Bringing Intrinsically Disordered Proteins to Biomedical Applications

Información del proyecto

IDP2Biomed

Identificador del acuerdo de subvención: 101160233

DOI

10.3030/101160233

Fecha de la firma de la CE 9 Mayo 2024

Fecha de inicio 1 Octubre 2024

Fecha de finalización 30 Septiembre 2027

Financiado con arreglo a

• Widening participation and spreading excellence

Coste total

Sin datos

Aportación de la UE

€ 1 244 706,00

Coordinado por

EOTVOS LORAND TUDOMANYEGYETEM
Hungary

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Data Management Plan (1)

Data Management Plan

Websites, patent fillings, videos etc. (2)

Launch of the IDP2Biomed HUB
Launch of the IDP2Biomed website and links to social media, Communication toolkit

Launch of the IDP2Biomed website and links to social media, communication toolkit

Documents, reports (2)

Detailed Dissemination, Communication, Outreach and Exploitation Plan (DCOP) (Lead: ELTE)
Report on state-of-the art of characterizing conformational states of IDPs

Publicaciones

Peer reviewed articles (12)

AIUPred - Binding: energy embedding to identify disordered binding regions

Autores: Gábor Erdős, Norbert Deutsch, Zsuzsanna Dosztányi
Publicado en: Journal of Molecular Biology, 2025, ISSN 0022-2836
Editor: Elsevier BV
DOI: 10.1016/J.JMB.2025.169071

Towards a Unified Framework for Determining Conformational Ensembles of Disordered Proteins

Autores: Hamidreza Ghafouri, Pavel Kadeřávek, Ana M Melo, Maria Cristina Aspromonte, Pau Bernadó, Juan Cortes, Zsuzsanna Dosztányi, Gabor Erdos, Michael Feig, Giacomo Janson, Kresten Lindorff-Larsen, Frans A. A. Mulder, Peter Nagy, Richard Pestell, Damiano Piovesa
Publicado en: arXiv, 2025, ISSN 2331-8422
Editor: Cornell University
DOI: 10.48550/ARXIV.2504.03590

DisProt in 2026: enhancing intrinsically disordered proteins accessibility, deposition, and annotation

Autores: Maria Victoria Nugnes, Kamel Eddine Adel Bouhraoua, Mehdi Zoubiri, Rita Pancsa, Erzsébet Fichó, null null, Alexander M Monzon, Ana M Melo, Edoardo Salladini, Emanuela Leonardi, Federica Quaglia, Daniyal Nasiribavil, Hamidreza Ghafouri, Gobeill Julien, Emilie Pasche, Patrick Ruch, Paul Van Rijen, László Dobson, Marco Schiavina, Trinidad Cordero, Zsófia E Kálmán, Ximena Castro, Valentín Iglesias, István Reményi, Mahta Mehdiabadi, Gábor Erdős, Zsuzsanna Dosztányi, Peter Tompa, Damiano Piovesan, Silvio C E Tosatto, Maria Cristina Aspromonte
Publicado en: Nucleic Acids Research, Edición 54, 2026, ISSN 0305-1048
Editor: Oxford University Press (OUP)
DOI: 10.1093/NAR/GKAF1175

Selective engineering of condensation properties of single-stranded DNA binding (SSB) protein via its intrinsically disordered linker region

Autores: Péter Ecsédi; Dávid Érfalvy; Zoltán J Kovács; Viktoria Katran; János Pálinkás; Miklós Cervenak; Rita Pancsa; Gábor M Harami; László Smeller; Mihály Kovács
Publicado en: Nucleic Acids Research, 2025, ISSN 1362-4962
Editor: Oxford University Press
DOI: 10.1093/NAR/GKAF481

Fine‐tuned interactions between globular and disordered regions of single‐stranded <scp>DNA</scp> binding (<scp>SSB</scp>) protein are required for dynamic condensation under physiological conditions

Autores: Zoltán J. Kovács; Péter Ecsédi; Gábor M. Harami; János Pálinkás; Mina Botros; Lamiya Mahmudova; Viktoria Katran; Dávid Érfalvy; Miklós Cervenak; László Smeller; Mihály Kovács
Publicado en: Protein Science, 2025, ISSN 1613-6829
Editor: Wiley
DOI: 10.1002/PRO.70109

<scp>DR</scp> and <scp>SPIT</scp>: Statistical approaches for identifying transient structure in intrinsically disordered proteins via <scp>NMR</scp> chemical shifts

Autores: Dániel Kovács; Andrea Bodor
Publicado en: Protein Science, 2025, ISSN 1469-896X
Editor: Wiley-Blackwel
DOI: 10.1002/PRO.70250

MOBIDB in 2025: integrating ensemble properties and function annotations for intrinsically disordered proteins

Autores: Damiano Piovesan; Alessio Del Conte; Mahta Mehdiabadi; Maria Cristina Aspromonte; Matthias Blum; Giulio Tesei; Sören von Bülow; Kresten Lindorff-Larsen; Silvio C E Tosatto
Publicado en: Nucleic Acids Research, 2024, ISSN 1362-4962
Editor: Oxford University Press
DOI: 10.1093/NAR/GKAE969

Phase transition drives bacterial single-stranded DNA binding (SSB) protein mobilization during stress response and metabolic adaptation

Autores: Péter Ecsédi1 , Júlia Szittyai1 , János Pálinkás1,2, Bálint Jezsó1,2, Viktoria Katran1 , Zoltán J. Kovács1,2, Henriett Halász3 , Tasvilla Sonallya4 , Tünde Juhász4 , Tamás Beke-Somfai4 , Szilvia Barkó3 , Edina Szabó-Meleg3 , and Mihály Kovács1,2
Publicado en: bioRxiv, 2025, ISSN 2692-8205
Editor: bioRxiv
DOI: 10.1101/2025.08.28.672810V1

DRMAAtic: dramatically improve your cluster potential

Autores: Del Conte, Alessio; Ghafouri, Hamidreza; Clementel, Damiano; Mičetić, Ivan; Piovesan, Damiano; Tosatto, Silvio C E; Monzon, Alexander Miguel
Publicado en: Bioinformatics Advances, 2024, ISSN 2635-0041
Editor: Oxford University Press
DOI: 10.1093/BIOADV/VBAF112

GeomeTRe: accurate calculation of geometrical descriptors of tandem repeat proteins

Autores: Osmanli, Zarifa; Ferrero, Elisa; Monzon, Alexander Miguel; Tosatto, Silvio C E; Piovesan, Damiano
Publicado en: Bioinformatics, 2025, ISSN 1367-4811
Editor: Oxford Academic
DOI: 10.1093/BIOINFORMATICS/BTAF395

Deep learning for intrinsically disordered proteins: From improved predictions to deciphering conformational ensembles

Autores: Gábor Erdős, Zsuzsanna Dosztányi
Publicado en: Current Opinion in Structural Biology, Edición 89, 2024, ISSN 0959-440X
Editor: Elsevier BV
DOI: 10.1016/j.sbi.2024.102950

Critical Assessment of Protein Intrinsic Disorder Round 3 ‐ Predicting Disorder in the Era of Protein Language Models

Autores: Mahta Mehdiabadi, Alessio Del Conte, Maria Victoria Nugnes, Maria Cristina Aspromonte, Silvio C. E. Tosatto, Damiano Piovesan
Publicado en: Proteins: Structure, Function, and Bioinformatics, 2025, ISSN 0887-3585
Editor: Wiley
DOI: 10.1002/PROT.70045