Precision biomarker based on digital pathology and artificial intelligence to guide fast and cost-effective personalized treatment decision support for colorectal cancer patients

Informations projet

Histotype Px

N° de convention de subvention: 101161792

DOI

10.3030/101161792

Date de signature de la CE 27 Juin 2024

Date de début 1 Juin 2024

Date de fin 31 Mai 2026

Financé au titre de

• The European Innovation Council (EIC)

Coût total

€ 5 326 967,50

Contribution de l’UE

€ 2 499 999,99

Coordonné par

DOMORE DIAGNOSTICS AS
Norway

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (2)

Submitted publication of validation at an external hospital setting

Scientific article or abstract that is submitted for publication. The publication will be led by Stavanger University Hospital.1) the institution will gather and structure the data and will lead submission of the publication; 2) both parties will be involved in planning the projects and analyzing and interpreting the data that forms the basis of the publication; 3) DoMore Diagnostics will analyze slides and generate patient classifications for the publication.

Submitted publication on validation on Dutch cohort and as predictive biomarker

Scientific article led by UMC Utrecht with supportive evidence for guideline inclusion, commercialization, and clinical use.1) the institution will gather and structure the data and will lead submission of the publication; 2) both parties will be involved in planning the projects and analyzing and interpreting the data that forms the basis of the publication; 3) DoMore Diagnostics will analyze slides and generate patient classifications for the publication.

Publications

Peer reviewed articles (3)

Clinical validation of Histotype Px Colorectal in patients in a U.S. colon cancer cohort.

Auteurs: Vidya Arole, Sepp De Raedt, Jessica Maupin, Sandra Boutros, Anne M. Noonan, Giovanni Lujan, Eric David Miller
Publié dans: Journal of Clinical Oncology, Numéro 42, 2024, ISSN 0732-183X
Éditeur: American Society of Clinical Oncology (ASCO)
DOI: 10.1200/JCO.2024.42.16_SUPPL.3622

Pathology Visions 2024 Overview

Publié dans: Journal of Pathology Informatics, Numéro 16, 2025, ISSN 2153-3539
Éditeur: Elsevier BV
DOI: 10.1016/J.JPI.2025.100419

Complementary value of a digital pathology biomarker to post-surgery circulating tumor DNA in risk stratification of stage III colon cancer patients receiving adjuvant chemotherapy.

Auteurs: Ingrid Franken, Marie-Christine Bakker, Sjoerd G. Elias, Miangela M. Lacle, Nikolas Stathonikos, Carmen Rubio-Alarcon, Mark Sausen, Miriam Koopman, Gerrit A. Meijer, Geraldine R. Vink, Remond Fijneman, Sepp De Raedt, Karolina Cyll, Ole-Johan Skrede, Hanne Askautrud, Tarjei S. Hveem, Lao H. Saal, Torbjørn Furuseth, Andreas Kleppe, Jeanine Roodhart
Publié dans: Journal of Clinical Oncology, Numéro 43, 2025, ISSN 0732-183X
Éditeur: American Society of Clinical Oncology (ASCO)
DOI: 10.1200/JCO.2025.43.16_SUPPL.3604

Conference proceedings (2)

554P Novel clinical decision support (CDS) system optimizing adjuvant chemotherapy (ACT) for colorectal cancer (CRC) by integrating deep learning and circulating tumor DNA (ctDNA) molecular residual disease (MRD): GALAXY histotyping

Auteurs: Y. Nakamura, W. Kildal, T. Misumi, M. Pradhan, J. Watanabe, O-J. Skrede, D. Kotani, S.D. Raedt, H. Bando, J. Kalsnes, H. Taniguchi, K. Liestøl, I. Takemasa, T.S. Hveem, T. Kato, M. Novelli, E. Oki, D.J. Kerr, T. Yoshino, A. Kleppe
Publié dans: Annals of Oncology, Numéro 35, 2024, ISSN 0923-7534
Éditeur: Elsevier BV
DOI: 10.1016/J.ANNONC.2024.08.623

Histotype Px Colorectal as an AI biomarker to guide use of adjuvant therapy in patients with resected colon cancer

Auteurs: Arole, V., De Raedt, S., Maupin, J. Boutros, S., Handley, D., Noonan, A.M., Miller, E., Lujan, G.
Publié dans: Journal of Pathology informatics, Numéro 16, 2025
Éditeur: Elsevier
DOI: 10.1016/J.JPI.2025.100419

Droits de propriété intellectuelle

Patent (2)

HISTOLOGICAL IMAGE ANALYSIS

Numéro de demande/publication: 20 780593
Date: 2020-09-18
Demandeur(s): DOMORE DIAGNOSTICS AS

HISTOLOGICAL IMAGE ANALYSIS

Numéro de demande/publication: 18 800165
Date: 2018-11-09
Demandeur(s): DOMORE DIAGNOSTICS AS