Rezultaty
Migration
Manuscript on novel 89Zr-GLP-1 peptide conjugationAn ARRIVE-compliant manuscript submitted for open-access publication describing the design and synthesis the GLP-1 site-specifically conjugated to the optimised 89Zr chelate, the design and synthesis the GLP-1 site-specifically conjugated to IRDye 800CW, molecular integrity and stability of GLP-1 conjugates analytically verified through LC-MS, in vitro evaluation of properties of 89Zr-labelled GLP-1 conjugate: chemical purity, stability, degradation, suitability for in vivo administration, in vivo evaluation of properties of 89Zr-labelled GLP-1 conjugate and IRDye 800CW GLP-1 conjugate Responsible for coordinating and assembling entire manuscript: DijonVerification: (1) PDF of manuscript; (2) Email from journal acknowledging receipt of manuscript; (3) Minutes of WP4 meeting prospectively justifying sample size for animal experiments; (4) A copy of the page on the TRISTAN data inventory (5.0.D1) which shows a record for the data acquired in order to generate this deliverable; (5) url of the site (5.0.D4) containing any SOPs and any exemplar data-sets associated with this deliverable.Responsible for mouse imaging: NijmegenResponsible for analytic verification: NijmegenGNG 4.1.G4: Thermodynamic and kinetic stability of 89Zr in these novel chelates in blood (in vitro) as well as physicochemical properties of labeled compounds should jusify further animal experiments Site-specific conjugated 89Zr-conjugated GLP-1 and the fluorescent analogue, in vitro are impressive enough to justify further animal experimentsVerification: Minutes of WP4 meetingConsequence: If conjugate is unimpressive, previously existing Zr chelates will be used for further studiesDate: M18
Manuscript on chronic bleomycin MR&PETAn ARRIVE-compliant manuscript submitted for open-access publication which (a) characterizes the progression of bleomycin-induced lung inflammation and fibrosis in rats using suitable imaging biomarkers employing 1H-MRI and PET/CT using tracers for inflammation (e.g. FDG), and for structural change (e.g. collagen 1) (b) correlates imaging biomarkers with conventional evaluation such as histology, cells, and protein expression; If the studies are negative, report of the negative findings.Responsible: Lund/TrulyVerification: (1) Minutes of WP3 meeting (2) Pdf of manuscript; (3) Email from journal acknowledging receipt of manuscriptDate: M42GNG 3.3.G1 GO: PET/CT or MRI biomarkers improve the characterization of progression in rats of bleomycin-induced lung inflammation vs fibrosis. Verification: Minutes of WP3 Date: M24Consequence: If the imaging biomarkers are uninformative, NO-GO for multisite preclinical evaluation
manuscript on food effects on BSEP function in patientsA manuscript submitted for open-access publication describing food effects in healthy volunteers on the basal activity of BSEP. This deliverable is conditional and subject to Pfizer internal approval as well as to approval by the EMAResponsible: PfizerVerification: (1) pdf of manuscript; (2) email from journal acknowledging receipt of submitted manuscript; (3) prospective study protocol and sample size (power) calculation appended to WP2 minutes; (4) clinical trial identification number from a recognised clinical trial registry such as clinicaltrials.gov; (5) A copy of the page on the TRISTAN data inventory (5.0.D1) which shows a record for the data acquired in order to generate this deliverable; (6) url of the site (5.0.D4) containing any SOPs and any exemplar data-sets associated with this deliverable ; (7) the data sharing statement..
Review 1 for liver transporter assessment by imagingMigration
Manuscript on use of 89Zr pembrolizumab in NHPsAn ARRIVE-compliant manuscript submitted for open-access publication describing 89Zr-pembrolizuab in NHPResponsible: MSDVerification: (1) Minutes of WP4 meeting including prospective sample size calculation and prospective protocol; (2) Opinion of TRISTAN’s independent Ethics Advisory Board that use of NHP is justified in the context of the entire project goals; (3) PDF of manuscript; (4) Email from journal acknowledging receipt of manuscript; (4) A copy of the page on the TRISTAN data inventory (5.0.D1) which shows a record for the data acquired in order to generate this deliverable; (5) url of the site (5.0.D4) containing any SOPs and any exemplar data-sets associated with this deliverable.GNG 4.3.G3: In vivo experiments in NHP justify a clinical studyVerification: Minutes of WP4 meetingConsequence: Non-human primate study will not be performedDate: M29
Manuscript on physician approaches to DIILDA survey of physician approaches to treatment of DIILD from drugs with known DIILD risk, submitted for open-access publication Responsible for coordinating and assembling entire manuscript: SheffieldResponsible for contributing Sheffield, Bioxydyn, Manchester, Verification: (1) Pdf of manuscript; (2) Email from journal acknowledging receipt of manuscript
Manuscript on imaging cellular vs non-cellular componentsAn ARRIVE-compliant manuscript submitted for open-access publication whichcharacterizes the set-up and characterization of cellular vs. non-cellular components of chronic bleomycin-induced lung fibrosis in rats using (a) suitable 1H-MRI and/or PET imaging biomarkers and (b) discusses implications for clinical assessment, (c) correlates imaging biomarkers with conventional evaluation such as histology, cells, protein expression and ‘lung function’. Reports to include also negative findings.Responsible for coordinating and assembling entire manuscript: Lund/TrulyVerification: (1) Minutes of WP3 meeting including prospective sample size calculation and prospective protocol; (2) Pdf of manuscript; (3) Email from journal acknowledging receipt of manuscriptGNG 3.3 G2: GO: Novel chronic bleomycin model improves the translatability of animal model to clinical setting. Imaging biomarkers suing MRI and/or PET/CT improve characterization of cellular vs. non-cellular components of bleomycin-induced lung fibrosis in a chronic rat model. Verification: (1) Minutes of WP3 meeting Consequence: If the imaging biomarkers are uninformative: NO-GO for multisite preclinical evaluation; NO-GO for progression into manDate: M36
Manuscript on novel 89Zr chelates for protein labelingMigration
Manuscript on the progression of bleomycin induced inflammation and fibrosis in rats imaged by MRI/CTMigration
Manuscript on simplified IL2 labeling methodA manuscript submitted for open-access publication describing a simplified method that could be applied in multicentre studies to produce a 68Ga or 18F-labelled IL2-based PET tracer.Responsible for coordinating and assembling entire manuscript: NijmegenResponsible for contributing: GroningenVerification: (1) PDF of manuscript; (2) Email from journal acknowledging receipt of manuscript; (3) A copy of the page on the TRISTAN data inventory (5.0.D1) which shows a record for the data acquired in order to generate this deliverable; (4) url of the site (5.0.D4) containing any SOPs and any exemplar data-sets associated with this deliverable.GNG 4.3.G1: a simplified method that could be applied in multicentre studies to produce a 68Ga or 18F-labelled IL2-based PET tracerVerification: Minutes of WP4 meetingConsequence: IL2 tracer will not be used in 4.3.D2Date: M18
Manuscript for gadoxetate relaxivitiesA manuscript submitted for open-access publication reporting the different relaxivities of gadoxetate between extra- and intracellular space characterised by in vitro studies at relevant field strengths. May be either a stand-alone manuscript or alternatively included as a section or supplementary material in a broader manuscript.Responsible for coordinating work assembling entire manuscript: Bayer Responsible for contributing data: Bayer, MSD, SanofiVerification: (1) pdf of manuscript; (2) email from journal acknowledging receipt of submitted manuscript; (3) A copy of the page on the TRISTAN data inventory (5.0.D1) which shows a record for the data acquired in order to generate this deliverable.
Workplan for pre-clinical BSEP-probe evaluationMigration
Manuscript for phantom imaging reproducibilityMigration
Manuscript for reviews on ILD imaging in humansMigration
Migration
Phantom QC for clinical MRI scanner stability over timeMigration
Gadoxetate imaging model softwareMigration
Open-access website for validation SOP downloadMigration
Free-breathing 3D acquisition protocol for clinical MRIMigration
optimized data acquisition of 129 Xe MRIMigration
Free-breathing 3D acquisition protocol for pre-clinical MRIMigration
Publikacje
Autorzy:
Irma Mahmutovic Persson, Hanna Falk Håkansson, Anders Örbom, Jian Liu, Karin von Wachenfeldt, Lars E. Olsson
Opublikowane w:
Frontiers in Physiology, Numer 11, 2020, ISSN 1664-042X
Wydawca:
Frontiers Research Foundation
DOI:
10.3389/fphys.2020.00584
Autorzy:
Eduardo Felipe Alves Fernandes,*,‡ Jonas Wilbs,*,‡ Rene Raavé, Christian Borch Jacobsen,
Hanne Toftelund, Hans Helleberg, Milou Boswinkel, Sandra Heskamp,
Magnus Bernt Frederik Gustafsson, and Inga Bjørnsdottir
Opublikowane w:
ACS Pharmacol. Transl. Sci., 2022, ISSN 2575-9108
Wydawca:
American Chemical Society
DOI:
10.1021/acsptsci.2c00075
Autorzy:
John Charles Waterton
Opublikowane w:
Magnetic Resonance Materials in Physics, Biology and Medicine, Numer 34(6), 2021, ISSN 2213-7793
Wydawca:
Springer
DOI:
10.1007/s10334-021-00928-x
Autorzy:
Elly L. van der Veen, Frans V. Suurs, Frederik Cleeren, Guy Bormans, Philip H. Elsinga, Geke A.P. Hospers, Marjolijn N. Lub-de Hooge, Elisabeth G.E. de Vries, Erik F.J. de Vries, Inês F. Antunes
Opublikowane w:
Journal of Nuclear Medicine, Numer 61/9, 2020, Strona(/y) 1355-1360, ISSN 0161-5505
Wydawca:
Kexue Chubaneshe/Science Press
DOI:
10.2967/jnumed.119.238782
Autorzy:
van Sluis J, Noordzij W, de Vries EGE, Kok IC, de Groot DJA, Jalving M, Lub-de Hooge MN, Brouwers AH, Boellaard R
Opublikowane w:
Mol Imaging Biol., 2023, ISSN 2193-1801
Wydawca:
Springer Science and Business Media Deutschland GmbH
DOI:
10.1007/s11307-022-01775-5
Autorzy:
Tibiletti M, Eaden JA, Naish JH, Hughes PJC, Waterton JC, Heaton MJ, Chaudhuri N, Skeoch S, Bruce IN, Bianchi S, Wild JM, Parker GJM.
Opublikowane w:
Magnetic Resonance Imaging, 2023, ISSN 0346-251X
Wydawca:
Pergamon Press Ltd.
DOI:
10.1016/j.mri.2022.10.005
Autorzy:
Daniel Scotcher, Nicola Melillo, Sirisha Tadimalla, Adam S. Darwich, Sabina Ziemian, Kayode Ogungbenro, Gunnar Schütz, Steven Sourbron, and Aleksandra Galetin
Opublikowane w:
Mol. Pharmaceutics, Numer 18, 8, 2021, ISSN 1543-8384
Wydawca:
American Chemical Society
DOI:
10.1021/acs.molpharmaceut.1c00206
Autorzy:
Pierre Adumeau, René Raavé, Milou Boswinkel, Sandra Heskamp, Hans J. C. T. Wessels, Alain J. van Gool, Mathieu Moreau, Claire Bernhard, Laurène Da Costa, Victor Goncalves, and Franck Denat
Opublikowane w:
Bioconjugate Chem., 2022, ISSN 1520-4812
Wydawca:
American Chemical Society
DOI:
10.1021/acs.bioconjchem.2c00049
Autorzy:
I. C. Kok, J. S. Hooiveld, P. P. van de Donk1y, D. Giesen1, E. L. van der Veen, M. N. Lub-de Hooge2, A. H. Brouwers,
T. J. N. Hiltermann, A. J. van der Wekken4, L. B. M. Hijmering-Kappelle, W. Timens, S. G. Elias, G. A. P. Hospers,
H. J. M. Groen, W. Uyterlinde, B. van der Hiel8, J. B. Haanen, D. J. A. de Groot, M. Jalving & E. G. E. de Vries
Opublikowane w:
Annals of Oncology, Numer VOLUME 33, ISSUE 1, P80-88, 2021, ISSN 0923-7534
Wydawca:
Oxford University Press
DOI:
10.1016/j.annonc.2021.10.213
Autorzy:
Joshua R. Astley BEng, Alberto M. Biancardi PhD, Helen Marshall PhD, Paul J. C. Hughes PhD, Guilhem J. Collier PhD, Laurie J. Smith PhD, James A. Eaden PhD, Rod Hughes MD, Jim M. Wild PhD, Bilal A. Tahir PhD
Opublikowane w:
JMRI, 2023, ISSN 1053-1807
Wydawca:
John Wiley & Sons Inc.
DOI:
10.1002/jmri.28519
Autorzy:
Melillo N, Scotcher D, Kenna JG, Green C, Hines CDG, Laitinen I, Hockings PD, Ogungbenro K, Gunwhy ER, Sourbron S, Waterton JC, Schuetz G, Galetin A.
Opublikowane w:
Pharmaceutics, Numer 2023 Mar 10;15(3), 2023, Strona(/y) 896, ISSN 1999-4923
Wydawca:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/pharmaceutics15030896
Autorzy:
Astley JR, Biancardi AM, Hughes PJC, Marshall H, Collier GJ, Chan HF, Saunders LC, Smith LJ, Brook ML, Thompson R, Rowland-Jones S, Skeoch S, Bianchi SM, Hatton MQ, Rahman NM, Ho LP, Brightling CE, Wain LV, Singapuri A, Evans RA, Moss AJ, McCann GP, Neubauer S, Raman B; C-MORE/PHOSP-COVID Collaborative Group;Wild JM, Tahir BA.
Opublikowane w:
J Magn Reson Imaging, 2023, ISSN 1053-1807
Wydawca:
John Wiley & Sons Inc.
DOI:
10.1002/jmri.28643
Autorzy:
Sabina Ziemian, Claudia Green, Steven Sourbron, Gregor Jost, Gunnar Schütz, Catherine D.G. Hines
Opublikowane w:
NMR in Biomedicine, Numer 34/1, 2021, ISSN 0952-3480
Wydawca:
John Wiley & Sons Inc.
DOI:
10.1002/nbm.4401
Autorzy:
Irma Mahmutovic Persson, Karin von Wachenfeldt, John C. Waterton, Lars E. Olsson
Opublikowane w:
J. Clin. Med., Numer 10(1), 107, 2021, ISSN 2077-0383
Wydawca:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/jcm10010107
Autorzy:
Irma Mahmutovic Persson, Nina Fransén Pettersson, Jian Liu, Hanna Falk Håkansson, Anders Örbom, René In ’t Zandt, Ritha Gidlöf, Marie Sydoff, Karin von Wachenfeldt, Lars E. Olsson
Opublikowane w:
Journal of Clinical Medicine, Numer 9/11, 2020, Strona(/y) 3706, ISSN 2077-0383
Wydawca:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/jcm9113706
Autorzy:
Wenping Li, Yuchuan Wang, Daniel Rubins, Idriss Bennacef, Marie Holahan, Hyking Haley, Mona Purcell, Liza Gantert, SuChun Hseih, Michael Judo, Wolfgang Seghezzi, Shuli Zhang, Elly L. van der Veen, Marjolijn N. Lub-de Hooge, Elisabeth G.E. de Vries, Jeffrey L. Evelhoch, Michael Klimas, Eric D. Hostetler
Opublikowane w:
Molecular Imaging and Biology, Numer 23/2, 2021, Strona(/y) 250-259, ISSN 1536-1632
Wydawca:
Elsevier BV
DOI:
10.1007/s11307-020-01558-w
Autorzy:
Sandra Heskamp, René Raavé, Otto Boerman, Mark Rijpkema, Victor Goncalves, Franck Denat
Opublikowane w:
Bioconjugate Chemistry, Numer 28/9, 2017, Strona(/y) 2211-2223, ISSN 1043-1802
Wydawca:
American Chemical Society
DOI:
10.1021/acs.bioconjchem.7b00325
Autorzy:
Sarah Skeoch, Nicholas Weatherley, Andrew Swift, Alexander Oldroyd, Christopher Johns, Conal Hayton, Alessandro Giollo, James Wild, John Waterton, Maya Buch, Kim Linton, Ian Bruce, Colm Leonard, Stephen Bianchi, Nazia Chaudhuri
Opublikowane w:
Journal of Clinical Medicine, Numer 7/10, 2018, Strona(/y) 356, ISSN 2077-0383
Wydawca:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/jcm7100356
Autorzy:
Christian Borch Jacobsen, René Raavé, Marie Østergaard Pedersen, Pierre Adumeau, Mathieu Moreau, Ibai E. Valverde, Inga Bjørnsdottir, Jesper Bøggild Kristensen, Mette Finderup Grove, Kirsten Raun, James McGuire, Victor Goncalves, Sandra Heskamp, Franck Denat, Magnus Gustafsson
Opublikowane w:
Nuclear Medicine and Biology, Numer 82-83, 2020, Strona(/y) 49-56, ISSN 0969-8051
Wydawca:
Elsevier BV
DOI:
10.1016/j.nucmedbio.2019.11.006
Autorzy:
Peter Wierstra, Gerwin Sandker, Erik Aarntzen, Martin Gotthardt, Gosse Adema, Johan Bussink, René Raavé, Sandra Heskamp
Opublikowane w:
EJNMMI Radiopharmacy and Chemistry, Numer 4/1, 2019, ISSN 2365-421X
Wydawca:
Springer Nature
DOI:
10.1186/s41181-019-0078-z
Autorzy:
Elly L. van der Veen, Inês F. Antunes, Petra Maarsingh, Janet Hessels-Scheper, Rolf Zijlma, Hendrikus H. Boersma, Annelies Jorritsma-Smit, Geke A. P. Hospers, Elisabeth G. E. de Vries, Marjolijn N. Lub-de Hooge, Erik F. J. de Vries
Opublikowane w:
EJNMMI Radiopharmacy and Chemistry, Numer 4/1, 2019, ISSN 2365-421X
Wydawca:
Springer Nature
DOI:
10.1186/s41181-019-0062-7
Autorzy:
René Raavé, Gerwin Sandker, Pierre Adumeau, Christian Borch Jacobsen, Floriane Mangin, Michel Meyer, Mathieu Moreau, Claire Bernhard, Laurène Da Costa, Adrien Dubois, Victor Goncalves, Magnus Gustafsson, Mark Rijpkema, Otto Boerman, Jean-Claude Chambron, Sandra Heskamp, Franck Denat
Opublikowane w:
European Journal of Nuclear Medicine and Molecular Imaging, Numer 46/9, 2019, Strona(/y) 1966-1977, ISSN 1619-7070
Wydawca:
Springer Verlag
DOI:
10.1007/s00259-019-04343-2
Autorzy:
Nicholas D Weatherley, James A Eaden, Neil J Stewart, Brian J Bartholmai, Andrew J Swift, Stephen Mark Bianchi, Jim M Wild
Opublikowane w:
Thorax, Numer 74/6, 2019, Strona(/y) 611-619, ISSN 0040-6376
Wydawca:
BMJ Publishing Group
DOI:
10.1136/thoraxjnl-2018-211779
Autorzy:
John C. Waterton, Catherine D.G. Hines, Paul D. Hockings, Iina Laitinen, Sabina Ziemian, Simon Campbell, Michael Gottschalk, Claudia Green, Michael Haase, Katja Hassemer, Hans-Paul Juretschke, Sascha Koehler, William Lloyd, Yanping Luo, Irma Mahmutovic Persson, James P.B. O'Connor, Lars E. Olsson, Kashmira Pindoria, Jurgen E. Schneider, Steven Sourbron, Denise Steinmann, Klaus Strobel, Sirisha Tad
Opublikowane w:
Magnetic Resonance Imaging, Numer 59, 2019, Strona(/y) 121-129, ISSN 0730-725X
Wydawca:
Elsevier BV
DOI:
10.1016/j.mri.2019.03.008
Autorzy:
Andres Kaalep, Marc Huisman, Terez Sera, Danielle Vugts, Ronald Boellaard
Opublikowane w:
EJNMMI Physics, Numer 5/1, 2018, ISSN 2197-7364
Wydawca:
Springer Nature
DOI:
10.1186/s40658-018-0226-7
Autorzy:
James A. Eaden, Sarah Skeoch, John C. Waterton, Nazia Chaudhuri, Stephen M. Bianchi
Opublikowane w:
ERJ Open Research, Numer 6/1, 2020, Strona(/y) 00286-2019, ISSN 2312-0541
Wydawca:
European Respiratory Society
DOI:
10.1183/23120541.00286-2019
Autorzy:
Jonas Wilbs*, René Raavé, Milou Boswinkel, Tine Glendorf, David Rodríguez, Eduardo Felipe Alves Fernandes, Sandra Heskamp, Inga Bjørnsdottir, and Magnus B. F. Gustafsson
Opublikowane w:
J. Med. Chem., 2023, ISSN 0022-2623
Wydawca:
American Chemical Society
DOI:
10.1021/acs.jmedchem.2c02073
Autorzy:
Lucy Edwards, John C Waterton, Josephine Naish, Christopher Short, Thomas Semple, Geoff JM Parker, Marta Tibiletti
Opublikowane w:
European Journal of Radiology, 2023, ISSN 0720-048X
Wydawca:
Elsevier BV
DOI:
10.1016/j.ejrad.2023.110850
Autorzy:
Sirisha Tadimalla PhD,Daniel J. Wilson PhD,David Shelley BSc,Gavin Bainbridge BSc,Margaret Saysell BSc,Iosif A. Mendichovszky MD,Martin J. Graves PhD,J. Ashley Guthrie MB,John C. Waterton PhD,Geoffrey J.M. Parker PhD,Steven P. Sourbron
Opublikowane w:
Journal of Magnetic Resonance Imaging, 2022, ISSN 1053-1807
Wydawca:
John Wiley & Sons Inc.
DOI:
10.1002/jmri.28127
Autorzy:
Minjun Chen, Yvonne Will
Opublikowane w:
Methods in Pharmacology and Toxicology, 2018, ISBN 978-1-4939-7677-5
Wydawca:
Springer New York
DOI:
10.1007/978-1-4939-7677-5
Autorzy:
J. Gerry Kenna, John C. Waterton, Andreas Baudy, Aleksandra Galetin, Catherine D. G. Hines, Paul Hockings, Manishkumar Patel, Daniel Scotcher, Steven Sourbron, Sabina Ziemian, Gunnar Schuetz
Opublikowane w:
Drug-Induced Liver Toxicity, 2018, Strona(/y) 627-651, ISBN 978-1-4939-7676-8
Wydawca:
Springer New York
DOI:
10.1007/978-1-4939-7677-5_30
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