Precision biomarker based on digital pathology and artificial intelligence to guide fast and cost-effective personalized treatment decision support for colorectal cancer patients

Información del proyecto

Histotype Px

Identificador del acuerdo de subvención: 101161792

DOI

10.3030/101161792

Fecha de la firma de la CE 27 Junio 2024

Fecha de inicio 1 Junio 2024

Fecha de finalización 31 Mayo 2026

Financiado con arreglo a

• The European Innovation Council (EIC)

Coste total

€ 5 326 967,50

Aportación de la UE

€ 2 499 999,99

Coordinado por

DOMORE DIAGNOSTICS AS
Norway

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (2)

Submitted publication of validation at an external hospital setting

Scientific article or abstract that is submitted for publication. The publication will be led by Stavanger University Hospital.1) the institution will gather and structure the data and will lead submission of the publication; 2) both parties will be involved in planning the projects and analyzing and interpreting the data that forms the basis of the publication; 3) DoMore Diagnostics will analyze slides and generate patient classifications for the publication.

Submitted publication on validation on Dutch cohort and as predictive biomarker

Scientific article led by UMC Utrecht with supportive evidence for guideline inclusion, commercialization, and clinical use.1) the institution will gather and structure the data and will lead submission of the publication; 2) both parties will be involved in planning the projects and analyzing and interpreting the data that forms the basis of the publication; 3) DoMore Diagnostics will analyze slides and generate patient classifications for the publication.

Publicaciones

Peer reviewed articles (3)

Clinical validation of Histotype Px Colorectal in patients in a U.S. colon cancer cohort.

Autores: Vidya Arole, Sepp De Raedt, Jessica Maupin, Sandra Boutros, Anne M. Noonan, Giovanni Lujan, Eric David Miller
Publicado en: Journal of Clinical Oncology, Edición 42, 2024, ISSN 0732-183X
Editor: American Society of Clinical Oncology (ASCO)
DOI: 10.1200/JCO.2024.42.16_SUPPL.3622

Pathology Visions 2024 Overview

Publicado en: Journal of Pathology Informatics, Edición 16, 2025, ISSN 2153-3539
Editor: Elsevier BV
DOI: 10.1016/J.JPI.2025.100419

Complementary value of a digital pathology biomarker to post-surgery circulating tumor DNA in risk stratification of stage III colon cancer patients receiving adjuvant chemotherapy.

Autores: Ingrid Franken, Marie-Christine Bakker, Sjoerd G. Elias, Miangela M. Lacle, Nikolas Stathonikos, Carmen Rubio-Alarcon, Mark Sausen, Miriam Koopman, Gerrit A. Meijer, Geraldine R. Vink, Remond Fijneman, Sepp De Raedt, Karolina Cyll, Ole-Johan Skrede, Hanne Askautrud, Tarjei S. Hveem, Lao H. Saal, Torbjørn Furuseth, Andreas Kleppe, Jeanine Roodhart
Publicado en: Journal of Clinical Oncology, Edición 43, 2025, ISSN 0732-183X
Editor: American Society of Clinical Oncology (ASCO)
DOI: 10.1200/JCO.2025.43.16_SUPPL.3604

Conference proceedings (2)

554P Novel clinical decision support (CDS) system optimizing adjuvant chemotherapy (ACT) for colorectal cancer (CRC) by integrating deep learning and circulating tumor DNA (ctDNA) molecular residual disease (MRD): GALAXY histotyping

Autores: Y. Nakamura, W. Kildal, T. Misumi, M. Pradhan, J. Watanabe, O-J. Skrede, D. Kotani, S.D. Raedt, H. Bando, J. Kalsnes, H. Taniguchi, K. Liestøl, I. Takemasa, T.S. Hveem, T. Kato, M. Novelli, E. Oki, D.J. Kerr, T. Yoshino, A. Kleppe
Publicado en: Annals of Oncology, Edición 35, 2024, ISSN 0923-7534
Editor: Elsevier BV
DOI: 10.1016/J.ANNONC.2024.08.623

Histotype Px Colorectal as an AI biomarker to guide use of adjuvant therapy in patients with resected colon cancer

Autores: Arole, V., De Raedt, S., Maupin, J. Boutros, S., Handley, D., Noonan, A.M., Miller, E., Lujan, G.
Publicado en: Journal of Pathology informatics, Edición 16, 2025
Editor: Elsevier
DOI: 10.1016/J.JPI.2025.100419

Derechos de propiedad intelectual

Patent (2)

HISTOLOGICAL IMAGE ANALYSIS

Número de solicitud/publicación: 20 780593
Fecha: 2020-09-18
Solicitante(s): DOMORE DIAGNOSTICS AS

HISTOLOGICAL IMAGE ANALYSIS

Número de solicitud/publicación: 18 800165
Fecha: 2018-11-09
Solicitante(s): DOMORE DIAGNOSTICS AS