Objectif
The FAST project aims at the development of safe and effective treatment of food allergies. It targets persistent and severe allergy to fish and fruit. Besides persistence and severity, this choice is based on prevalence and the importance of these foods for a healthy diet. Classical allergen-specific immunotherapy (SIT) for treatment of food allergy using subcutaneous injections with food extracts has proven to be effective but too dangerous due to anaphylactic side-effects. FAST will therefore develop a safe alternative by replacing food extracts with hypo-allergenic recombinant major allergens, the active ingredients of SIT. Both severe fish and fruit allergy are caused by a single major allergen, parvalbumin for fish and lipid transfer protein for fruit. This makes development of a novel biotechnological product feasible. Two approaches will be evaluated for achieving hypoallergenicity, i.e. site-directed mutagenesis and chemical modification. The most promising hypo-allergenic versions of parvalbumin and lipid transfer protein will be produced under GMP conditions. After pre-clinical testing (toxicology testing and efficacy in mouse models), Phase I and II randomized double-blind placebo-controlled multi-center clinical trials will be performed. Two routes of administration will be evaluated, subcutaneous in case of fish and sublingual in case of fruit. The primary read-out will be the double-blind placebo-controlled food challenge. To understand the underlying immune mechanisms of subcutaneous and sublingual immunotherapy, these trials will be accompanied by in depth serological and cellular immune analyses, allowing identification of novel biomarkers for monitoring treatment efficacy. FAST will improve the quality of life of food allergic patients by providing a safe and effective curative treatment that will end their dependence on avoidance and rescue medication.
Champ scientifique
- medical and health sciencesclinical medicineallergologyfood allergy
- agricultural sciencesagriculture, forestry, and fisheriesagriculturehorticulturefruit growing
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteins
- natural sciencesbiological sciencesbiochemistrybiomoleculeslipids
- medical and health sciencesbasic medicineimmunologyimmunotherapy
Mots‑clés
Appel à propositions
FP7-HEALTH-2007-A
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Régime de financement
CP-FP - Small or medium-scale focused research projectCoordinateur
1105AZ Amsterdam
Pays-Bas
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Participants (18)
1090 Wien
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NR4 7UQ Norwich
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28046 MADRID
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5000 ODENSE
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Participation terminée
00153 ROMA
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90419 Lodz
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10561 Athina
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101 Reykjavik
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2333 CH LEIDEN
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48008 BILBAO
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1090 WIEN
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Participation terminée
2200 KOEBENHAVN
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75015 PARIS 15
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3400 Hillerod
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5020 Salzburg
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41071 Sevilla
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3584 CX Utrecht
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6229 EV Maastricht
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