Objetivo The development of new strategies that allow increasingly rapid access to structural complexity remains one of the fundamental challenge for the chemical sciences. While the total synthesis approach to molecular complexity is generally based on a costly sequence of individual reactions, it is intriguing to consider that biological systems produce elaborate molecules in an economic continuous process, wherein enzymatic transformations are combined in highly regulated catalytic cascades. Therefore in order to improve the production of complex molecules, lessons learned from Nature could be beneficial for the chemical synthesis. Over the past few years, the field of asymmetric organocatalysis has literally exploded. As one of the pioneering groups in the field, the MacMillan group has reported various groundbreaking catalytic asymmetric reactions based on organocatalysts of their original design. In 2005, MacMillan introduced for the first time the concept of enantioselective organo-cascade catalysis, a powerful strategy that provides rapid access to structural complexity from simple starting materials. In this proposal a strategic approach towards a total synthesis of 12-deoxy phorbol is viewed to demonstrate the applicability and the efficiency of cascade catalysis in the context of the total synthesis of natural products. By employing cascade catalysis in the key bond constructing manipulations, the synthesis of 12-deoxy phorbol, should be achieved in only one-third of the steps that had been required for previous synthetic studies of the phorbol skeleton. The return phase will be dedicated to a not less attractive and exciting field of chemistry where the access to structural complexity is also a challenge: the nanotechnology. This stay in the Leigh Group will allow the researcher to transfer her knowledge and expertise acquired in the field of synthetic organic chemistry to the development of the first organocatalytic active template synthesis of rotaxanes. Ámbito científico natural scienceschemical sciencesorganic chemistryengineering and technologynanotechnologynatural scienceschemical sciencescatalysis Palabras clave Asymmetric catalysis Cascade reactions Homogeneous catalysis Nanotechnology Natural product synthesis Organic chemistry Organocatalysis rotaxanes Programa(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) PEOPLE-2007-4-1.IOF - Marie Curie Action: "International Outgoing Fellowships for Career Development" Convocatoria de propuestas FP7-PEOPLE-2007-4-1-IOF Consulte otros proyectos de esta convocatoria Régimen de financiación MC-IOF - International Outgoing Fellowships (IOF) Coordinador THE UNIVERSITY OF EDINBURGH Aportación de la UE € 155 104,54 Dirección OLD COLLEGE, SOUTH BRIDGE EH8 9YL Edinburgh Reino Unido Ver en el mapa Región Scotland Eastern Scotland Edinburgh Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Angela Noble (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Participantes (1) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo TRUSTEES OF PRINCETON UNIVERSITY Estados Unidos Aportación de la UE Sin datos Dirección NASSAU HALL 1 08544-2001 Princeton, Nj Ver en el mapa Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Kathy Niebo (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos