Developing and implementing VIrtual Control groups To reducE animal use in toxicology Research

Información del proyecto

VICT3R

Identificador del acuerdo de subvención: 101172693

DOI

10.3030/101172693

Fecha de la firma de la CE 26 Julio 2024

Fecha de inicio 1 Septiembre 2024

Fecha de finalización 29 Febrero 2028

Financiado con arreglo a

• Health

Coste total

€ 26 995 885,75

Aportación de la UE

€ 13 524 750,00

Coordinado por

UNIVERSIDAD POMPEU FABRA
Spain

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (10)

Regulatory interactions (I)

Mid-term report on regulatory interactions

Midterm plan and report for dissemination and communication activities

Intermediate report on communication activities developed within the project

Workshop with SEND experts

Summary of the outcomes of the workshop and proposed new terminology

Study designs overview

A report providing an overview on study designs across industries

Report on data integrity

Description of measures and procedures to maintain the quality of the data

First plan for dissemination and communication activities

Initial report on the communication strategy of the project, including the development of the initial tools

Identification of key covariates

Main covariates driving the variability of the endpoints measured in animals

Report on the data requirements and quality criteria

Definition of mandatory and optional fields in the VICOG DB

Computer system validation

Report on the CSV activities carried out for the software tool listed in D9.1

Academic landscape of animal-based studies

A report providing an overview on types and frequency of animal-based study designs in academia

Data Management Plan (2)

Updated DMP
Initial Data Management Plan (DMP)

First report to gather the relevant aspects of making the data FAIR

Other (1)

Visualisation tools for VICT3R DB

Interactive tools to enable explorations and visualisations of the VICT3R DB

Demonstrators, pilots, prototypes (2)

Demonstrator on synthetic VCGs generation using AI

AI models for synthetic VCG generation, outlining technical specifications and validation results

Demonstrator on AI for data gap mitigation

Demonstration of the AI models designed to overcome data scarcity, including their functionalities and effectiveness in addressing missing data

Publicaciones

Peer reviewed articles (11)

Mapping out strategies to further develop human-relevant, new approach methodology (NAM)-based developmental neurotoxicity (DNT) testing

Autores: Eike, Cöllen; Kristina, Bartmann; Jonathan, Blum; Kelly, Carstens; Ivana, Celardo; Nivedita, Chatterjee; Marco, Corvaro; Nadine, Dreser; Ellen, Fritsche; Thomas, Hartung; Helena T, Hogberg; Thomas, K
Publicado en: ALTEX, 2025, ISSN 1868-596X
Editor: ALTEX Edition
DOI: 10.14573/ALTEX.2501091

The need for epigenotoxicity testing.

Autores: Hartung T, Smirnova L, Platz S, Amelio I, Leist M.
Publicado en: ALTEX, Edición 42, 2025, ISSN 1868-596X
Editor: ALtex Edition
DOI: 10.14573/ALTEX.2509281

Transitional initiatives for advancing the phasing out of the use of animals for drug and chemical safety testing: The IHI VICT3R project for reducing the use of animals by implementing virtual control groups

Autores: Ferran Sanz, Julia Matyjasiak, Javier Orihuel, Colleen M. Pike, Inari Soininen, Frank Bringezu, Olga Valverde, Mathieu Vinken, Janette Turner, Thomas Steger-Hartmann
Publicado en: NAM Journal, 2025, ISSN 3050-6204
Editor: Elsevier BV
DOI: 10.1016/J.NAMJNL.2025.100065

Challenges and opportunities for validation of AI-based new approach methods.

Autores: Hartung T, Kleinstreuer N.
Publicado en: ALTEX, Edición 42, 2025, ISSN 1868-596X
Editor: ALTEX Edition
DOI: 10.14573/ALTEX.2412291

The validation of regulatory test methods - Conceptual, ethical, and philosophical foundations.

Autores: Hartung T.
Publicado en: ALTEX, Edición 41, 2024, ISSN 1868-596X
Editor: Altex Edition
DOI: 10.14573/ALTEX.2409271

Virtual control groups in non-clinical toxicology – A replicability challenge.

Autores: Steger-Hartmann T, Duchateau-Nguyen G, Bringezu F, Onidi M, Stirn M.
Publicado en: ALTEX, 2025, ISSN 1868-8551
Editor: ALTEX
DOI: 10.14573/ALTEX.2503061

Integrative Data Science in Drug Safety Research: Experiences, Challenges, and Perspectives

Autores: Ferran Sanz
Publicado en: Annual Review of Biomedical Data Science, Edición 8, 2025, ISSN 2574-3414
Editor: Annual Reviews
DOI: 10.1146/ANNUREV-BIODATASCI-103123-095506

The long way from raw data to NAM-based information: Overview on data layers and processing steps

Autores: Blum J, Brüll M, Hengstler JG, Dietrich DR, Gruber AJ, Dipalo M, Kraushaar U, Mangas I, Terron A, Fritsche E, Marx-Stoelting P, Hardy B, Schepky A, Escher S, Hartung T, Landsiedel R, Odermatt A, Sach
Publicado en: ALTEX, Edición 42, 2025, ISSN 1868-596X
Editor: ALTEX Edition
DOI: 10.14573/ALTEX.2412171

Leveraging biomarkers and translational medicine for preclinical safety - Lessons for advancing the validation of alternatives to animal testing

Autores: Hartung T, King NMP, Kleinstreuer N, Leist M, Tagle DA
Publicado en: ALTEX, 2024, ISSN 1868-596X
Editor: ALTEX Edition
DOI: 10.14573/ALTEX.2410011

IHI VICT3R: Developing and Implementing Virtual Control Groups to Reduce Animal Use in Toxicology Research

Autores: Thomas Steger-Hartmann, Ferran Sanz, Frank Bringezu, Inari Soininen
Publicado en: Toxicologic Pathology, 2025, ISSN 0192-6233
Editor: SAGE Publications
DOI: 10.1177/01926233241303906

AI snake oil? A risk/benefit analysis for toxicology

Autores: Thomas Hartung, Mohan Rao, Mamta Behl, Alexandra Maertens
Publicado en: Frontiers in Artificial Intelligence, Edición 9, 2026, ISSN 2624-8212
Editor: Frontiers Media SA
DOI: 10.3389/FRAI.2026.1779276