Obiettivo This project will study 5 special populations throughout Europe which represent a unique resource for genomic research. It will quantify genetic variation in genes known to be involved in health and disease and will harness this variation to identify novel variants. The project will build on the achievements of substantial existing investment in these special populations and will pool expertise across Europe in phenotyping, genotyping, statistical genetics and social and ethical aspects of genomic research. A common database of health and disease-related phenotypes will be established and cores of expertise established in the major project areas.this will create the largest database of phenotypic and genotypic data from genetic isolate populations and thus will improve European competitiveness in gene discovery. The project will also provide the platform for the evaluation of a novel gene discovery approach (hybrid identity profiling) which has been developed by a European SME.Study objectives include:To describe the variation in allele frequencies in genetic variants involved in health or disease states;To harmonise existing health and disease-related phenotype data and reach agreement on genotyping procedures; To adopt standard definitions, measurement methods and common data storage formats to form a common study database. To evaluate a novel European technology developed by IntegraGen (SME) for discovery of novel genetic variants;To undertake an extended pedigree based genome-wide linkage analysis to identify quantitative trait loci (QTL) underlying a large number of traits which underlie many of the main diseases of public health importance in Europe. Cross population mapping methods will be employed in fine mapping;To develop new statistical methods for pedigree based linkage analysis in these special populations;To define a best approach for dealing with related ethical and social issues in these populations. Campo scientifico natural sciencesbiological sciencesgeneticsnatural sciencescomputer and information sciencessoftwaremedical and health scienceshealth sciencespublic healthnatural sciencescomputer and information sciencesdatabasessocial sciencessociologysocial issues Programma(i) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Argomento(i) LSH-2003-1.1.0-1 - Topics for Specific Targeted Research Project in the area of Fundamental knowledge and basic tools for functional genomics in all organisms Invito a presentare proposte FP6-2004-LIFESCIHEALTH-5 Vedi altri progetti per questo bando Meccanismo di finanziamento STREP - Specific Targeted Research Project Coordinatore THE UNIVERSITY OF EDINBURGH Contributo UE Nessun dato Indirizzo Old College, South Bridge EDINBURGH Regno Unito Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato Partecipanti (7) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto MEDICAL RESARCH COUNCIL Regno Unito Contributo UE Nessun dato Indirizzo 20 Park Crescent n/a LONDON Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato ERASMUS MEDICAL CENTER, ROTTERDAM Paesi Bassi Contributo UE Nessun dato Indirizzo Dr Molewaterplein 50 1738 ROTTERDAM Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato UNIVERSITY OF UPPSALA, Svezia Contributo UE Nessun dato Indirizzo St Olobsgatan 10B 256 UPPSALA Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato GSF - FORSCHUNGSZENTRUM FÜR UMWELT UND GESUNDHEIT, GMBH Germania Contributo UE Nessun dato Indirizzo Ingolstaedter Landstr. 1 1129 MUNCHEN-NEUHERBERG Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato SVEUCILISTE U ZABREBU, MEDICINSKI FACULTET Croazia Contributo UE Nessun dato Indirizzo Salata 3/B n/a ZAGREB Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato INTEGRAGEN SA Francia Contributo UE Nessun dato Indirizzo 4, rue Pierre Fontaine EVRY Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato ACCADEMIA EUROPEA BOLZANO Italia Contributo UE Nessun dato Indirizzo Drususallee 1 n/a BOLZANO Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato