Objective
Prostate cancer (PCa) is the second most common malignancy in men and a major cause of cancer mortality. In metastatic castration-resistant PCa (mCRPC), therapeutic resistance almost invariably arises, highlighting the urgent need for transformative interventions. This project addresses this challenge by advancing chemically induced proximity (CIP) through Regulated Induced Proximity Targeting Chimeras (RIPTACs), a disruptive novel drug modality that harnesses the enforced proximity of disease-relevant proteins with pan-essential proteins (EPs) to trigger selective cell death, independently of E3 ligases or proteasomal degradation.
The project will pioneer polyvalent RIPTACs, introducing first-in-class trivalent and tetravalent designs to maximize avidity, multifunctionality, and precision. Grounded in principles of polypharmacology, these constructs will integrate complementary mechanisms within single molecular entities, combining tumor targeting with immune checkpoint modulation, metabolic interference, and pathway-selective inhibition. By creating novel proximities between proteins not normally associated, RIPTACs can reprogram cellular networks and unlock entirely new therapeutic routes, expanding the possibilities of intervention in complex biological systems. Novel RIPTACs will be designed, assembled through modular synthetic platforms and validated using advanced biophysical, biochemical, and phenotypic assays in cutting-edge PCa models, both extracellular and intracellular. This strategy expands the pharmacological space of CIP-based therapeutics, offering unprecedented structural and functional versatility. The expected outcomes include lead compounds with superior potency, selectivity, and pharmacokinetic properties, able to overcome resistance while minimizing systemic toxicity.
This project pioneers polyvalent RIPTACs to unlock new therapies, advance translation, and propel my path to independence.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- social sciences sociology demography mortality
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine oncology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
15782 SANTIAGO DE COMPOSTELA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.