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BraiN20®: A paradigm shift in Acute Ischemic Stroke (AIS) patient management

Project description

Real-time brain monitoring offers hope for stroke care

Acute ischaemic stroke (AIS) is the second leading cause of death and disability worldwide. The current gold standard, endovascular treatment (EVT), has limited efficacy at 46 % due to the lack of tools for precise decision-making. With this in mind, the EIC-funded promise project aims to reverse this trend and change the face of stroke care. It will introduce a cutting-edge non-invasive medical device that offers real-time monitoring of AIS patients’ brain viability. By analysing the neurophysiological biomarker N20, a surrogate of cerebral blood flow, BraiN20® accurately predicts which patients will benefit most from EVT. The project will conduct clinical trials, obtain CE Mark and FDA clearance, and ultimately bring the device to the market. The overall aim is to significantly improve patient outcomes.

Objective

Acute Ischemic Stroke (AIS) represents 85% of strokes and is the 2nd leading cause of death and the leading cause of disability worldwide. Today, AIS patient management lies on imaging tools (multimodal CT/MRI) and scores to select patients for Endovascular treatment (EVT) the gold standard. Still, its efficacy is limited to 46% due to the lack of tools to guide decision-making. BraiN20 is a non-invasive medical device class IIb that provides real-time monitoring of AIS patients brain viability, thereby predicting who will benefit from EVT. Time is Brain has the exclusive right to the IPR of a neurophysiological biomarker: N20, a SEP and surrogate of cerebral blood flow. TiB aims to implement the clinical trials to validate BraiN20, acquire CE-Mark and FDA clearance, and bring it to market. By providing real-time and continuous monitoring of brain viability, BraiN20 will accelerate stroke management and predict EVT outcome and offer tailored care for each patient.

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Keywords

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Programme(s)

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Topic(s)

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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

HORIZON-EIC-ACC-BF - HORIZON EIC Accelerator Blended Finance

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Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) HORIZON-EIC-2022-ACCELERATOR-01

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Coordinator

TIME IS BRAIN SL
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 2 500 000,00
Address
CARRETERA CANYET S/N
08916 Badalona
Spain

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Este Cataluña Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Links
Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 5 150 878,25
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