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Innovative approaches to implantation research in health and disease

Ziel

Implantation of the embryo in a receptive uterus is critical for mammalian reproduction, yet remains poorly understood. This challenge is particularly significant in human health, as up to two-thirds of human pregnancies are lost due implantation failure. In the agricultural sector, particularly in sustainable milk and meat production, understanding and improving embryo implantation is equally crucial. High peri-implantation mortality rates in livestock lead to lower efficiency, profitability, and environmental sustainability. Much remains unknown about the molecular pathways and regulatory mechanisms of embryo-endometrial interactions in humans and livestock species. For ethical and practical reasons, implantation cannot be adequately studied in vivo in human, and it remains challenging in most animal models.
IMPLANTEU is an international community of researchers whose objectives are:
1) To develop a molecular blueprint of human implantation in health and disease;
2) To improve implantation fitness for food production mammals and
3) To develop an advanced toolkit for implantation research.
IMPLANTEU provides multi-species, multi-sector and multi-model molecular and system implantation research, integrating complementary expertise in reproductive and stem cells biology, medicine, physiology, ethics and law, and cutting-edge technologies such as stem cell-based embryo models, organoids, machine learning, and organ-on-chip.
IMPLANTEU will train 13 doctoral candidates through research, innovation, secondments in academic and industrial environments, horizontal and focused courses, and interactions with stakeholders. The findings generated through IMPLANTEU will contribute to the profound understanding of the embryonic and endometrial contribution to reproductive success, innovations in infertility treatment, animal production efficiency and sustainability, tissue bioengineering, pathogen-host interaction, reproductive toxicology, and stem cell biology.

Wissenschaftliches Gebiet (EuroSciVoc)

Schlüsselbegriffe

Programm/Programme

Thema/Themen

Finanzierungsplan

HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral Networks

Alle im Rahmen dieses Finanzierungsinstruments finanzierten Projekte anzeigen

Aufforderung zur Vorschlagseinreichung

(öffnet in neuem Fenster) HORIZON-MSCA-2023-DN-01

Alle im Rahmen dieser Aufforderung zur Einreichung von Vorschlägen finanzierten Projekte anzeigen

Koordinator

EUVITRO SLU
Netto-EU-Beitrag
€ 503 942,40
Adresse
CARRER DE BALMES 236
08006 BARCELONA
Spanien
KMU
Ja
Region
Este Cataluña Barcelona
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Links
Gesamtkosten
Keine Daten

Beteiligte (10)

Partner (4)