Objective The FAST project aims at the development of safe and effective treatment of food allergies. It targets persistent and severe allergy to fish and fruit. Besides persistence and severity, this choice is based on prevalence and the importance of these foods for a healthy diet. Classical allergen-specific immunotherapy (SIT) for treatment of food allergy using subcutaneous injections with food extracts has proven to be effective but too dangerous due to anaphylactic side-effects. FAST will therefore develop a safe alternative by replacing food extracts with hypo-allergenic recombinant major allergens, the active ingredients of SIT. Both severe fish and fruit allergy are caused by a single major allergen, parvalbumin for fish and lipid transfer protein for fruit. This makes development of a novel biotechnological product feasible. Two approaches will be evaluated for achieving hypoallergenicity, i.e. site-directed mutagenesis and chemical modification. The most promising hypo-allergenic versions of parvalbumin and lipid transfer protein will be produced under GMP conditions. After pre-clinical testing (toxicology testing and efficacy in mouse models), Phase I and II randomized double-blind placebo-controlled multi-center clinical trials will be performed. Two routes of administration will be evaluated, subcutaneous in case of fish and sublingual in case of fruit. The primary read-out will be the double-blind placebo-controlled food challenge. To understand the underlying immune mechanisms of subcutaneous and sublingual immunotherapy, these trials will be accompanied by in depth serological and cellular immune analyses, allowing identification of novel biomarkers for monitoring treatment efficacy. FAST will improve the quality of life of food allergic patients by providing a safe and effective curative treatment that will end their dependence on avoidance and rescue medication. Fields of science medical and health sciencesclinical medicineallergologyfood allergyagricultural sciencesagriculture, forestry, and fisheriesagriculturehorticulturefruit growingnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural sciencesbiological sciencesbiochemistrybiomoleculeslipidsmedical and health sciencesbasic medicineimmunologyimmunotherapy Keywords clinical trials fish food allergy fruit hypo-allergens immunotherapy recombinant allergens Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2007-1.4-3 - Immunotherapy of human food allergies Call for proposal FP7-HEALTH-2007-A See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM Address Meibergdreef 15 1105AZ Amsterdam Netherlands See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Higher or Secondary Education Establishments Administrative Contact Richard De Loor (Mr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data Participants (18) Sort alphabetically Sort by EU Contribution Expand all Collapse all MEDIZINISCHE UNIVERSITAET WIEN Austria EU contribution € 270 403,50 Address Spitalgasse 23 1090 Wien See on map Region Ostösterreich Wien Wien Activity type Higher or Secondary Education Establishments Administrative Contact Otto Scheiner (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data QUADRAM INSTITUTE BIOSCIENCE United Kingdom EU contribution € 417 654,00 Address Quadram institute bioscience norwich research park NR4 7UQ Norwich See on map Region East of England East Anglia Breckland and South Norfolk Activity type Research Organisations Administrative Contact Mary Anderson (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data SERVICIO MADRILENO DE SALUD Spain EU contribution € 96 214,40 Address Plaza carlos trias bertran 7 28020 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact José Francisco Soto Bonel (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data ODENSE UNIVERSITETSHOSPITAL Denmark EU contribution € 86 132,10 Address Sdr. boulevard 29 5000 Odense See on map Activity type Research Organisations Administrative Contact Peter Frandsen (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data PROVINCIA ITALIANA DELLA CONGREGAZIONE DEI FIGLI DELLA IMMACOLATA CONCEZIONE Participation ended Italy EU contribution € 42 512,28 Address Via della luce 46 00153 Roma See on map Activity type Research Organisations Administrative Contact Adriano Mari (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERSYTET MEDYCZNY W LODZI. Poland EU contribution € 64 013,62 Address Al. kosciuszki, 4 90419 Lodz See on map Region Makroregion centralny Łódzkie Łódzki Activity type Higher or Secondary Education Establishments Administrative Contact Katarzyna Bieniek (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON Greece EU contribution € 168 853,50 Address 6 christou lada str 10561 Athina See on map Region Αττική Aττική Κεντρικός Τομέας Αθηνών Activity type Higher or Secondary Education Establishments Administrative Contact Maria Chatzara (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data LANDSPITALI UNIVERSITY HOSPITAL Iceland EU contribution € 103 392,32 Address Eiriksgata 5 101 Reykjavik See on map Region Ísland Ísland Höfuðborgarsvæði Activity type Higher or Secondary Education Establishments Administrative Contact Eyrun Steinsson (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data HAL ALLERGY BV Netherlands EU contribution € 112 891,55 Address J h oortweg 15 2333 CH Leiden See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Henk Naaktgeboren (Mr.) Links Contact the organisation Opens in new window Other funding No data BIAL INDUSTRIAL FARMACEUTICA S.A. Spain EU contribution € 42 003,93 Address Alameda urquijo 27 48008 Bilbao See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Inigo Pagoaga Izurrategui (Mr.) Links Contact the organisation Opens in new window Other funding No data BIOMAY AG Austria EU contribution € 181 607,62 Address Lazarettgasse 19 1090 Wien See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Angela Neubauer (Dr.) Links Contact the organisation Opens in new window Other funding No data REFLAB APS Participation ended Denmark EU contribution € 7 788,75 Address Tagensvej 20 2200 Koebenhavn See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Eva Valbjorn Sorensen (Prof) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES France EU contribution € 62 461,00 Address Rue leblanc 25 75015 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Eliane Deck-Chaumont (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data REGION HOVEDSTADEN Denmark EU contribution € 345 352,08 Address Kongens vaenge 2 3400 Hillerod See on map Region Danmark Hovedstaden Nordsjælland Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Tine Green (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data PARIS-LODRON-UNIVERSITAT SALZBURG Austria EU contribution € 101 215,00 Address Kapitelgasse 4-6 5020 Salzburg See on map Region Westösterreich Salzburg Salzburg und Umgebung Activity type Higher or Secondary Education Establishments Administrative Contact Gabriele Gadermaier (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data SERVICIO ANDALUZ DE SALUD Spain EU contribution € 121 680,00 Address Avenida de la constitucion 18 41071 Sevilla See on map Region Sur Andalucía Sevilla Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Elena Martín Bautista (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERSITAIR MEDISCH CENTRUM UTRECHT Netherlands EU contribution € 63 069,64 Address Heidelberglaan 100 3584 CX Utrecht See on map Region West-Nederland Utrecht Utrecht Activity type Higher or Secondary Education Establishments Administrative Contact Antoinette Van Der Linden (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data CLINICAL TRIAL CENTER MAASTRICHT Netherlands EU contribution € 132 975,00 Address Oxfordlaan 70 6229 EV Maastricht See on map Region Zuid-Nederland Limburg (NL) Zuid-Limburg Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Carl De Bont (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data
