Imaging Biomarkers (IBs) for Safer Drugs: Validation of Translational Imaging Methods in Drug Safety Assessment - Sofia ref.: 116106 | IB4SD-TRISTAN | Progetto | Risultati | H2020 | CORDIS

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Manuscript for a review on current 89Zr chelates for protein labeling

Migration

Manuscript on novel 89Zr-GLP-1 peptide conjugation

An ARRIVE-compliant manuscript submitted for open-access publication describing the design and synthesis the GLP-1 site-specifically conjugated to the optimised 89Zr chelate, the design and synthesis the GLP-1 site-specifically conjugated to IRDye 800CW, molecular integrity and stability of GLP-1 conjugates analytically verified through LC-MS, in vitro evaluation of properties of 89Zr-labelled GLP-1 conjugate: chemical purity, stability, degradation, suitability for in vivo administration, in vivo evaluation of properties of 89Zr-labelled GLP-1 conjugate and IRDye 800CW GLP-1 conjugate Responsible for coordinating and assembling entire manuscript: DijonVerification: (1) PDF of manuscript; (2) Email from journal acknowledging receipt of manuscript; (3) Minutes of WP4 meeting prospectively justifying sample size for animal experiments; (4) A copy of the page on the TRISTAN data inventory (5.0.D1) which shows a record for the data acquired in order to generate this deliverable; (5) url of the site (5.0.D4) containing any SOPs and any exemplar data-sets associated with this deliverable.Responsible for mouse imaging: NijmegenResponsible for analytic verification: NijmegenGNG 4.1.G4: Thermodynamic and kinetic stability of 89Zr in these novel chelates in blood (in vitro) as well as physicochemical properties of labeled compounds should jusify further animal experiments Site-specific conjugated 89Zr-conjugated GLP-1 and the fluorescent analogue, in vitro are impressive enough to justify further animal experimentsVerification: Minutes of WP4 meetingConsequence: If conjugate is unimpressive, previously existing Zr chelates will be used for further studiesDate: M18

Final dissemination and exploitation plan

final dissemination and exploitation plan

Manuscript on chronic bleomycin MR&PET

An ARRIVE-compliant manuscript submitted for open-access publication which (a) characterizes the progression of bleomycin-induced lung inflammation and fibrosis in rats using suitable imaging biomarkers employing 1H-MRI and PET/CT using tracers for inflammation (e.g. FDG), and for structural change (e.g. collagen 1) (b) correlates imaging biomarkers with conventional evaluation such as histology, cells, and protein expression; If the studies are negative, report of the negative findings.Responsible: Lund/TrulyVerification: (1) Minutes of WP3 meeting (2) Pdf of manuscript; (3) Email from journal acknowledging receipt of manuscriptDate: M42GNG 3.3.G1 GO: PET/CT or MRI biomarkers improve the characterization of progression in rats of bleomycin-induced lung inflammation vs fibrosis. Verification: Minutes of WP3 Date: M24Consequence: If the imaging biomarkers are uninformative, NO-GO for multisite preclinical evaluation

manuscript on food effects on BSEP function in patients

A manuscript submitted for open-access publication describing food effects in healthy volunteers on the basal activity of BSEP. This deliverable is conditional and subject to Pfizer internal approval as well as to approval by the EMAResponsible: PfizerVerification: (1) pdf of manuscript; (2) email from journal acknowledging receipt of submitted manuscript; (3) prospective study protocol and sample size (power) calculation appended to WP2 minutes; (4) clinical trial identification number from a recognised clinical trial registry such as clinicaltrials.gov; (5) A copy of the page on the TRISTAN data inventory (5.0.D1) which shows a record for the data acquired in order to generate this deliverable; (6) url of the site (5.0.D4) containing any SOPs and any exemplar data-sets associated with this deliverable ; (7) the data sharing statement..

Review 1 for liver transporter assessment by imaging

Migration

Final data management plan

final data management plan

Manuscript on use of 89Zr pembrolizumab in NHPs

An ARRIVE-compliant manuscript submitted for open-access publication describing 89Zr-pembrolizuab in NHPResponsible: MSDVerification: (1) Minutes of WP4 meeting including prospective sample size calculation and prospective protocol; (2) Opinion of TRISTAN’s independent Ethics Advisory Board that use of NHP is justified in the context of the entire project goals; (3) PDF of manuscript; (4) Email from journal acknowledging receipt of manuscript; (4) A copy of the page on the TRISTAN data inventory (5.0.D1) which shows a record for the data acquired in order to generate this deliverable; (5) url of the site (5.0.D4) containing any SOPs and any exemplar data-sets associated with this deliverable.GNG 4.3.G3: In vivo experiments in NHP justify a clinical studyVerification: Minutes of WP4 meetingConsequence: Non-human primate study will not be performedDate: M29

Manuscript on physician approaches to DIILD

A survey of physician approaches to treatment of DIILD from drugs with known DIILD risk, submitted for open-access publication Responsible for coordinating and assembling entire manuscript: SheffieldResponsible for contributing Sheffield, Bioxydyn, Manchester, Verification: (1) Pdf of manuscript; (2) Email from journal acknowledging receipt of manuscript

Manuscript on imaging cellular vs non-cellular components

An ARRIVE-compliant manuscript submitted for open-access publication whichcharacterizes the set-up and characterization of cellular vs. non-cellular components of chronic bleomycin-induced lung fibrosis in rats using (a) suitable 1H-MRI and/or PET imaging biomarkers and (b) discusses implications for clinical assessment, (c) correlates imaging biomarkers with conventional evaluation such as histology, cells, protein expression and ‘lung function’. Reports to include also negative findings.Responsible for coordinating and assembling entire manuscript: Lund/TrulyVerification: (1) Minutes of WP3 meeting including prospective sample size calculation and prospective protocol; (2) Pdf of manuscript; (3) Email from journal acknowledging receipt of manuscriptGNG 3.3 G2: GO: Novel chronic bleomycin model improves the translatability of animal model to clinical setting. Imaging biomarkers suing MRI and/or PET/CT improve characterization of cellular vs. non-cellular components of bleomycin-induced lung fibrosis in a chronic rat model. Verification: (1) Minutes of WP3 meeting Consequence: If the imaging biomarkers are uninformative: NO-GO for multisite preclinical evaluation; NO-GO for progression into manDate: M36

Manuscript on novel 89Zr chelates for protein labeling

Migration

Manuscript on the progression of bleomycin induced inflammation and fibrosis in rats imaged by MRI/CT

Migration

Manuscript on simplified IL2 labeling method

A manuscript submitted for open-access publication describing a simplified method that could be applied in multicentre studies to produce a 68Ga or 18F-labelled IL2-based PET tracer.Responsible for coordinating and assembling entire manuscript: NijmegenResponsible for contributing: GroningenVerification: (1) PDF of manuscript; (2) Email from journal acknowledging receipt of manuscript; (3) A copy of the page on the TRISTAN data inventory (5.0.D1) which shows a record for the data acquired in order to generate this deliverable; (4) url of the site (5.0.D4) containing any SOPs and any exemplar data-sets associated with this deliverable.GNG 4.3.G1: a simplified method that could be applied in multicentre studies to produce a 68Ga or 18F-labelled IL2-based PET tracerVerification: Minutes of WP4 meetingConsequence: IL2 tracer will not be used in 4.3.D2Date: M18

Manuscript for gadoxetate relaxivities

A manuscript submitted for open-access publication reporting the different relaxivities of gadoxetate between extra- and intracellular space characterised by in vitro studies at relevant field strengths. May be either a stand-alone manuscript or alternatively included as a section or supplementary material in a broader manuscript.Responsible for coordinating work assembling entire manuscript: Bayer Responsible for contributing data: Bayer, MSD, SanofiVerification: (1) pdf of manuscript; (2) email from journal acknowledging receipt of submitted manuscript; (3) A copy of the page on the TRISTAN data inventory (5.0.D1) which shows a record for the data acquired in order to generate this deliverable.

Workplan for pre-clinical BSEP-probe evaluation

Migration

Manuscript for phantom imaging reproducibility

Migration

Manuscript for reviews on ILD imaging in humans

Migration

Paravision software integration

Smooth integration and/or interfacing of the software developed for deliverable 5.2.D1 into/with the ParaVision workflow for providing ease of use, error prevention and reproducibilityResponsible: BrukerVerification: (1) pdf application notes; (2) url of site.

Paravision protocol integration

The final protocols, procedures and other software components developed for deliverables 5.2.D3, 5.2.D5 and 5.2.D9 should be available for download on Bruker website or distributed via Bruker hotline. Responsible: BrukerVerification: Announcement on Bruker website.

Pre-clinical gadoxetate MRI assay commercially available

A valid gadoxetate assay in rats offered as a commercial serviceResponsible: AntarosVerification: service offered by company on their website.

Phantom QC for rat MRI scanner stability over time

Migration

Phantom QC for clinical MRI scanner stability over time

Migration

Simplified procedures for in vitro and in vivo biologics bio-distribution analysis available on website

software implementation of the simplified procedures uploaded to a recognised open-access site, together with fit-for-purpose application notes and test data, and successfully executed independently by one other consortium memberResponsible for upload and application notes: GroningenResponsible for testing: NijmegenVerification: (1) PDF application notes; (2) URL of site; (3) PDF of successful test output

Clinical gadoxetate MRI assay commercially available

A valid gadoxetate assay in humans offered as commercial serviceResponsible: BioxydynVerification: service offered by company on their website.

Gadoxetate imaging model software

Migration

Open-access website for validation SOP download

Migration

Pre-clinical safety test for DIILD

For the most promising and or highest priority imaging biomarkers selected from those evaluated in deliverables D3.10 (3.03D1)- D3.16 (3.03D12) a commercial test is offered for preclinical safety evaluation.Responsible: TrulyVerification: Service offered on the companys website

Free-breathing 3D acquisition protocol for clinical MRI

Migration

Paravision add-in for liver transporter analysis

Software components for storage and re-usage of applied animal imaging workflow including study planning (requested procedures), scan execution and post-processing procedure steps and workflow documentation (with, among others, animal & scanner status, scan setup, postprocessing descriptions)Responsible: BrukerVerification: (1) pdf application notes; (2) url of site.

Quantitative clinical DIILD MRI offered commercially

Quantitative DIILD MRI offered as a commercial serviceResponsible: BioxydynVerification: service offered on companys website

optimized data acquisition of 129 Xe MRI

Migration

Free-breathing 3D acquisition protocol for pre-clinical MRI

Migration

Pubblicazioni

Imaging Biomarkers and Pathobiological Profiling in a Rat Model of Drug-Induced Interstitial Lung Disease Induced by Bleomycin

Autori: Irma Mahmutovic Persson, Hanna Falk Håkansson, Anders Örbom, Jian Liu, Karin von Wachenfeldt, Lars E. Olsson
Pubblicato in: Frontiers in Physiology, Numero 11, 2020, ISSN 1664-042X
Editore: Frontiers Research Foundation
DOI: 10.3389/fphys.2020.00584

Comparison of the Tissue Distribution of a Long-Circulating Glucagon-like Peptide-1 Agonist Determined by Positron Emission Tomography and Quantitative Whole-Body Autoradiography

Autori: Eduardo Felipe Alves Fernandes,*,‡ Jonas Wilbs,*,‡ Rene Raavé, Christian Borch Jacobsen, Hanne Toftelund, Hans Helleberg, Milou Boswinkel, Sandra Heskamp, Magnus Bernt Frederik Gustafsson, and Inga Bjørnsdottir
Pubblicato in: ACS Pharmacol. Transl. Sci., 2022, ISSN 2575-9108
Editore: American Chemical Society
DOI: 10.1021/acsptsci.2c00075

Survey of water proton longitudinal relaxation in liver in vivo

Autori: John Charles Waterton
Pubblicato in: Magnetic Resonance Materials in Physics, Biology and Medicine, Numero 34(6), 2021, ISSN 2213-7793
Editore: Springer
DOI: 10.1007/s10334-021-00928-x

Development and Evaluation of Interleukin-2–Derived Radiotracers for PET Imaging of T Cells in Mice

Autori: Elly L. van der Veen, Frans V. Suurs, Frederik Cleeren, Guy Bormans, Philip H. Elsinga, Geke A.P. Hospers, Marjolijn N. Lub-de Hooge, Elisabeth G.E. de Vries, Erik F.J. de Vries, Inês F. Antunes
Pubblicato in: Journal of Nuclear Medicine, Numero 61/9, 2020, Pagina/e 1355-1360, ISSN 0161-5505
Editore: Kexue Chubaneshe/Science Press
DOI: 10.2967/jnumed.119.238782

Manual Versus Artificial Intelligence-Based Segmentations as a Pre-processing Step in Whole-body PET Dosimetry Calculations.

Autori: van Sluis J, Noordzij W, de Vries EGE, Kok IC, de Groot DJA, Jalving M, Lub-de Hooge MN, Brouwers AH, Boellaard R
Pubblicato in: Mol Imaging Biol., 2023, ISSN 2193-1801
Editore: Springer Science and Business Media Deutschland GmbH
DOI: 10.1007/s11307-022-01775-5

Imaging biomarkers of lung ventilation in interstitial lung disease from 129Xe and oxygen enhanced 1H MRI

Autori: Tibiletti M, Eaden JA, Naish JH, Hughes PJC, Waterton JC, Heaton MJ, Chaudhuri N, Skeoch S, Bruce IN, Bianchi S, Wild JM, Parker GJM.
Pubblicato in: Magnetic Resonance Imaging, 2023, ISSN 0346-251X
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.mri.2022.10.005

Physiologically Based Pharmacokinetic Modeling of Transporter-Mediated Hepatic Disposition of Imaging Biomarker Gadoxetate in Rats

Autori: Daniel Scotcher, Nicola Melillo, Sirisha Tadimalla, Adam S. Darwich, Sabina Ziemian, Kayode Ogungbenro, Gunnar Schütz, Steven Sourbron, and Aleksandra Galetin
Pubblicato in: Mol. Pharmaceutics, Numero 18, 8, 2021, ISSN 1543-8384
Editore: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.1c00206

Site-Specific, Platform-Based Conjugation Strategy for the Synthesis of Dual-Labeled Immunoconjugates for Bimodal PET/NIRF Imaging of HER2-Positive Tumors

Autori: Pierre Adumeau, René Raavé, Milou Boswinkel, Sandra Heskamp, Hans J. C. T. Wessels, Alain J. van Gool, Mathieu Moreau, Claire Bernhard, Laurène Da Costa, Victor Goncalves, and Franck Denat
Pubblicato in: Bioconjugate Chem., 2022, ISSN 1520-4812
Editore: American Chemical Society
DOI: 10.1021/acs.bioconjchem.2c00049

<sup>89</sup>Zr-pembrolizumab biodistribution is influenced by PD-1-mediated uptake in lymphoid organs

Autori: Elly L van der Veen, Danique Giesen, Linda Pot-de Jong, Annelies Jorritsma-Smit, Elisabeth G E De Vries, Marjolijn N Lub-de Hooge
Pubblicato in: Journal for ImmunoTherapy of Cancer, Numero 8, 2020, Pagina/e e000938, ISSN 2051-1426
Editore: BMJ
DOI: 10.1136/jitc-2020-000938

In Vivo PET Imaging of Monocytes Labeled with [89Zr]Zr-PLGA-NH2 Nanoparticles in Tumor and Staphylococcus aureus Infection Models

Autori: Massis Krekorian, Kimberley R. G. Cortenbach, Milou Boswinkel, Annemarie Kip, Gerben M. Franssen, Andor Veltien, Tom W. J. Scheenen, René Raavé, Nicolaas Koen van Riessen, Mangala Srinivas, Ingrid Jolanda M. de Vries, Carl G. Figdor, Erik H. J. G. Aarntzen, Sandra Heskamp
Pubblicato in: Cancers, Numero 13, 2024, Pagina/e 5069, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13205069

89Zr-pembrolizumab imaging as a non-invasive approach to assess clinical response to PD-1 blockade in cancer

Autori: I. C. Kok, J. S. Hooiveld, P. P. van de Donk1y, D. Giesen1, E. L. van der Veen, M. N. Lub-de Hooge2, A. H. Brouwers, T. J. N. Hiltermann, A. J. van der Wekken4, L. B. M. Hijmering-Kappelle, W. Timens, S. G. Elias, G. A. P. Hospers, H. J. M. Groen, W. Uyterlinde, B. van der Hiel8, J. B. Haanen, D. J. A. de Groot, M. Jalving & E. G. E. de Vries
Pubblicato in: Annals of Oncology, Numero VOLUME 33, ISSUE 1, P80-88, 2021, ISSN 0923-7534
Editore: Oxford University Press
DOI: 10.1016/j.annonc.2021.10.213

Time of Flight Secondary Ion Mass Spectrometry imaging for precise localization of zirconium-labelled trastuzumab in xenograft cancer tumour tissues

Autori: Florent Penen, René Raavé, Annemarie Kip, Sandra Heskamp, Per Malmberg
Pubblicato in: Microchemical Journal, Numero 181, 2025, Pagina/e 107860, ISSN 0026-265X
Editore: Elsevier BV
DOI: 10.1016/j.microc.2022.107860

A Dual-Channel Deep Learning Approach for Lung Cavity Estimation From Hyperpolarized Gas and Proton MRI

Autori: Joshua R. Astley BEng, Alberto M. Biancardi PhD, Helen Marshall PhD, Paul J. C. Hughes PhD, Guilhem J. Collier PhD, Laurie J. Smith PhD, James A. Eaden PhD, Rod Hughes MD, Jim M. Wild PhD, Bilal A. Tahir PhD
Pubblicato in: JMRI, 2023, ISSN 1053-1807
Editore: John Wiley & Sons Inc.
DOI: 10.1002/jmri.28519

Contrast enhanced longitudinal changes observed in an experimental bleomycin-induced lung fibrosis rat model by radial DCE-MRI at 9.4T

Autori: René in ‘t Zandt, Irma Mahmutovic Persson, Marta Tibiletti, Karin von Wachenfeldt, Geoff J. M. Parker, Lars E. Olsson, null null
Pubblicato in: PLOS ONE, Numero 19, 2024, Pagina/e e0310643, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0310643

Use of In Vivo Imaging and Physiologically-Based Kinetic Modelling to Predict Hepatic Transporter Mediated Drug–Drug Interactions in Rats

Autori: Melillo N, Scotcher D, Kenna JG, Green C, Hines CDG, Laitinen I, Hockings PD, Ogungbenro K, Gunwhy ER, Sourbron S, Waterton JC, Schuetz G, Galetin A.
Pubblicato in: Pharmaceutics, Numero 2023 Mar 10;15(3), 2023, Pagina/e 896, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15030896

Implementable Deep Learning for Multi-sequence Proton MRI Lung Segmentation: A Multi-center, Multi-vendor, and Multi-disease Study.

Autori: Astley JR, Biancardi AM, Hughes PJC, Marshall H, Collier GJ, Chan HF, Saunders LC, Smith LJ, Brook ML, Thompson R, Rowland-Jones S, Skeoch S, Bianchi SM, Hatton MQ, Rahman NM, Ho LP, Brightling CE, Wain LV, Singapuri A, Evans RA, Moss AJ, McCann GP, Neubauer S, Raman B; C-MORE/PHOSP-COVID Collaborative Group;Wild JM, Tahir BA.
Pubblicato in: J Magn Reson Imaging, 2023, ISSN 1053-1807
Editore: John Wiley & Sons Inc.
DOI: 10.1002/jmri.28643

Ex vivo gadoxetate relaxivities in rat liver tissue and blood at five magnetic field strengths from 1.41 to 7 T

Autori: Sabina Ziemian, Claudia Green, Steven Sourbron, Gregor Jost, Gunnar Schütz, Catherine D.G. Hines
Pubblicato in: NMR in Biomedicine, Numero 34/1, 2021, ISSN 0952-3480
Editore: John Wiley & Sons Inc.
DOI: 10.1002/nbm.4401

Imaging Biomarkers in Animal Models of Drug-Induced Lung Injury: A Systematic Review

Autori: Irma Mahmutovic Persson, Karin von Wachenfeldt, John C. Waterton, Lars E. Olsson
Pubblicato in: J. Clin. Med., Numero 10(1), 107, 2021, ISSN 2077-0383
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm10010107

Longitudinal Imaging Using PET/CT with Collagen-I PET-Tracer and MRI for Assessment of Fibrotic and Inflammatory Lesions in a Rat Lung Injury Model

Autori: Irma Mahmutovic Persson, Nina Fransén Pettersson, Jian Liu, Hanna Falk Håkansson, Anders Örbom, René In ’t Zandt, Ritha Gidlöf, Marie Sydoff, Karin von Wachenfeldt, Lars E. Olsson
Pubblicato in: Journal of Clinical Medicine, Numero 9/11, 2020, Pagina/e 3706, ISSN 2077-0383
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm9113706

PET/CT Imaging of 89Zr-N-sucDf-Pembrolizumab in Healthy Cynomolgus Monkeys

Autori: Wenping Li, Yuchuan Wang, Daniel Rubins, Idriss Bennacef, Marie Holahan, Hyking Haley, Mona Purcell, Liza Gantert, SuChun Hseih, Michael Judo, Wolfgang Seghezzi, Shuli Zhang, Elly L. van der Veen, Marjolijn N. Lub-de Hooge, Elisabeth G.E. de Vries, Jeffrey L. Evelhoch, Michael Klimas, Eric D. Hostetler
Pubblicato in: Molecular Imaging and Biology, Numero 23/2, 2021, Pagina/e 250-259, ISSN 1536-1632
Editore: Elsevier BV
DOI: 10.1007/s11307-020-01558-w

Assessment of hepatic transporter function in rats using dynamic gadoxetate-enhanced MRI: a reproducibility study

Autori: Ebony R. Gunwhy, Catherine D. G. Hines, Claudia Green, Iina Laitinen, Sirisha Tadimalla, Paul D. Hockings, Gunnar Schütz, J. Gerry Kenna, Steven Sourbron, John C. Waterton
Pubblicato in: Magnetic Resonance Materials in Physics, Biology and Medicine, Numero 37, 2024, Pagina/e 697-708, ISSN 1352-8661
Editore: Springer
DOI: 10.1007/s10334-024-01192-5

89 Zr-Immuno-Positron Emission Tomography in Oncology: State-of-the-Art 89 Zr Radiochemistry

Autori: Sandra Heskamp, René Raavé, Otto Boerman, Mark Rijpkema, Victor Goncalves, Franck Denat
Pubblicato in: Bioconjugate Chemistry, Numero 28/9, 2017, Pagina/e 2211-2223, ISSN 1043-1802
Editore: American Chemical Society
DOI: 10.1021/acs.bioconjchem.7b00325

Drug-Induced Interstitial Lung Disease: A Systematic Review

Autori: Sarah Skeoch, Nicholas Weatherley, Andrew Swift, Alexander Oldroyd, Christopher Johns, Conal Hayton, Alessandro Giollo, James Wild, John Waterton, Maya Buch, Kim Linton, Ian Bruce, Colm Leonard, Stephen Bianchi, Nazia Chaudhuri
Pubblicato in: Journal of Clinical Medicine, Numero 7/10, 2018, Pagina/e 356, ISSN 2077-0383
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm7100356

Synthesis and evaluation of zirconium-89 labelled and long-lived GLP-1 receptor agonists for PET imaging

Autori: Christian Borch Jacobsen, René Raavé, Marie Østergaard Pedersen, Pierre Adumeau, Mathieu Moreau, Ibai E. Valverde, Inga Bjørnsdottir, Jesper Bøggild Kristensen, Mette Finderup Grove, Kirsten Raun, James McGuire, Victor Goncalves, Sandra Heskamp, Franck Denat, Magnus Gustafsson
Pubblicato in: Nuclear Medicine and Biology, Numero 82-83, 2020, Pagina/e 49-56, ISSN 0969-8051
Editore: Elsevier BV
DOI: 10.1016/j.nucmedbio.2019.11.006

Tracers for non-invasive radionuclide imaging of immune checkpoint expression in cancer

Autori: Peter Wierstra, Gerwin Sandker, Erik Aarntzen, Martin Gotthardt, Gosse Adema, Johan Bussink, René Raavé, Sandra Heskamp
Pubblicato in: EJNMMI Radiopharmacy and Chemistry, Numero 4/1, 2019, ISSN 2365-421X
Editore: Springer Nature
DOI: 10.1186/s41181-019-0078-z

Clinical-grade N-(4-[18F]fluorobenzoyl)-interleukin-2 for PET imaging of activated T-cells in humans

Autori: Elly L. van der Veen, Inês F. Antunes, Petra Maarsingh, Janet Hessels-Scheper, Rolf Zijlma, Hendrikus H. Boersma, Annelies Jorritsma-Smit, Geke A. P. Hospers, Elisabeth G. E. de Vries, Marjolijn N. Lub-de Hooge, Erik F. J. de Vries
Pubblicato in: EJNMMI Radiopharmacy and Chemistry, Numero 4/1, 2019, ISSN 2365-421X
Editore: Springer Nature
DOI: 10.1186/s41181-019-0062-7

Direct comparison of the in vitro and in vivo stability of DFO, DFO* and DFOcyclo* for 89Zr-immunoPET

Autori: René Raavé, Gerwin Sandker, Pierre Adumeau, Christian Borch Jacobsen, Floriane Mangin, Michel Meyer, Mathieu Moreau, Claire Bernhard, Laurène Da Costa, Adrien Dubois, Victor Goncalves, Magnus Gustafsson, Mark Rijpkema, Otto Boerman, Jean-Claude Chambron, Sandra Heskamp, Franck Denat
Pubblicato in: European Journal of Nuclear Medicine and Molecular Imaging, Numero 46/9, 2019, Pagina/e 1966-1977, ISSN 1619-7070
Editore: Springer Verlag
DOI: 10.1007/s00259-019-04343-2

Experimental and quantitative imaging techniques in interstitial lung disease

Autori: Nicholas D Weatherley, James A Eaden, Neil J Stewart, Brian J Bartholmai, Andrew J Swift, Stephen Mark Bianchi, Jim M Wild
Pubblicato in: Thorax, Numero 74/6, 2019, Pagina/e 611-619, ISSN 0040-6376
Editore: BMJ Publishing Group
DOI: 10.1136/thoraxjnl-2018-211779

Repeatability and reproducibility of longitudinal relaxation rate in 12 small-animal MRI systems

Autori: John C. Waterton, Catherine D.G. Hines, Paul D. Hockings, Iina Laitinen, Sabina Ziemian, Simon Campbell, Michael Gottschalk, Claudia Green, Michael Haase, Katja Hassemer, Hans-Paul Juretschke, Sascha Koehler, William Lloyd, Yanping Luo, Irma Mahmutovic Persson, James P.B. O'Connor, Lars E. Olsson, Kashmira Pindoria, Jurgen E. Schneider, Steven Sourbron, Denise Steinmann, Klaus Strobel, Sirisha Tad
Pubblicato in: Magnetic Resonance Imaging, Numero 59, 2019, Pagina/e 121-129, ISSN 0730-725X
Editore: Elsevier BV
DOI: 10.1016/j.mri.2019.03.008

Feasibility of PET/CT system performance harmonisation for quantitative multicentre 89Zr studies

Autori: Andres Kaalep, Marc Huisman, Terez Sera, Danielle Vugts, Ronald Boellaard
Pubblicato in: EJNMMI Physics, Numero 5/1, 2018, ISSN 2197-7364
Editore: Springer Nature
DOI: 10.1186/s40658-018-0226-7

How consistently do physicians diagnose and manage drug-induced interstitial lung disease? Two surveys of European ILD specialist physicians

Autori: James A. Eaden, Sarah Skeoch, John C. Waterton, Nazia Chaudhuri, Stephen M. Bianchi
Pubblicato in: ERJ Open Research, Numero 6/1, 2020, Pagina/e 00286-2019, ISSN 2312-0541
Editore: European Respiratory Society
DOI: 10.1183/23120541.00286-2019

New long-acting 89Zr-DFO GLP-1 PET tracers with increased molar activity

Autori: Jonas Wilbs*, René Raavé, Milou Boswinkel, Tine Glendorf, David Rodríguez, Eduardo Felipe Alves Fernandes, Sandra Heskamp, Inga Bjørnsdottir, and Magnus B. F. Gustafsson
Pubblicato in: J. Med. Chem., 2023, ISSN 0022-2623
Editore: American Chemical Society
DOI: 10.1021/acs.jmedchem.2c02073

Utilizing MRI, [18F]FDG-PET and [89Zr]Zr-DFO-28H1 FAP-PET tracer to assess inflammation and fibrogenesis in a reproducible lung injury rat model: a multimodal imaging study

Autori: Milou Boswinkel, René Raavé, Andor Veltien, Tom WJ Scheenen, Nina Fransén Petterson, René in ‘t Zandt, Lars E. Olsson, Karin von Wachenfeldt, Sandra Heskamp, Irma Mahmutovic Persson
Pubblicato in: Frontiers in Nuclear Medicine, Numero 3, 2024, ISSN 2673-8880
Editore: Frontiers media
DOI: 10.3389/fnume.2023.1306251

Imaging human lung perfusion with contrast media: A meta-analysis

Autori: Lucy Edwards, John C Waterton, Josephine Naish, Christopher Short, Thomas Semple, Geoff JM Parker, Marta Tibiletti
Pubblicato in: European Journal of Radiology, 2023, ISSN 0720-048X
Editore: Elsevier BV
DOI: 10.1016/j.ejrad.2023.110850

Bias, Repeatability and Reproducibility of Liver T1 Mapping With Variable Flip Angles

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Imaging Biomarkers (IBs) for Safer Drugs: Validation of Translational Imaging Methods in Drug Safety Assessment - Sofia ref.: 116106

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