Developing and implementing VIrtual Control groups To reducE animal use in toxicology Research

Projektinformationen

VICT3R

ID Finanzhilfevereinbarung: 101172693

DOI

10.3030/101172693

EK-Unterschriftsdatum 26 Juli 2024

Startdatum 1 September 2024

Enddatum 29 Februar 2028

Finanziert unter

• Health

Gesamtkosten

€ 26 995 885,75

EU-Beitrag

€ 13 524 750,00

Koordiniert durch

UNIVERSIDAD POMPEU FABRA
Spain

CORDIS bietet Links zu öffentlichen Ergebnissen und Veröffentlichungen von HORIZONT-Projekten.

Links zu Ergebnissen und Veröffentlichungen von RP7-Projekten sowie Links zu einigen Typen spezifischer Ergebnisse wie Datensätzen und Software werden dynamisch von OpenAIRE abgerufen.

Leistungen

Documents, reports (10)

Regulatory interactions (I)

Mid-term report on regulatory interactions

Midterm plan and report for dissemination and communication activities

Intermediate report on communication activities developed within the project

Workshop with SEND experts

Summary of the outcomes of the workshop and proposed new terminology

Study designs overview

A report providing an overview on study designs across industries

Report on data integrity

Description of measures and procedures to maintain the quality of the data

First plan for dissemination and communication activities

Initial report on the communication strategy of the project, including the development of the initial tools

Identification of key covariates

Main covariates driving the variability of the endpoints measured in animals

Report on the data requirements and quality criteria

Definition of mandatory and optional fields in the VICOG DB

Computer system validation

Report on the CSV activities carried out for the software tool listed in D9.1

Academic landscape of animal-based studies

A report providing an overview on types and frequency of animal-based study designs in academia

Data Management Plan (2)

Updated DMP
Initial Data Management Plan (DMP)

First report to gather the relevant aspects of making the data FAIR

Other (1)

Visualisation tools for VICT3R DB

Interactive tools to enable explorations and visualisations of the VICT3R DB

Demonstrators, pilots, prototypes (2)

Demonstrator on synthetic VCGs generation using AI

AI models for synthetic VCG generation, outlining technical specifications and validation results

Demonstrator on AI for data gap mitigation

Demonstration of the AI models designed to overcome data scarcity, including their functionalities and effectiveness in addressing missing data

Veröffentlichungen

Peer reviewed articles (11)

Mapping out strategies to further develop human-relevant, new approach methodology (NAM)-based developmental neurotoxicity (DNT) testing

Autoren: Eike, Cöllen; Kristina, Bartmann; Jonathan, Blum; Kelly, Carstens; Ivana, Celardo; Nivedita, Chatterjee; Marco, Corvaro; Nadine, Dreser; Ellen, Fritsche; Thomas, Hartung; Helena T, Hogberg; Thomas, K
Veröffentlicht in: ALTEX, 2025, ISSN 1868-596X
Herausgeber: ALTEX Edition
DOI: 10.14573/ALTEX.2501091

The need for epigenotoxicity testing.

Autoren: Hartung T, Smirnova L, Platz S, Amelio I, Leist M.
Veröffentlicht in: ALTEX, Ausgabe 42, 2025, ISSN 1868-596X
Herausgeber: ALtex Edition
DOI: 10.14573/ALTEX.2509281

Transitional initiatives for advancing the phasing out of the use of animals for drug and chemical safety testing: The IHI VICT3R project for reducing the use of animals by implementing virtual control groups

Autoren: Ferran Sanz, Julia Matyjasiak, Javier Orihuel, Colleen M. Pike, Inari Soininen, Frank Bringezu, Olga Valverde, Mathieu Vinken, Janette Turner, Thomas Steger-Hartmann
Veröffentlicht in: NAM Journal, 2025, ISSN 3050-6204
Herausgeber: Elsevier BV
DOI: 10.1016/J.NAMJNL.2025.100065

Challenges and opportunities for validation of AI-based new approach methods.

Autoren: Hartung T, Kleinstreuer N.
Veröffentlicht in: ALTEX, Ausgabe 42, 2025, ISSN 1868-596X
Herausgeber: ALTEX Edition
DOI: 10.14573/ALTEX.2412291

The validation of regulatory test methods - Conceptual, ethical, and philosophical foundations.

Autoren: Hartung T.
Veröffentlicht in: ALTEX, Ausgabe 41, 2024, ISSN 1868-596X
Herausgeber: Altex Edition
DOI: 10.14573/ALTEX.2409271

Virtual control groups in non-clinical toxicology – A replicability challenge.

Autoren: Steger-Hartmann T, Duchateau-Nguyen G, Bringezu F, Onidi M, Stirn M.
Veröffentlicht in: ALTEX, 2025, ISSN 1868-8551
Herausgeber: ALTEX
DOI: 10.14573/ALTEX.2503061

Integrative Data Science in Drug Safety Research: Experiences, Challenges, and Perspectives

Autoren: Ferran Sanz
Veröffentlicht in: Annual Review of Biomedical Data Science, Ausgabe 8, 2025, ISSN 2574-3414
Herausgeber: Annual Reviews
DOI: 10.1146/ANNUREV-BIODATASCI-103123-095506

The long way from raw data to NAM-based information: Overview on data layers and processing steps

Autoren: Blum J, Brüll M, Hengstler JG, Dietrich DR, Gruber AJ, Dipalo M, Kraushaar U, Mangas I, Terron A, Fritsche E, Marx-Stoelting P, Hardy B, Schepky A, Escher S, Hartung T, Landsiedel R, Odermatt A, Sach
Veröffentlicht in: ALTEX, Ausgabe 42, 2025, ISSN 1868-596X
Herausgeber: ALTEX Edition
DOI: 10.14573/ALTEX.2412171

Leveraging biomarkers and translational medicine for preclinical safety - Lessons for advancing the validation of alternatives to animal testing

Autoren: Hartung T, King NMP, Kleinstreuer N, Leist M, Tagle DA
Veröffentlicht in: ALTEX, 2024, ISSN 1868-596X
Herausgeber: ALTEX Edition
DOI: 10.14573/ALTEX.2410011

IHI VICT3R: Developing and Implementing Virtual Control Groups to Reduce Animal Use in Toxicology Research

Autoren: Thomas Steger-Hartmann, Ferran Sanz, Frank Bringezu, Inari Soininen
Veröffentlicht in: Toxicologic Pathology, 2025, ISSN 0192-6233
Herausgeber: SAGE Publications
DOI: 10.1177/01926233241303906

AI snake oil? A risk/benefit analysis for toxicology

Autoren: Thomas Hartung, Mohan Rao, Mamta Behl, Alexandra Maertens
Veröffentlicht in: Frontiers in Artificial Intelligence, Ausgabe 9, 2026, ISSN 2624-8212
Herausgeber: Frontiers Media SA
DOI: 10.3389/FRAI.2026.1779276