Reducing Non-Human Primates in Non-Clinical Safety Assessment: The European Initiative on Minipig and Micropig Models

Informazioni relative al progetto

NHPig

ID dell’accordo di sovvenzione: 101165643

DOI

10.3030/101165643

Data della firma CE 12 Novembre 2024

Data di avvio 1 Ottobre 2024

Data di completamento 30 Settembre 2029

Finanziato da

• Health

Costo totale

€ 17 522 696,50

Contributo UE

€ 8 499 555,50

Coordinato da

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (5)

Framework for verification, validation, and qualification of minipig digital measurements

This deliverable will detail the process and results of the framework developed to verify, validate and quality the remote monitoring system

Outreach tools

Key communication channels set up

NHPigDB

Report on Task 5.1 (development of extended SEND format for NHPig and status of NHPig database development)

NHPig SOP

Report on Task 3.1 (optimized SOPs, integration of historical protocols from public and private partners)

PDECA 1

A Plan for Dissemination, Exploitation and Communication Activities created

Pubblicazioni

Peer reviewed articles (7)

Clinical application of single‐cell RNA sequencing in disease and therapy

Autori: Aisha Shigna Nadukkandy, Sowmiya Kalaiselvan, Lin Lin, Yonglun Luo
Pubblicato in: Clinical and Translational Medicine, Numero 15, 2025, ISSN 2001-1326
Editore: Wiley
DOI: 10.1002/CTM2.70512

Corrigendum to “Considerations for use of humanized IgG1/4 Göttingen minipigs in safety assessment of antibody-based therapeutics” [Regul. Toxicol. Pharmacol., (161) (2025) 105855]

Autori: Anna Engstrom, Tine Dahlbaek Hannibal, Jerome Egli, Beatrice Gauthier, Mikkel Lykke Krarup, Daniela Gallo, Andres Eskjær Jensen, Steven Van Cruchten, Steven Bulera, Miranda Cornet, Sabine Elisabeth Hammer, David Henry, Bjoern Jacobsen, John Kendrick, Lars Siim Madsen, Sofiene Mhedhbi, Steven Oag, Henrik Duelund Pedersen, Manuela Teti, Pramila Singh
Pubblicato in: Regulatory Toxicology and Pharmacology, Numero 162, 2025, ISSN 0273-2300
Editore: Elsevier BV
DOI: 10.1016/J.YRTPH.2025.105908

Considerations for use of humanized IgG1/4 Göttingen minipigs in safety assessment of antibody-based therapeutics

Autori: Anna Engstrom, Tine Dahlbaek Hannibal, Jerome Egli, Beatrice Gauthier, Mikkel Lykke Krarup, Daniela Gallo, Andres Eskjær Jensen, Steven Van Cruchten, Steven Bulera, Miranda Cornet, Sabine Elisabeth Hammer, David Henry, Bjoern Jacobsen, John Kendrick, Lars Siim Madsen, Sofiene Mhedhbi, Steven Oag, Henrik Duelund Pedersen, Manuela Teti, Pramila Singh
Pubblicato in: Regulatory Toxicology and Pharmacology, Numero 161, 2025, ISSN 0273-2300
Editore: Elsevier BV
DOI: 10.1016/J.YRTPH.2025.105855

Advanced delivery systems for gene editing: A comprehensive review from the GenE-HumDi COST Action Working Group

Autori: Alessia Cavazza, Francisco J. Molina-Estévez, Álvaro Plaza Reyes, Victor Ronco, Asma Naseem, Špela Malenšek, Peter Pečan, Annalisa Santini, Paula Heredia, Araceli Aguilar-González, Houria Boulaiz, Qianqian Ni, Marina Cortijo-Gutierrez, Kristina Pavlovic, Inmaculada Herrera, Berta de la Cerda, Emilio M. Garcia-Tenorio, Eva Richard, Sergio Granados-Principal, Arístides López-Márquez, Mariana Köber, Marijana Stojanovic, Melita Vidaković, Irene Santos-Garcia, Lorea Blázquez, Emily Haughton, Dongnan Yan, Rosario María Sánchez-Martín, Loubna Mazini, Gloria Gonzalez Aseguinolaza, Annarita Miccio, Paula Rio, Lourdes R. Desviat, Manuel A.F.V. Gonçalves, Ling Peng, Cecilia Jiménez-Mallebrera, Francisco Martin Molina, Dhanu Gupta, Duško Lainšček, Yonglun Luo, Karim Benabdellah
Pubblicato in: Molecular Therapy Nucleic Acids, Numero 36, 2025, ISSN 2162-2531
Editore: Elsevier BV
DOI: 10.1016/J.OMTN.2025.102457

Unraveling porcine dendritic-cell diversity: welcome tDC and DC3

Autori: Ambre Baillou, Gaël Auray, Francisco Brito, Marius Botos, Alizée Huber, Artur Summerfield, Stephanie C. Talker
Pubblicato in: Frontiers in Immunology, Numero 16, 2025, ISSN 1664-3224
Editore: Frontiers Media SA
DOI: 10.3389/FIMMU.2025.1639553

Protocol for in vivo assessment of glucose control and insulin secretion and sensitivity in the pig

Autori: Yasmin Eckstein, Barbara Kessler, Arne Hinrichs, Istvan Novak, Anne von Thaden, Timo Lorenzen, Birgit Rathkolb, Armin Scholz, Andreas Blutke, Sietse-Jan Koopmans, Martin Hrabĕ de Angelis, Berit Østergaard Christoffersen, Eckhard Wolf, Simone Renner
Pubblicato in: STAR Protocols, Numero 6, 2025, ISSN 2666-1667
Editore: Elsevier BV
DOI: 10.1016/J.XPRO.2025.103774

Landscape of A-I RNA editing in mouse, pig, macaque, and human brains

Autori: Conghui Li, Wei Lv, Zhiwei He, Xiaoguang Pan, Yuchen Zeng, Jan Mulder, Evelina Sjöstedt, Zhiwei Huang, Wei Liu, Liangzhi Xu, Eli Eisenberg, Lin Lin, Jacob B Hansen, Jinrong Huang, Yonglun Luo
Pubblicato in: Nucleic Acids Research, Numero 53, 2025, ISSN 0305-1048
Editore: Oxford University Press (OUP)
DOI: 10.1093/NAR/GKAF534