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DEVELOPMENT OF A NANOHYBRID SYSTEM BASED WEARABLE MICROFLUIDIC PHOTOELECTROCHEMICAL SENSOR FOR THE ON-DEMAND cTnI DETECTION (NANOPEC)

Obiettivo

Development of a Nanohybrid System Based Wearable Microfluidic Photoelectrochemical Sensor for the On-Demand cTnI Detection

The Acute Myocardial Infarction (AMI) demands instant diagnosis, since the currently existing technologies remain invasive, expensive, time-consuming, and confined to clinical setups. The project NANOPEC proposed for the MSCA PF application hosts an innovative solution with the development of a wearable, biorecognition-free, microfluidic photoelectrochemical (PEC) saliva sensor for the ultrasensitive detection of cardiac troponin (cTnI). Fundamentally, it lies in a unique zinc oxide tetrapod-graphene quantum dot (ZnOTPD/GQD)-based nanohybrid system, while GQD will be derived sustainably from plastic waste. Embedding this into a flexible, wearable patch will enable the on-demand real-time monitoring of cTnI levels. This project relies on the following key deliverables: Development of GQD with quantum yield > 50% with photoinduced charge transfer efficiency over 85% within the nanohybrid, Fabrication of a durable, microfluidic PEC patch withstanding at least 50 cycles while keeping a stable performance, ultrasensitive detection with an expected limit of detection < 5 pg/ml, and validation of the sensor performance with artificial saliva matrices with reproducibility (expected RSD under 8%) and robustness against common interfering analytes. By interlinking nanotechnology, material science, and wearable diagnostics, NANOPEC will open up a way for a low-cost, scalable, sustainable, non-invasive, on-set diagnostic tool, which will improve clinical outcomes and reduce the global mortality rate.

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Parole chiave

Programma(i)

Argomento(i)

Meccanismo di finanziamento

HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships

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Invito a presentare proposte

(si apre in una nuova finestra) HORIZON-MSCA-2025-PF

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Coordinatore

KAUNO TECHNOLOGIJOS UNIVERSITETAS
Contributo netto dell'UE
€ 196 976,16
Indirizzo
K DONELAICIO 73
LT-44029 Kaunas
Lituania
Regione
Lietuva Vidurio ir vakarų Lietuvos regionas Kauno apskritis
Tipo di attività
Higher or Secondary Education Establishments
Collegamenti
Costo totale
Nessun dato

Partner (2)