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Novel Polysaccharide Modifying Enzymes to Optimise the Potential of Hydrocolloids for Food and Medical Applications

Objective

The PolyModE project convenes an international, interdisciplinary, and intersectorial consortium to identify, characterise, and optimise novel polysaccharide modifying enzymes, and to develop robust fermentation strategies for their large-scale production, to exploit the potential of biopolymers for food, pharmaceutical, cosmetic, and technical applications. We have selected the six complex carbohydrates with the highest current market share or expected future market potential, namely alginate, carrageenan, chitosan, glycosaminoglycan, pectin, and xanthan gum. For each of these, the industrial partners have identified those enzymes which will answer to the most pressing needs or offer the most promising potential for improved production of polysaccharides with novel physico-chemical properties and biological functionalities. Primary targets will be alginate epimerases, carrageenan sulfatases, chitosan de-acetylases, glycosaminoglycan sulfatases, pectin de-acetylases, and xanthan gum de-acetylases. These enzymes together with secondary target enzymes, e.g. sequence specific lyases and hydrolases, will allow the generation and analysis of polymers and oligomers with novel, non-random patterns of modification. Two parallel approaches will be followed for each type of polysaccharide modifying enzyme, namely a knowledge-based genomic approach and a broad, un-biased metagenomic approach, e.g. using soil or sludge samples with a history of contact with the polysaccharide in question. A pipeline of three levels of fermentation systems will be established, ranging from lab-scale innovative expression systems with features shaped according to the specific characteristics of our target enzymes, through medium-scale, novel and unusual fermentation systems provided by a number of SME with highly specialised knowledge and expertise in developing and using such systems, to the established large-scale fermentation systems and facilities of market leaders in White Biotechnology.

Field of science

  • /social sciences/economics and business/business and management/commerce
  • /natural sciences/biological sciences/biochemistry/biomolecules/carbohydrates
  • /natural sciences/chemical sciences/polymer science
  • /engineering and technology/industrial biotechnology/bioprocessing technologies/fermentation
  • /humanities/history and archaeology/history
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/enzymes

Call for proposal

FP7-KBBE-2007-2A
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

Westfälische Wilhelms-Universität Münster
Address
Schlossplatz 2
48149 Muenster
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 050 192
Administrative Contact
Bruno Moerschbacher (Prof.)

Participants (14)

INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
France
EU contribution
€ 699 600
Address
147 Rue De L'universite
75007 Paris Cedex 07
Activity type
Research Organisations
Administrative Contact
Angelo Trussardi (Mr.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 729 248
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
Administrative Contact
Florence Morineau (Ms.)
WAGENINGEN UNIVERSITY
Netherlands
EU contribution
€ 747 208
Address
Droevendaalsesteeg 4
6708 PB Wageningen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jos Teunissen (Mr.)
SVERIGES LANTBRUKSUNIVERSITET
Sweden
EU contribution
€ 566 000
Address
Almas Alle 8
750 07 Uppsala
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ingrid Ragnarsdotter Jajke (Ms.)
THE STEPHAN ANGELOFF INSTITUTE OF MICROBIOLOGY, BULGARIAN ACADEMY OF SCIENCES
Bulgaria
EU contribution
€ 434 000
Address
Acad Georgi Bonchev 26
1113 Sofia
Activity type
Research Organisations
Administrative Contact
Pavlinka Angelova (Dr.)
DUPONT NUTRITION BIOSCIENCES APS
Denmark
EU contribution
€ 591 500
Address
Langebrogade 1
1001 Copenhagen K
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Lisbeth Munksgaard (Ms.)
SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT
France
EU contribution
€ 135 000
Address
Pierre Brossolette 1
91380 Chilly Mazarin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Frédéric Galli (Dr.)
GILLET CHITOSAN EURL
France
EU contribution
€ 60 000
Address
Laurent Bonnevay 17
54100 Nancy
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Dominique Gillet (Mr.)
GENEART AG
Germany
EU contribution
€ 216 000
Address
Josef-engert-strasse 9
93053 Regensburg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ralf Wagner (Prof.)
LIBRAGEN
France
EU contribution
€ 120 000
Address
Rue Des Satellites 3
31400 Toulouse
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Renaud Nalin (Mr.)
ARTES BIOTECHNOLOGY GmbH
Germany
EU contribution
€ 120 000
Address
Elisabeth-selbert-str. 9
40764 Langenfeld
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Michael Piontek (Dr.)
GTP TECHNOLOGY SA
France
EU contribution
€ 124 800
Address
Rue Pierre Et Marie Curie, Immeuble Biostep
31681 Labege
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Nathalie Risse (Ms.)
LYON INGENIERIE PROJETS
France
EU contribution
€ 323 200
Address
Bd Du 11 Novembre 1918 43 L Atrium
69616 Villeurbanne
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Javier Olaiz (Dr.)
PETRA TEWES-SCHWARZER - CARE SENSE CONSULTING
Germany
EU contribution
€ 83 200
Address
Merschwiese 2A
48308 Senden
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Petra Tewes-Schwarzer (Ms.)