Objective
Proteases are key molecules in biological systems. They modify numerous proteins by hydrolytic cleavage, thus controlling and executing many physiological processes. Their intricate networks require a tight regulation to prevent fortuitous proteolysis. Where this regulation fails, proteases trigger pathologies such as neurodegeneration, inflammation, and cancer. Many therapeutic approaches are directed towards proteases or their natural inhibitors, already leading to drugs against life threatening diseases.
The tight regulation of proteases by posttranslational modifications makes current functional genomics technologies unsuitable to fully establish biological relevance. CAMP will lay the groundwork to study and understand proteases through activity labeling and functional imaging in cells. Specifically, we will investigate the substrate specificity of proteases using large peptide libraries, derive fluorescent labeling molecules from the sequence information gathered, and use these molecules to investigate proteolytic activities in cellular environments. A set of 45 proteases covering four prototypic protease subfamilies has been selected taking into account scientific relevance, structural diversity, and potential socio-economic interest.
Given the estimated number of 600 to 1100 proteases in the human genome, our selected set constitutes a significant representation and will establish the feasibility of our approach to address the protease proteome. CAMP's proteases will serve as prototypes to develop novel protease-specific technologies and probes for studying expression and folding, the activity state of proteases and their endogenous interaction partners in vitro and in vivo. The gathered information will be annotated in a public repository. We expect that the derived insights will foster high-throughput approaches and research, leading to new avenues in drug discovery using integrated data on the protease proteome.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- medical and health sciences clinical medicine oncology
- medical and health sciences basic medicine pathology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-LIFESCIHEALTH-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
BELLATERRA (CERDANYOLA DEL VALLÈS )
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.