Obiettivo Although our knowledge about the function of basic biological elements such as genes and proteins has grown considerably, we lack a comprehensive picture of how these elements act in coordination, and our ability to modulate their function is still limited. Here, I propose a global study of motif-mediated protein interactions that aims to find interactions that can be modulated by small molecules or peptides, and their roles in the organization of signaling pathways. I will use one of the best-understood eukaryotic model organism Saccharomyces cerevisiae, for which several large-scale functional, interaction and chemical-genetic datasets are available. In addition, the genome sequences for more than a dozen of yeast species are largely complete. I will identify motif-mediated interactions using these proteomic and comparative data, and integrate them with large-scale chemical-genetic datasets to explore the correlations between genetic interactions and small molecules. I will test my predictions and study cellular pathways cross-talk using modelling and combinatorial protein interaction interference. With such a systematic approach, I aim to reveal the fundamental principles of how protein function can be modulated, and how these principles might carry over to vertebrates. Campo scientifico scienze naturaliscienze biologichebiochimicabiomolecoleproteinescienze naturaliscienze biologichegeneticagenomi Parole chiave Saccharomyces cerevisiae chemical-genetics interaction modulation protein linear motifs protein-protein interactions signal transduction pathways Programma(i) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Argomento(i) PEOPLE-2007-2-1.IEF - Marie Curie Action: "Intra-European Fellowships for Career Development" Invito a presentare proposte FP7-PEOPLE-2007-2-1-IEF Vedi altri progetti per questo bando Meccanismo di finanziamento MC-IEF - Intra-European Fellowships (IEF) Coordinatore THE UNIVERSITY OF EDINBURGH Indirizzo Old college, south bridge EH8 9YL Edinburgh Regno Unito Mostra sulla mappa Regione Scotland Eastern Scotland Edinburgh Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Angela Noble (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Contributo UE Nessun dato
