Joint Understanding and Analysis of clade I monkeypox epidemiology, evolution and immunology in South Kivu

Informazioni relative al progetto

JUA KIVU

ID dell’accordo di sovvenzione: 101195116

DOI

10.3030/101195116

Data della firma CE 4 Dicembre 2024

Data di avvio 1 Ottobre 2024

Data di completamento 30 Settembre 2026

Finanziato da

• Health

Costo totale

€ 1 250 000,00

Contributo UE

€ 1 250 000,00

Coordinato da

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (2)

Report on the set-up and validation of mpox serology on-site, using EMC reagents

Report on the set-up and validation of mpox serology on-site, using Erasmus MC reagents. This will include a description of the experience in setting up serological testing, the problems encountered and solutions for those problems.

Report on serological analysis of (biobanked) human samples

Report on serological analysis of (biobanked) human samples. This will include number of samples, sample types and the serological profiles thereof. This will provide insight into the early phase of the outbreak.

Websites, patent fillings, videos etc. (1)

Project website

Other (2)

Protocols to perform (comparative) immunological assays with Clade I MPXV

Protocols to perform (comparative) immunological assays with Clade I MPXV. These assays will determine binding and neutralising antibody levels, allowing assertion of clade I MPXV-specific humoral immune responses antibodies induced by infection and vaccination.

Exploitation and dissemination plan

Data Management Plan (1)

Data Management Plan

Pubblicazioni

Peer reviewed articles (4)

Metagenomic sequencing of mpox virus clade Ib lesions identifies possible bacterial and viral co-infections in hospitalized patients in eastern DRC

Autori: Leonard Schuele; Leandre Murhula Masirika; Hayley Cassidy; Philip T. L. C. Clausen; Luca M. Zaeck; Marjan Boter; Pacifique Ndishimye; Jean Claude Udahemuka; Rory D. de Vries; Saria Otani; Richard Molenkamp; David F. Nieuwenhuijse; Justin Bengehya Mbiribindi; Freddy Belesi Siangoli; Marion Koopmans; Frank M. Aarestrup; Bas B. Oude Munnink
Pubblicato in: Microbiology Spectrum, 2025, ISSN 2165-0497
Editore: ASM Press
DOI: 10.1128/SPECTRUM.00512-25

Epidemiological and genomic evolution of the ongoing outbreak of clade Ib mpox virus in the eastern Democratic Republic of the Congo

Autori: Leandre Murhula Masirika, Jean Claude Udahemuka, Leonard Schuele, David F. Nieuwenhuijse, Pacifique Ndishimye, Marjan Boter, Justin Bengehya Mbiribindi, Cris Kacita, Trudie Lang, Christian Gortázar,
Pubblicato in: Nature Medicine, Numero 31, 2025, ISSN 1078-8956
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41591-025-03582-1

Mpox: A case study for a one health approach to infectious disease prevention

Autori: Hayman, David T.S.; Koopmans, Marion P.G.; Cunningham, Andrew A.; Bukachi, Salome A.; Masirika, Leandre Murhula; Markotter, Wanda; Mettenleiter, Thomas C.
Pubblicato in: One Health, 2025, ISSN 2352-7714
Editore: Elsevier
DOI: 10.1016/J.ONEHLT.2025.101059

Serological evidence of clade Ib Mpox transmission by sex workers and within household in South Kivu, DRC

Autori: Leandre Murhula Masirika, Luca M. Zaeck, Pacifique Ndishimye, Jean Claude Udahemuka, Saria Otani, Frank M. Aarestrup, Leonard Schuele, Babs E. Verstrepen, Scott Jones, Ashley Otter, Corine H. GeurtsvanKessel, Jean Pierre Musabyimana, Justin Bengehya Mbiribindi, Jules Minega Ndoli, Bas B. Oude Munnink, Freddy Siangoli Belesi, Marion P. G. Koopmans, Rory D. de Vries
Pubblicato in: Nature Communications, Numero 16, 2025, ISSN 2041-1723
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-62064-7