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Neuronal circuits underlying individual learning trajectories

Project description

Dopamine and learning styles

Individuals have very different learning styles, and as they advance from beginners to experts, they follow different paths. Although this diversity is evident in classrooms and workplaces, the brain mechanisms that shape individual learning trajectories remain unclear. Recent research in mice shows that dopamine signals in the brain serve as teaching cues that direct these transitions. The ERC-funded LearningTrajectories project proposes that brain circuits are affected by different dopamine signals, leading to varied learning strategies. Research into the interactions between various brain regions will reveal how particular neural circuits influence individual learning trajectories. Collectively, project findings will also provide important insight into how cognitive disorders impact adaptive learning.

Objective

Individuals learn in drastically diverse ways, whether at school, at work or when pursuing their hobby. In their journey from naïve to expert individuals discover distinct strategies for learning, forming diverse learning trajectories. However, the neuronal circuit computations that account for these learning trajectories are poorly understood. My lab's recent work found that in learning to make visual decisions from naïve to expert mice transition through sequence of strategies, showing substantial individual diversity in their learning trajectories. We discovered that dopamine signals in the dorsal striatum act as teaching signals that guide individual learning trajectories. Building up on these, I hypothesize that dopamine neurons broadcast heterogenous teaching signals that regulate neuronal responses within distinct striatal and frontal circuits, promoting different strategies during learning and governing diverse learning trajectories. We will test this overarching hypothesis in the following aims:

I) Establish whether dopamine signals arriving in different striatal and cortical regions play separate roles in governing learning trajectories.
II) Define frontal cortical signals during learning, and identify the role of distinct frontostriatal circuits in guiding learning.
III) Determine the contribution of distinct striatal circuits in shaping individual learning trajectories.

The project delivers unparalleled insights into neuronal circuit computations underlying individual learning trajectories from naïve to expert, and may offer insights into cognitive disorders linked to failures in these processes.

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Call for proposal

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(opens in new window) ERC-2025-COG

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Host institution

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 1 996 864,00
Address
WELLINGTON SQUARE UNIVERSITY OFFICES
OX1 2JD Oxford
United Kingdom

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Region
South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 1 996 864,00

Beneficiaries (1)

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