Joint Understanding and Analysis of clade I monkeypox epidemiology, evolution and immunology in South Kivu

Projektinformationen

JUA KIVU

ID Finanzhilfevereinbarung: 101195116

DOI

10.3030/101195116

EK-Unterschriftsdatum 4 Dezember 2024

Startdatum 1 Oktober 2024

Enddatum 30 September 2026

Finanziert unter

• Health

Gesamtkosten

€ 1 250 000,00

EU-Beitrag

€ 1 250 000,00

Koordiniert durch

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands

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Links zu Ergebnissen und Veröffentlichungen von RP7-Projekten sowie Links zu einigen Typen spezifischer Ergebnisse wie Datensätzen und Software werden dynamisch von OpenAIRE abgerufen.

Leistungen

Documents, reports (2)

Report on the set-up and validation of mpox serology on-site, using EMC reagents

Report on the set-up and validation of mpox serology on-site, using Erasmus MC reagents. This will include a description of the experience in setting up serological testing, the problems encountered and solutions for those problems.

Report on serological analysis of (biobanked) human samples

Report on serological analysis of (biobanked) human samples. This will include number of samples, sample types and the serological profiles thereof. This will provide insight into the early phase of the outbreak.

Websites, patent fillings, videos etc. (1)

Project website

Other (2)

Protocols to perform (comparative) immunological assays with Clade I MPXV

Protocols to perform (comparative) immunological assays with Clade I MPXV. These assays will determine binding and neutralising antibody levels, allowing assertion of clade I MPXV-specific humoral immune responses antibodies induced by infection and vaccination.

Exploitation and dissemination plan

Data Management Plan (1)

Data Management Plan

Veröffentlichungen

Peer reviewed articles (4)

Metagenomic sequencing of mpox virus clade Ib lesions identifies possible bacterial and viral co-infections in hospitalized patients in eastern DRC

Autoren: Leonard Schuele; Leandre Murhula Masirika; Hayley Cassidy; Philip T. L. C. Clausen; Luca M. Zaeck; Marjan Boter; Pacifique Ndishimye; Jean Claude Udahemuka; Rory D. de Vries; Saria Otani; Richard Molenkamp; David F. Nieuwenhuijse; Justin Bengehya Mbiribindi; Freddy Belesi Siangoli; Marion Koopmans; Frank M. Aarestrup; Bas B. Oude Munnink
Veröffentlicht in: Microbiology Spectrum, 2025, ISSN 2165-0497
Herausgeber: ASM Press
DOI: 10.1128/SPECTRUM.00512-25

Epidemiological and genomic evolution of the ongoing outbreak of clade Ib mpox virus in the eastern Democratic Republic of the Congo

Autoren: Leandre Murhula Masirika, Jean Claude Udahemuka, Leonard Schuele, David F. Nieuwenhuijse, Pacifique Ndishimye, Marjan Boter, Justin Bengehya Mbiribindi, Cris Kacita, Trudie Lang, Christian Gortázar,
Veröffentlicht in: Nature Medicine, Ausgabe 31, 2025, ISSN 1078-8956
Herausgeber: Springer Science and Business Media LLC
DOI: 10.1038/S41591-025-03582-1

Mpox: A case study for a one health approach to infectious disease prevention

Autoren: Hayman, David T.S.; Koopmans, Marion P.G.; Cunningham, Andrew A.; Bukachi, Salome A.; Masirika, Leandre Murhula; Markotter, Wanda; Mettenleiter, Thomas C.
Veröffentlicht in: One Health, 2025, ISSN 2352-7714
Herausgeber: Elsevier
DOI: 10.1016/J.ONEHLT.2025.101059

Serological evidence of clade Ib Mpox transmission by sex workers and within household in South Kivu, DRC

Autoren: Leandre Murhula Masirika, Luca M. Zaeck, Pacifique Ndishimye, Jean Claude Udahemuka, Saria Otani, Frank M. Aarestrup, Leonard Schuele, Babs E. Verstrepen, Scott Jones, Ashley Otter, Corine H. GeurtsvanKessel, Jean Pierre Musabyimana, Justin Bengehya Mbiribindi, Jules Minega Ndoli, Bas B. Oude Munnink, Freddy Siangoli Belesi, Marion P. G. Koopmans, Rory D. de Vries
Veröffentlicht in: Nature Communications, Ausgabe 16, 2025, ISSN 2041-1723
Herausgeber: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-62064-7