Precision biomarker based on digital pathology and artificial intelligence to guide fast and cost-effective personalized treatment decision support for colorectal cancer patients

Project Information

Histotype Px

Grant agreement ID: 101161792

DOI

10.3030/101161792

Project closed

EC signature date 27 June 2024

Start date 1 June 2024

End date 31 May 2026

Funded under

• The European Innovation Council (EIC)

Total cost

€ 5 326 967,50

EU contribution

€ 2 499 999,99

Coordinated by

DOMORE DIAGNOSTICS AS
Norway

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (2)

Submitted publication of validation at an external hospital setting

Scientific article or abstract that is submitted for publication. The publication will be led by Stavanger University Hospital.1) the institution will gather and structure the data and will lead submission of the publication; 2) both parties will be involved in planning the projects and analyzing and interpreting the data that forms the basis of the publication; 3) DoMore Diagnostics will analyze slides and generate patient classifications for the publication.

Submitted publication on validation on Dutch cohort and as predictive biomarker

Scientific article led by UMC Utrecht with supportive evidence for guideline inclusion, commercialization, and clinical use.1) the institution will gather and structure the data and will lead submission of the publication; 2) both parties will be involved in planning the projects and analyzing and interpreting the data that forms the basis of the publication; 3) DoMore Diagnostics will analyze slides and generate patient classifications for the publication.

Publications

Peer reviewed articles (2)

Clinical validation of Histotype Px Colorectal in patients in a U.S. colon cancer cohort.

Author(s): Vidya Arole, Sepp De Raedt, Jessica Maupin, Sandra Boutros, Anne M. Noonan, Giovanni Lujan, Eric David Miller
Published in: Journal of Clinical Oncology, Issue 42, 2024, ISSN 0732-183X
Publisher: American Society of Clinical Oncology (ASCO)
DOI: 10.1200/JCO.2024.42.16_SUPPL.3622

Complementary value of a digital pathology biomarker to post-surgery circulating tumor DNA in risk stratification of stage III colon cancer patients receiving adjuvant chemotherapy.

Author(s): Ingrid Franken, Marie-Christine Bakker, Sjoerd G. Elias, Miangela M. Lacle, Nikolas Stathonikos, Carmen Rubio-Alarcon, Mark Sausen, Miriam Koopman, Gerrit A. Meijer, Geraldine R. Vink, Remond Fijneman, Sepp De Raedt, Karolina Cyll, Ole-Johan Skrede, Hanne Askautrud, Tarjei S. Hveem, Lao H. Saal, Torbjørn Furuseth, Andreas Kleppe, Jeanine Roodhart
Published in: Journal of Clinical Oncology, Issue 43, 2025, ISSN 0732-183X
Publisher: American Society of Clinical Oncology (ASCO)
DOI: 10.1200/JCO.2025.43.16_SUPPL.3604

Conference proceedings (4)

726O Prognostic value of the combined analysis of pathologists and artificial intelligence (CAPAI) in high-risk stage II-III colon cancer treated without chemotherapy: Interim report from a nationwide validation

Author(s): M-C.E. Bakker, I.A. Franken, M.M. Laclé, K. Cyll, N. Stathonikos, S.D. Raedt, O-J. Skrede, H.A. Askautrud, T.S. Hveem, J. Kalsnes, M. Koopman, L.H. Saal, A.B. Storsve, T. Furuseth, S.G. Elias, A. Kleppe, J. Roodhart
Published in: Annals of Oncology, Issue 36, 2026, ISSN 0923-7534
Publisher: Elsevier BV
DOI: 10.1016/J.ANNONC.2025.08.1301

Real-world utility of Histotype Px colorectal as a prognostic and potentially predictive biomarker.

Author(s): Vidya Arole, Sepp De Raedt, Karen Meyers, Manohar Pradhan, Jessica Maupin, Joakim Kalsnes, Sandra Boutros, Ole-Johan Skrede, Anne M. Noonan, Hanne Askautrud, Tarjei S. Hveem, Lao H. Saal, Andreas Storsve, Torbjørn Furuseth, Giovanni Lujan, Andreas Kleppe, Eric David Miller
Published in: Journal of Clinical Oncology, Issue 44, 2026, ISSN 0732-183X
Publisher: American Society of Clinical Oncology (ASCO)
DOI: 10.1200/JCO.2026.44.2_SUPPL.215

554P Novel clinical decision support (CDS) system optimizing adjuvant chemotherapy (ACT) for colorectal cancer (CRC) by integrating deep learning and circulating tumor DNA (ctDNA) molecular residual disease (MRD): GALAXY histotyping

Author(s): Y. Nakamura, W. Kildal, T. Misumi, M. Pradhan, J. Watanabe, O-J. Skrede, D. Kotani, S.D. Raedt, H. Bando, J. Kalsnes, H. Taniguchi, K. Liestøl, I. Takemasa, T.S. Hveem, T. Kato, M. Novelli, E. Oki, D.J. Kerr, T. Yoshino, A. Kleppe
Published in: Annals of Oncology, Issue 35, 2024, ISSN 0923-7534
Publisher: Elsevier BV
DOI: 10.1016/J.ANNONC.2024.08.623

Histotype Px Colorectal as an AI biomarker to guide use of adjuvant therapy in patients with resected colon cancer

Author(s): Arole, V., De Raedt, S., Maupin, J. Boutros, S., Handley, D., Noonan, A.M., Miller, E., Lujan, G.
Published in: Journal of Pathology informatics, Issue 16, 2025
Publisher: Elsevier
DOI: 10.1016/J.JPI.2025.100419

Intellectual Property Rights

Patent (2)

HISTOLOGICAL IMAGE ANALYSIS

Application/Publication number: 20 780593
Date: 2020-09-18
Applicant(s): DOMORE DIAGNOSTICS AS

HISTOLOGICAL IMAGE ANALYSIS

Application/Publication number: 18 800165
Date: 2018-11-09
Applicant(s): DOMORE DIAGNOSTICS AS