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DEVELOPMENT OF A NANOHYBRID SYSTEM BASED WEARABLE MICROFLUIDIC PHOTOELECTROCHEMICAL SENSOR FOR THE ON-DEMAND cTnI DETECTION (NANOPEC)

Ziel

Development of a Nanohybrid System Based Wearable Microfluidic Photoelectrochemical Sensor for the On-Demand cTnI Detection

The Acute Myocardial Infarction (AMI) demands instant diagnosis, since the currently existing technologies remain invasive, expensive, time-consuming, and confined to clinical setups. The project NANOPEC proposed for the MSCA PF application hosts an innovative solution with the development of a wearable, biorecognition-free, microfluidic photoelectrochemical (PEC) saliva sensor for the ultrasensitive detection of cardiac troponin (cTnI). Fundamentally, it lies in a unique zinc oxide tetrapod-graphene quantum dot (ZnOTPD/GQD)-based nanohybrid system, while GQD will be derived sustainably from plastic waste. Embedding this into a flexible, wearable patch will enable the on-demand real-time monitoring of cTnI levels. This project relies on the following key deliverables: Development of GQD with quantum yield > 50% with photoinduced charge transfer efficiency over 85% within the nanohybrid, Fabrication of a durable, microfluidic PEC patch withstanding at least 50 cycles while keeping a stable performance, ultrasensitive detection with an expected limit of detection < 5 pg/ml, and validation of the sensor performance with artificial saliva matrices with reproducibility (expected RSD under 8%) and robustness against common interfering analytes. By interlinking nanotechnology, material science, and wearable diagnostics, NANOPEC will open up a way for a low-cost, scalable, sustainable, non-invasive, on-set diagnostic tool, which will improve clinical outcomes and reduce the global mortality rate.

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Schlüsselbegriffe

Programm/Programme

Thema/Themen

Finanzierungsplan

HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships

Alle im Rahmen dieses Finanzierungsinstruments finanzierten Projekte anzeigen

Aufforderung zur Vorschlagseinreichung

(öffnet in neuem Fenster) HORIZON-MSCA-2025-PF

Alle im Rahmen dieser Aufforderung zur Einreichung von Vorschlägen finanzierten Projekte anzeigen

Koordinator

KAUNO TECHNOLOGIJOS UNIVERSITETAS
Netto-EU-Beitrag
€ 196 976,16
Adresse
K DONELAICIO 73
LT-44029 Kaunas
Litauen
Region
Lietuva Vidurio ir vakarų Lietuvos regionas Kauno apskritis
Aktivitätstyp
Higher or Secondary Education Establishments
Links
Gesamtkosten
Keine Daten

Partner (2)