Precision biomarker based on digital pathology and artificial intelligence to guide fast and cost-effective personalized treatment decision support for colorectal cancer patients

Informazioni relative al progetto

Histotype Px

ID dell’accordo di sovvenzione: 101161792

DOI

10.3030/101161792

Data della firma CE 27 Giugno 2024

Data di avvio 1 Giugno 2024

Data di completamento 31 Maggio 2026

Finanziato da

• The European Innovation Council (EIC)

Costo totale

€ 5 326 967,50

Contributo UE

€ 2 499 999,99

Coordinato da

DOMORE DIAGNOSTICS AS
Norway

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (2)

Submitted publication of validation at an external hospital setting

Scientific article or abstract that is submitted for publication. The publication will be led by Stavanger University Hospital.1) the institution will gather and structure the data and will lead submission of the publication; 2) both parties will be involved in planning the projects and analyzing and interpreting the data that forms the basis of the publication; 3) DoMore Diagnostics will analyze slides and generate patient classifications for the publication.

Submitted publication on validation on Dutch cohort and as predictive biomarker

Scientific article led by UMC Utrecht with supportive evidence for guideline inclusion, commercialization, and clinical use.1) the institution will gather and structure the data and will lead submission of the publication; 2) both parties will be involved in planning the projects and analyzing and interpreting the data that forms the basis of the publication; 3) DoMore Diagnostics will analyze slides and generate patient classifications for the publication.

Pubblicazioni

Peer reviewed articles (3)

Clinical validation of Histotype Px Colorectal in patients in a U.S. colon cancer cohort.

Autori: Vidya Arole, Sepp De Raedt, Jessica Maupin, Sandra Boutros, Anne M. Noonan, Giovanni Lujan, Eric David Miller
Pubblicato in: Journal of Clinical Oncology, Numero 42, 2024, ISSN 0732-183X
Editore: American Society of Clinical Oncology (ASCO)
DOI: 10.1200/JCO.2024.42.16_SUPPL.3622

Pathology Visions 2024 Overview

Pubblicato in: Journal of Pathology Informatics, Numero 16, 2025, ISSN 2153-3539
Editore: Elsevier BV
DOI: 10.1016/J.JPI.2025.100419

Complementary value of a digital pathology biomarker to post-surgery circulating tumor DNA in risk stratification of stage III colon cancer patients receiving adjuvant chemotherapy.

Autori: Ingrid Franken, Marie-Christine Bakker, Sjoerd G. Elias, Miangela M. Lacle, Nikolas Stathonikos, Carmen Rubio-Alarcon, Mark Sausen, Miriam Koopman, Gerrit A. Meijer, Geraldine R. Vink, Remond Fijneman, Sepp De Raedt, Karolina Cyll, Ole-Johan Skrede, Hanne Askautrud, Tarjei S. Hveem, Lao H. Saal, Torbjørn Furuseth, Andreas Kleppe, Jeanine Roodhart
Pubblicato in: Journal of Clinical Oncology, Numero 43, 2025, ISSN 0732-183X
Editore: American Society of Clinical Oncology (ASCO)
DOI: 10.1200/JCO.2025.43.16_SUPPL.3604

Conference proceedings (2)

554P Novel clinical decision support (CDS) system optimizing adjuvant chemotherapy (ACT) for colorectal cancer (CRC) by integrating deep learning and circulating tumor DNA (ctDNA) molecular residual disease (MRD): GALAXY histotyping

Autori: Y. Nakamura, W. Kildal, T. Misumi, M. Pradhan, J. Watanabe, O-J. Skrede, D. Kotani, S.D. Raedt, H. Bando, J. Kalsnes, H. Taniguchi, K. Liestøl, I. Takemasa, T.S. Hveem, T. Kato, M. Novelli, E. Oki, D.J. Kerr, T. Yoshino, A. Kleppe
Pubblicato in: Annals of Oncology, Numero 35, 2024, ISSN 0923-7534
Editore: Elsevier BV
DOI: 10.1016/J.ANNONC.2024.08.623

Histotype Px Colorectal as an AI biomarker to guide use of adjuvant therapy in patients with resected colon cancer

Autori: Arole, V., De Raedt, S., Maupin, J. Boutros, S., Handley, D., Noonan, A.M., Miller, E., Lujan, G.
Pubblicato in: Journal of Pathology informatics, Numero 16, 2025
Editore: Elsevier
DOI: 10.1016/J.JPI.2025.100419

Diritti di proprietà intellettuale

Patent (2)

HISTOLOGICAL IMAGE ANALYSIS

Numero candidatura/pubblicazione: 20 780593
Data: 2020-09-18
Candidato/i: DOMORE DIAGNOSTICS AS

HISTOLOGICAL IMAGE ANALYSIS

Numero candidatura/pubblicazione: 18 800165
Data: 2018-11-09
Candidato/i: DOMORE DIAGNOSTICS AS