Objective
By combining advanced synthetic chemistry with cancer biology, we have demonstrated the potential of ruthenium complex IGN116 as an effective and tolerable anticancer agent, inhibiting tumour proliferation as early as 1-2 days post treatment in pre-clinical PDX models. Instead of acting as a cytotoxic agent, IGN116 interferes with the key bioenergetic pathway (aerobic oxidative phosphorylation) utilized by Cancer Stem Cells (CSC), drastically effecting their stemness potential whilst keeping other cells essentially unaffected. This mode of action is novel both among organometallic and CSC-targeting drugs, conferring IGN116s effectivity with unmatched low secondary toxicity. Through its unique mechanism of action, IGN116 provides the opportunity to tackle the specific therapeutic challenges of two particularly concerning cancer types that will be the focus of MEDICS: Therapy resistance in the high incidence CRC (1.9 million new cases and 608,000 deaths/year); and poor prognosis in treatment-refractory PDAC (495,773 cases, 466,003 deaths/year). The current TRL is at 3-4 having demonstrated in vivo efficacy, confirmed mechanism of action, and completed full toxicity pharmacokinetic (PK) studies of the isolated IGN116, both in in-house studies and in external CRO-led validation. In MEDICS, we will further develop IGN116 for CRC and PDAC progressing towards TRL5 through: Development of a scalable manufacturing process amenable to GMP; Advancement towards GLP in-vivo studies; and Creation of a spin-out to take the product development towards commercialization. MEDICS will thus tackle a critical challenge in European healthcare: delivering safe and effective cancer treatments, with the potential of benefitting 43,800 CRC and PDAC patients per year in Europe alone by 2040.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences inorganic chemistry transition metals
- medical and health sciences clinical medicine oncology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.3.1 - The European Innovation Council (EIC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-EIC - HORIZON EIC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-EIC-2024-TRANSITION-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
15782 SANTIAGO DE COMPOSTELA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.