Obiettivo
The overarching goal of COGS is to identify individuals with an increased risk of breast, ovary and prostate cancer. Furthermore, we will evaluate the effect of inherited genetic variation on tumour characteristics and clinical outcome. We will do this through quantifying the role of genetic and environmental/lifestyle risk in the largest data set ever generated. In all, we will include over 200,000 individuals in the COGS project. We will use detailed knowledge of the architecture of genetic susceptibility and interactions with environmental/lifestyle factors which will result in much more accurate individual risk prediction and improved intervention strategies. We are taking advantage of a unique possibility by incorporating seven existing consortia into one large project – COGS. Members of these consortia have collaborated successfully over the past years and results have been presented in world leading scientific journals such as Nature, Nature Genetics and Journal of the National Cancer Institute. These papers reflect that collaboration has been ongoing and that is has so far been very successful. We will also build on an existing European Commission project, TRANSBIG, thus adding value to already spent money. Results generated through COGS will lead to an improved understanding of the biological processes that underlie carcinogenesis, that in turn could guide new therapeutic strategies. Results will also lead to the development of new tests for risk prediction for breast, ovarian and prostate cancer.
Campo scientifico
Parole chiave
Argomento(i)
Invito a presentare proposte
FP7-HEALTH-2007-B
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Meccanismo di finanziamento
CP-IP - Large-scale integrating projectCoordinatore
17177 Stockholm
Svezia
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Partecipanti (15)
CB2 1TN Cambridge
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QLD 4006 Herston
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69120 Heidelberg
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28029 Madrid
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22100 LUND
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00029 Helsinki
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1066 CX Amsterdam
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CB1 8RN Cambridge
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2100 Koebenhavn
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1000 BRUXELLES
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SW7 3RP London
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69373 Lyon
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WC1E 6BT LONDON
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3004 Melbourne Victoria
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CV4 8UW COVENTRY
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