Developing and implementing VIrtual Control groups To reducE animal use in toxicology Research

Informations projet

VICT3R

N° de convention de subvention: 101172693

DOI

10.3030/101172693

Date de signature de la CE 26 Juillet 2024

Date de début 1 Septembre 2024

Date de fin 29 Février 2028

Financé au titre de

• Health

Coût total

€ 26 995 885,75

Contribution de l’UE

€ 13 524 750,00

Coordonné par

UNIVERSIDAD POMPEU FABRA
Spain

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (7)

Workshop with SEND experts

Summary of the outcomes of the workshop and proposed new terminology

Study designs overview

A report providing an overview on study designs across industries

First plan for dissemination and communication activities

Initial report on the communication strategy of the project, including the development of the initial tools

Identification of key covariates

Main covariates driving the variability of the endpoints measured in animals

Report on the data requirements and quality criteria

Definition of mandatory and optional fields in the VICOG DB

Computer system validation

Report on the CSV activities carried out for the software tool listed in D9.1

Academic landscape of animal-based studies

A report providing an overview on types and frequency of animal-based study designs in academia

Data Management Plan (1)

Initial Data Management Plan (DMP)

First report to gather the relevant aspects of making the data FAIR

Publications

Peer reviewed articles (10)

Mapping out strategies to further develop human-relevant, new approach methodology (NAM)-based developmental neurotoxicity (DNT) testing

Auteurs: Eike, Cöllen; Kristina, Bartmann; Jonathan, Blum; Kelly, Carstens; Ivana, Celardo; Nivedita, Chatterjee; Marco, Corvaro; Nadine, Dreser; Ellen, Fritsche; Thomas, Hartung; Helena T, Hogberg; Thomas, K
Publié dans: ALTEX, 2025, ISSN 1868-596X
Éditeur: ALTEX Edition
DOI: 10.14573/ALTEX.2501091

The need for epigenotoxicity testing.

Auteurs: Hartung T, Smirnova L, Platz S, Amelio I, Leist M.
Publié dans: ALTEX, Numéro 42, 2025, ISSN 1868-596X
Éditeur: ALtex Edition
DOI: 10.14573/ALTEX.2509281

Transitional initiatives for advancing the phasing out of the use of animals for drug and chemical safety testing: The IHI VICT3R project for reducing the use of animals by implementing virtual control groups

Auteurs: Ferran Sanz, Julia Matyjasiak, Javier Orihuel, Colleen M. Pike, Inari Soininen, Frank Bringezu, Olga Valverde, Mathieu Vinken, Janette Turner, Thomas Steger-Hartmann
Publié dans: NAM Journal, 2025, ISSN 3050-6204
Éditeur: Elsevier BV
DOI: 10.1016/J.NAMJNL.2025.100065

Challenges and opportunities for validation of AI-based new approach methods.

Auteurs: Hartung T, Kleinstreuer N.
Publié dans: ALTEX, Numéro 42, 2025, ISSN 1868-596X
Éditeur: ALTEX Edition
DOI: 10.14573/ALTEX.2412291

The validation of regulatory test methods - Conceptual, ethical, and philosophical foundations.

Auteurs: Hartung T.
Publié dans: ALTEX, Numéro 41, 2024, ISSN 1868-596X
Éditeur: Altex Edition
DOI: 10.14573/ALTEX.2409271

Virtual control groups in non-clinical toxicology – A replicability challenge.

Auteurs: Steger-Hartmann T, Duchateau-Nguyen G, Bringezu F, Onidi M, Stirn M.
Publié dans: ALTEX, 2025, ISSN 1868-8551
Éditeur: ALTEX
DOI: 10.14573/ALTEX.2503061

Integrative Data Science in Drug Safety Research: Experiences, Challenges, and Perspectives

Auteurs: Ferran Sanz
Publié dans: Annual Review of Biomedical Data Science, Numéro 8, 2025, ISSN 2574-3414
Éditeur: Annual Reviews
DOI: 10.1146/ANNUREV-BIODATASCI-103123-095506

The long way from raw data to NAM-based information: Overview on data layers and processing steps

Auteurs: Blum J, Brüll M, Hengstler JG, Dietrich DR, Gruber AJ, Dipalo M, Kraushaar U, Mangas I, Terron A, Fritsche E, Marx-Stoelting P, Hardy B, Schepky A, Escher S, Hartung T, Landsiedel R, Odermatt A, Sach
Publié dans: ALTEX, Numéro 42, 2025, ISSN 1868-596X
Éditeur: ALTEX Edition
DOI: 10.14573/ALTEX.2412171

Leveraging biomarkers and translational medicine for preclinical safety - Lessons for advancing the validation of alternatives to animal testing

Auteurs: Hartung T, King NMP, Kleinstreuer N, Leist M, Tagle DA
Publié dans: ALTEX, 2024, ISSN 1868-596X
Éditeur: ALTEX Edition
DOI: 10.14573/ALTEX.2410011

IHI VICT3R: Developing and Implementing Virtual Control Groups to Reduce Animal Use in Toxicology Research

Auteurs: Thomas Steger-Hartmann, Ferran Sanz, Frank Bringezu, Inari Soininen
Publié dans: Toxicologic Pathology, 2025, ISSN 0192-6233
Éditeur: SAGE Publications
DOI: 10.1177/01926233241303906