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Pathogenesis of Type 1 Diabetes - Testing the Hygiene Hypothesis

Ziel

Preliminary data indicate that there is a strong association between the incidence of immune-mediated diseases and improving standard of living and hygiene. One of the steepest gradient in standard of living worldwide is present at the border between Russian Karelia and Finland with a sevenfold difference in the gross national product, while Estonia represents a country in rapid transition. These three populations comprise a “living laboratory” providing a unique possibility to test the hygiene hypothesis in the development of immune-mediated diseases. The incidence of type 1 diabetes (T1D) is six times lower in Russian Karelia than in Finland, whereas there are very limited differences in the frequency of risk HLA genotypes in the background population. This proposal aims at comparing (i) the frequency of beta-cell autoimmunity and other organ-specific autoantibodies; (ii) the frequency of IgE-specific sensitisation and signs of allergy; (iii) the frequency of various infections; (iv) the gut microbial flora; and (v) dietary intake in young children between the three populations. The birth cohort arm of the study aims at (i) delineating the ontogeny of the immune system by using modern tools of functional genomics; (ii) comparing the functional characteristics of regulatory T cells; (iii) characterising the gut microbial colonisation in infants; (iv) assessing the timing of exposure to foreign proteins in infancy (v) defining the interrelations between dietary factors, gut microbial flora and acute microbial infections. The objectives will be approached by studying 1600 children at the age of 3 and 5 years and by observing a birth cohort comprising about 320 subjects with HLA-conferred susceptibility to autoimmunity from birth up to the age of 3 years in each country. This proposal is expected to provide new data on the reasons and mechanisms behind the increasing rates of T1D and other immune-mediated diseases seen in most developed countries after World War II.

Aufforderung zur Vorschlagseinreichung

FP7-HEALTH-2007-A
Andere Projekte für diesen Aufruf anzeigen

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HELSINGIN YLIOPISTO
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Yliopistonkatu 3
00014 Helsingin Yliopisto
Finnland

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Higher or Secondary Education Establishments
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Katariina Vainio-Mattila (Ms.)
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€ 1 604 372

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HELSINGIN JA UUDENMAAN SAIRAANHOITOPIIRIN KUNTAYHTYMÄ
Finnland
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Stenbackinkatu 9
00029 Helsinki

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Anne Karikumpu (Ms.)
SIHTASUTUS TARTU ULIKOOLI KLIINIKUM
Estland
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Puusepa 1a
50406 Tartu

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Vallo Tillmann (Prof.)
Ministry of Health and Social Development, Karelian Republic of the Russian Federation
Russland
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€ 191 748
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Lenin Street, 6
185035 Petrozavodsk

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Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
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Valentina Ulich (Dr.)
TERVEYDEN JA HYVINVOINNIN LAITOS
Finnland
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Mannerheimintie 166
00271 Helsinki

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Jaakko Penttinen (Mr.)
TAMPEREEN YLIOPISTO
Finnland
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Kalevantie 4
33014 Tampere

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Hannele Auffermann (Ms.)
TURUN YLIOPISTO
Finnland
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Yliopistonmaki
20014 Turku

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Eliisa Särkilahti (Dr.)
TARTU ULIKOOL
Estland
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Ulikooli 18
51005 Tartu

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Higher or Secondary Education Establishments
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Raivo Uibo (Prof.)
OU IMMUNOTRON
Estland
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Riia 185
51014 Tartu

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Raivo Uibo (Dr.)
Petrozavodsk State University
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185640 Petrozavodsk

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Natalya Dorshakova (Prof.)
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Deutschland
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Geschwister Scholl Platz 1
80539 Muenchen

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Erika Von Mutius (Prof.)
ACADEMISCH ZIEKENHUIS GRONINGEN
Niederlande
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Hanzeplein 1
9713 GZ Groningen

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Elisabeth W.H.M. Eijdems (Dr.)