Objective
The identification of the genetic variants underlying adaptive traits constitutes one of the major challenges for modern biology. In this proposal we focus on the ability of plants to tolerate low temperatures. The molecular basis of cold tolerance has been widely investigated in crop species since freezing temperatures can severely affect quality, yield and production. Through the use of the model plant species Arabidopsis thaliana a dramatic increase in the understanding of the genetic mechanisms underlying cold tolerance was achieved. However, many questions remain still open with regard to the nature of the genes involved in the response of plants to cold temperatures. In this project an original, interdisciplinary strategy will be adopted to address naturally occurring variation for cold tolerance in A. thaliana. First, with the aim of identifying the genes underlying variation for cold tolerance in A. thaliana, association mapping will be performed, making use of a set of 1300 A. thaliana accessions, genotyped for 250.000 Single Nucleotide Polymorphisms. In contrast to classical linkage mapping, association mapping has the potential to identify single or a few genes. However, it is affected by population structure, which can eventually lead to a high rate of false positives. Therefore, F2 and F3 progenies will be designed, and used in classical linkage mapping to confirm that associations are due to linkage with causative polymorphisms rather than being spurious correlations due to population structure. Second, to elucidate the selective forces to which the loci identified in the association study have been submitted nucleotide variation will be analyzed at the loci as well as at their surrounding genomic regions and compared to the genome-wide polymorphism pattern. Finally, the candidate loci for cold tolerance identified through association mapping will be submitted to functional analyses in order to confirm their implication in cold tolerance.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences mathematics pure mathematics mathematical analysis functional analysis
- agricultural sciences agriculture, forestry, and fisheries agriculture
- natural sciences biological sciences genetics nucleotides
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2007-4-1-IOF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
80539 MUNCHEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.