, Zsófia E Kálmán, Ximena Castro, Valentín Iglesias, István Reményi, Mahta Mehdiabadi, Gábor Erdős, Zsuzsanna Dosztányi, Peter Tompa, Damiano Piovesan, Silvio C E Tosatto, Maria Cristina Aspromonte
Pubblicato in: Nucleic Acids Research, Numero 54, 2026, ISSN 0305-1048
Editore: Oxford University Press (OUP)
DOI: 10.1093/NAR/GKAF1175

Selective engineering of condensation properties of single-stranded DNA binding (SSB) protein via its intrinsically disordered linker region

Autori: Péter Ecsédi; Dávid Érfalvy; Zoltán J Kovács; Viktoria Katran; János Pálinkás; Miklós Cervenak; Rita Pancsa; Gábor M Harami; László Smeller; Mihály Kovács
Pubblicato in: Nucleic Acids Research, 2025, ISSN 1362-4962
Editore: Oxford University Press
DOI: 10.1093/NAR/GKAF481

Fine‐tuned interactions between globular and disordered regions of single‐stranded <scp>DNA</scp> binding (<scp>SSB</scp>) protein are required for dynamic condensation under physiological conditions

Autori: Zoltán J. Kovács; Péter Ecsédi; Gábor M. Harami; János Pálinkás; Mina Botros; Lamiya Mahmudova; Viktoria Katran; Dávid Érfalvy; Miklós Cervenak; László Smeller; Mihály Kovács
Pubblicato in: Protein Science, 2025, ISSN 1613-6829
Editore: Wiley
DOI: 10.1002/PRO.70109

<scp>DR</scp> and <scp>SPIT</scp>: Statistical approaches for identifying transient structure in intrinsically disordered proteins via <scp>NMR</scp> chemical shifts

Autori: Dániel Kovács; Andrea Bodor
Pubblicato in: Protein Science, 2025, ISSN 1469-896X
Editore: Wiley-Blackwel
DOI: 10.1002/PRO.70250

MOBIDB in 2025: integrating ensemble properties and function annotations for intrinsically disordered proteins

Autori: Damiano Piovesan; Alessio Del Conte; Mahta Mehdiabadi; Maria Cristina Aspromonte; Matthias Blum; Giulio Tesei; Sören von Bülow; Kresten Lindorff-Larsen; Silvio C E Tosatto
Pubblicato in: Nucleic Acids Research, 2024, ISSN 1362-4962
Editore: Oxford University Press
DOI: 10.1093/NAR/GKAE969

Phase transition drives bacterial single-stranded DNA binding (SSB) protein mobilization during stress response and metabolic adaptation

Autori: Péter Ecsédi1 , Júlia Szittyai1 , János Pálinkás1,2, Bálint Jezsó1,2, Viktoria Katran1 , Zoltán J. Kovács1,2, Henriett Halász3 , Tasvilla Sonallya4 , Tünde Juhász4 , Tamás Beke-Somfai4 , Szilvia Barkó3 , Edina Szabó-Meleg3 , and Mihály Kovács1,2
Pubblicato in: bioRxiv, 2025, ISSN 2692-8205
Editore: bioRxiv
DOI: 10.1101/2025.08.28.672810V1

DRMAAtic: dramatically improve your cluster potential

Autori: Del Conte, Alessio; Ghafouri, Hamidreza; Clementel, Damiano; Mičetić, Ivan; Piovesan, Damiano; Tosatto, Silvio C E; Monzon, Alexander Miguel
Pubblicato in: Bioinformatics Advances, 2024, ISSN 2635-0041
Editore: Oxford University Press
DOI: 10.1093/BIOADV/VBAF112

GeomeTRe: accurate calculation of geometrical descriptors of tandem repeat proteins

Autori: Osmanli, Zarifa; Ferrero, Elisa; Monzon, Alexander Miguel; Tosatto, Silvio C E; Piovesan, Damiano
Pubblicato in: Bioinformatics, 2025, ISSN 1367-4811
Editore: Oxford Academic
DOI: 10.1093/BIOINFORMATICS/BTAF395

Deep learning for intrinsically disordered proteins: From improved predictions to deciphering conformational ensembles

Autori: Gábor Erdős, Zsuzsanna Dosztányi
Pubblicato in: Current Opinion in Structural Biology, Numero 89, 2024, ISSN 0959-440X
Editore: Elsevier BV
DOI: 10.1016/j.sbi.2024.102950

Critical Assessment of Protein Intrinsic Disorder Round 3 ‐ Predicting Disorder in the Era of Protein Language Models

Autori: Mahta Mehdiabadi, Alessio Del Conte, Maria Victoria Nugnes, Maria Cristina Aspromonte, Silvio C. E. Tosatto, Damiano Piovesan
Pubblicato in: Proteins: Structure, Function, and Bioinformatics, 2025, ISSN 0887-3585
Editore: Wiley
DOI: 10.1002/PROT.70045