Cel The development of new strategies that allow increasingly rapid access to structural complexity remains one of the fundamental challenge for the chemical sciences. While the total synthesis approach to molecular complexity is generally based on a costly sequence of individual reactions, it is intriguing to consider that biological systems produce elaborate molecules in an economic continuous process, wherein enzymatic transformations are combined in highly regulated catalytic cascades. Therefore in order to improve the production of complex molecules, lessons learned from Nature could be beneficial for the chemical synthesis. Over the past few years, the field of asymmetric organocatalysis has literally exploded. As one of the pioneering groups in the field, the MacMillan group has reported various groundbreaking catalytic asymmetric reactions based on organocatalysts of their original design. In 2005, MacMillan introduced for the first time the concept of enantioselective organo-cascade catalysis, a powerful strategy that provides rapid access to structural complexity from simple starting materials. In this proposal a strategic approach towards a total synthesis of 12-deoxy phorbol is viewed to demonstrate the applicability and the efficiency of cascade catalysis in the context of the total synthesis of natural products. By employing cascade catalysis in the key bond constructing manipulations, the synthesis of 12-deoxy phorbol, should be achieved in only one-third of the steps that had been required for previous synthetic studies of the phorbol skeleton. The return phase will be dedicated to a not less attractive and exciting field of chemistry where the access to structural complexity is also a challenge: the nanotechnology. This stay in the Leigh Group will allow the researcher to transfer her knowledge and expertise acquired in the field of synthetic organic chemistry to the development of the first organocatalytic active template synthesis of rotaxanes. Dziedzina nauki natural scienceschemical sciencesorganic chemistryengineering and technologynanotechnologynatural scienceschemical sciencescatalysis Słowa kluczowe Asymmetric catalysis Cascade reactions Homogeneous catalysis Nanotechnology Natural product synthesis Organic chemistry Organocatalysis rotaxanes Program(-y) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) PEOPLE-2007-4-1.IOF - Marie Curie Action: "International Outgoing Fellowships for Career Development" Zaproszenie do składania wniosków FP7-PEOPLE-2007-4-1-IOF Zobacz inne projekty w ramach tego zaproszenia System finansowania MC-IOF - International Outgoing Fellowships (IOF) Koordynator THE UNIVERSITY OF EDINBURGH Wkład UE € 155 104,54 Adres OLD COLLEGE, SOUTH BRIDGE EH8 9YL Edinburgh Zjednoczone Królestwo Zobacz na mapie Region Scotland Eastern Scotland Edinburgh Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Angela Noble (Ms.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych Uczestnicy (1) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko TRUSTEES OF PRINCETON UNIVERSITY Stany Zjednoczone Wkład UE Brak danych Adres NASSAU HALL 1 08544-2001 Princeton, Nj Zobacz na mapie Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Kathy Niebo (Ms.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych
