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Pathogenesis of Type 1 Diabetes - Testing the Hygiene Hypothesis

Objectif

Preliminary data indicate that there is a strong association between the incidence of immune-mediated diseases and improving standard of living and hygiene. One of the steepest gradient in standard of living worldwide is present at the border between Russian Karelia and Finland with a sevenfold difference in the gross national product, while Estonia represents a country in rapid transition. These three populations comprise a “living laboratory” providing a unique possibility to test the hygiene hypothesis in the development of immune-mediated diseases. The incidence of type 1 diabetes (T1D) is six times lower in Russian Karelia than in Finland, whereas there are very limited differences in the frequency of risk HLA genotypes in the background population. This proposal aims at comparing (i) the frequency of beta-cell autoimmunity and other organ-specific autoantibodies; (ii) the frequency of IgE-specific sensitisation and signs of allergy; (iii) the frequency of various infections; (iv) the gut microbial flora; and (v) dietary intake in young children between the three populations. The birth cohort arm of the study aims at (i) delineating the ontogeny of the immune system by using modern tools of functional genomics; (ii) comparing the functional characteristics of regulatory T cells; (iii) characterising the gut microbial colonisation in infants; (iv) assessing the timing of exposure to foreign proteins in infancy (v) defining the interrelations between dietary factors, gut microbial flora and acute microbial infections. The objectives will be approached by studying 1600 children at the age of 3 and 5 years and by observing a birth cohort comprising about 320 subjects with HLA-conferred susceptibility to autoimmunity from birth up to the age of 3 years in each country. This proposal is expected to provide new data on the reasons and mechanisms behind the increasing rates of T1D and other immune-mediated diseases seen in most developed countries after World War II.

Appel à propositions

FP7-HEALTH-2007-A
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Coordinateur

HELSINGIN YLIOPISTO
Adresse
Yliopistonkatu 3
00014 Helsingin Yliopisto
Finlande

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Katariina Vainio-Mattila (Ms.)
Contribution de l’UE
€ 1 604 372

Participants (11)

HELSINGIN JA UUDENMAAN SAIRAANHOITOPIIRIN KUNTAYHTYMÄ
Finlande
Contribution de l’UE
€ 494 108
Adresse
Stenbackinkatu 9
00029 Helsinki

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Type d’activité
Research Organisations
Contact administratif
Anne Karikumpu (Ms.)
SIHTASUTUS TARTU ULIKOOLI KLIINIKUM
Estonie
Contribution de l’UE
€ 297 580
Adresse
Puusepa 1a
50406 Tartu

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Type d’activité
Research Organisations
Contact administratif
Vallo Tillmann (Prof.)
Ministry of Health and Social Development, Karelian Republic of the Russian Federation
Russie
Contribution de l’UE
€ 191 748
Adresse
Lenin Street, 6
185035 Petrozavodsk

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Type d’activité
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Contact administratif
Valentina Ulich (Dr.)
TERVEYDEN JA HYVINVOINNIN LAITOS
Finlande
Contribution de l’UE
€ 565 664
Adresse
Mannerheimintie 166
00271 Helsinki

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Type d’activité
Research Organisations
Contact administratif
Jaakko Penttinen (Mr.)
TAMPEREEN YLIOPISTO
Finlande
Contribution de l’UE
€ 993 180
Adresse
Kalevantie 4
33014 Tampere

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Hannele Auffermann (Ms.)
TURUN YLIOPISTO
Finlande
Contribution de l’UE
€ 974 330
Adresse
Yliopistonmaki
20014 Turku

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Eliisa Särkilahti (Dr.)
TARTU ULIKOOL
Estonie
Contribution de l’UE
€ 140 560
Adresse
Ulikooli 18
51005 Tartu

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Raivo Uibo (Prof.)
OU IMMUNOTRON
Estonie
Contribution de l’UE
€ 49 781
Adresse
Riia 185
51014 Tartu

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Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Raivo Uibo (Dr.)
Petrozavodsk State University
Russie
Contribution de l’UE
€ 98 729
Adresse
Lenin Street 33 33
185640 Petrozavodsk

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Natalya Dorshakova (Prof.)
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Allemagne
Contribution de l’UE
€ 189 592
Adresse
Geschwister Scholl Platz 1
80539 Muenchen

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Erika Von Mutius (Prof.)
ACADEMISCH ZIEKENHUIS GRONINGEN
Pays-Bas
Contribution de l’UE
€ 400 256
Adresse
Hanzeplein 1
9713 GZ Groningen

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Elisabeth W.H.M. Eijdems (Dr.)