Cel This project will study 5 special populations throughout Europe which represent a unique resource for genomic research. It will quantify genetic variation in genes known to be involved in health and disease and will harness this variation to identify novel variants. The project will build on the achievements of substantial existing investment in these special populations and will pool expertise across Europe in phenotyping, genotyping, statistical genetics and social and ethical aspects of genomic research. A common database of health and disease-related phenotypes will be established and cores of expertise established in the major project areas.this will create the largest database of phenotypic and genotypic data from genetic isolate populations and thus will improve European competitiveness in gene discovery. The project will also provide the platform for the evaluation of a novel gene discovery approach (hybrid identity profiling) which has been developed by a European SME.Study objectives include:To describe the variation in allele frequencies in genetic variants involved in health or disease states;To harmonise existing health and disease-related phenotype data and reach agreement on genotyping procedures; To adopt standard definitions, measurement methods and common data storage formats to form a common study database. To evaluate a novel European technology developed by IntegraGen (SME) for discovery of novel genetic variants;To undertake an extended pedigree based genome-wide linkage analysis to identify quantitative trait loci (QTL) underlying a large number of traits which underlie many of the main diseases of public health importance in Europe. Cross population mapping methods will be employed in fine mapping;To develop new statistical methods for pedigree based linkage analysis in these special populations;To define a best approach for dealing with related ethical and social issues in these populations. Dziedzina nauki natural sciencesbiological sciencesgeneticsnatural sciencescomputer and information sciencessoftwaremedical and health scienceshealth sciencespublic healthnatural sciencescomputer and information sciencesdatabasessocial sciencessociologysocial issues Program(-y) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Temat(-y) LSH-2003-1.1.0-1 - Topics for Specific Targeted Research Project in the area of Fundamental knowledge and basic tools for functional genomics in all organisms Zaproszenie do składania wniosków FP6-2004-LIFESCIHEALTH-5 Zobacz inne projekty w ramach tego zaproszenia System finansowania STREP - Specific Targeted Research Project Koordynator THE UNIVERSITY OF EDINBURGH Wkład UE Brak danych Adres Old College, South Bridge EDINBURGH Zjednoczone Królestwo Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych Uczestnicy (7) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko MEDICAL RESARCH COUNCIL Zjednoczone Królestwo Wkład UE Brak danych Adres 20 Park Crescent n/a LONDON Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych ERASMUS MEDICAL CENTER, ROTTERDAM Niderlandy Wkład UE Brak danych Adres Dr Molewaterplein 50 1738 ROTTERDAM Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych UNIVERSITY OF UPPSALA, Szwecja Wkład UE Brak danych Adres St Olobsgatan 10B 256 UPPSALA Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych GSF - FORSCHUNGSZENTRUM FÜR UMWELT UND GESUNDHEIT, GMBH Niemcy Wkład UE Brak danych Adres Ingolstaedter Landstr. 1 1129 MUNCHEN-NEUHERBERG Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych SVEUCILISTE U ZABREBU, MEDICINSKI FACULTET Chorwacja Wkład UE Brak danych Adres Salata 3/B n/a ZAGREB Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych INTEGRAGEN SA Francja Wkład UE Brak danych Adres 4, rue Pierre Fontaine EVRY Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych ACCADEMIA EUROPEA BOLZANO Włochy Wkład UE Brak danych Adres Drususallee 1 n/a BOLZANO Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych