Developing and implementing VIrtual Control groups To reducE animal use in toxicology Research

Informazioni relative al progetto

VICT3R

ID dell’accordo di sovvenzione: 101172693

DOI

10.3030/101172693

Data della firma CE 26 Luglio 2024

Data di avvio 1 Settembre 2024

Data di completamento 29 Febbraio 2028

Finanziato da

• Health

Costo totale

€ 26 995 885,75

Contributo UE

€ 13 524 750,00

Coordinato da

UNIVERSIDAD POMPEU FABRA
Spain

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (7)

Workshop with SEND experts

Summary of the outcomes of the workshop and proposed new terminology

Study designs overview

A report providing an overview on study designs across industries

First plan for dissemination and communication activities

Initial report on the communication strategy of the project, including the development of the initial tools

Identification of key covariates

Main covariates driving the variability of the endpoints measured in animals

Report on the data requirements and quality criteria

Definition of mandatory and optional fields in the VICOG DB

Computer system validation

Report on the CSV activities carried out for the software tool listed in D9.1

Academic landscape of animal-based studies

A report providing an overview on types and frequency of animal-based study designs in academia

Data Management Plan (1)

Initial Data Management Plan (DMP)

First report to gather the relevant aspects of making the data FAIR

Pubblicazioni

Peer reviewed articles (10)

Mapping out strategies to further develop human-relevant, new approach methodology (NAM)-based developmental neurotoxicity (DNT) testing

Autori: Eike, Cöllen; Kristina, Bartmann; Jonathan, Blum; Kelly, Carstens; Ivana, Celardo; Nivedita, Chatterjee; Marco, Corvaro; Nadine, Dreser; Ellen, Fritsche; Thomas, Hartung; Helena T, Hogberg; Thomas, K
Pubblicato in: ALTEX, 2025, ISSN 1868-596X
Editore: ALTEX Edition
DOI: 10.14573/ALTEX.2501091

The need for epigenotoxicity testing.

Autori: Hartung T, Smirnova L, Platz S, Amelio I, Leist M.
Pubblicato in: ALTEX, Numero 42, 2025, ISSN 1868-596X
Editore: ALtex Edition
DOI: 10.14573/ALTEX.2509281

Transitional initiatives for advancing the phasing out of the use of animals for drug and chemical safety testing: The IHI VICT3R project for reducing the use of animals by implementing virtual control groups

Autori: Ferran Sanz, Julia Matyjasiak, Javier Orihuel, Colleen M. Pike, Inari Soininen, Frank Bringezu, Olga Valverde, Mathieu Vinken, Janette Turner, Thomas Steger-Hartmann
Pubblicato in: NAM Journal, 2025, ISSN 3050-6204
Editore: Elsevier BV
DOI: 10.1016/J.NAMJNL.2025.100065

Challenges and opportunities for validation of AI-based new approach methods.

Autori: Hartung T, Kleinstreuer N.
Pubblicato in: ALTEX, Numero 42, 2025, ISSN 1868-596X
Editore: ALTEX Edition
DOI: 10.14573/ALTEX.2412291

The validation of regulatory test methods - Conceptual, ethical, and philosophical foundations.

Autori: Hartung T.
Pubblicato in: ALTEX, Numero 41, 2024, ISSN 1868-596X
Editore: Altex Edition
DOI: 10.14573/ALTEX.2409271

Virtual control groups in non-clinical toxicology – A replicability challenge.

Autori: Steger-Hartmann T, Duchateau-Nguyen G, Bringezu F, Onidi M, Stirn M.
Pubblicato in: ALTEX, 2025, ISSN 1868-8551
Editore: ALTEX
DOI: 10.14573/ALTEX.2503061

Integrative Data Science in Drug Safety Research: Experiences, Challenges, and Perspectives

Autori: Ferran Sanz
Pubblicato in: Annual Review of Biomedical Data Science, Numero 8, 2025, ISSN 2574-3414
Editore: Annual Reviews
DOI: 10.1146/ANNUREV-BIODATASCI-103123-095506

The long way from raw data to NAM-based information: Overview on data layers and processing steps

Autori: Blum J, Brüll M, Hengstler JG, Dietrich DR, Gruber AJ, Dipalo M, Kraushaar U, Mangas I, Terron A, Fritsche E, Marx-Stoelting P, Hardy B, Schepky A, Escher S, Hartung T, Landsiedel R, Odermatt A, Sach
Pubblicato in: ALTEX, Numero 42, 2025, ISSN 1868-596X
Editore: ALTEX Edition
DOI: 10.14573/ALTEX.2412171

Leveraging biomarkers and translational medicine for preclinical safety - Lessons for advancing the validation of alternatives to animal testing

Autori: Hartung T, King NMP, Kleinstreuer N, Leist M, Tagle DA
Pubblicato in: ALTEX, 2024, ISSN 1868-596X
Editore: ALTEX Edition
DOI: 10.14573/ALTEX.2410011

IHI VICT3R: Developing and Implementing Virtual Control Groups to Reduce Animal Use in Toxicology Research

Autori: Thomas Steger-Hartmann, Ferran Sanz, Frank Bringezu, Inari Soininen
Pubblicato in: Toxicologic Pathology, 2025, ISSN 0192-6233
Editore: SAGE Publications
DOI: 10.1177/01926233241303906