Objectif
Mitochondrial dysfunction is a major hallmark of various neurodegenerative disorders including Alzheimer’s disease, Parkinson’s disease, Huntington’s diseases or Amyotrophic Lateral Sclerosis (ALS). However linking mitochondrial dysfunction to the pathogenesis of some of these diseases still needs to be elucidated. Furthermore, in pathologies where this link is already established, the question remains whether specific targets or mechanisms involved in mitochondrial dysfunction will be amenable to therapeutic intervention. MitoTarget is an ambitious project aimed at providing solid data to better understand and exploit the circumstantial evidence linking mitochondrial dysfunction with neuronal dysfunction culminating in neurodegenerative disease. A 36 months translational research program will bring together a unique partnership between basic scientists, a seasoned team of clinical investigators and a SME that has identified a first-in-class compound, TRO19622, that targets mitochondria and has powerful neuroprotective and neuroregenerative activities. In parallel, and orchestrated by the SME that is the coordinator of the project, MitoTarget will bring together a more comprehensive insight into the mechanisms leading to mitochondrial impairments and establish their clinical relevance in a severe orphan neurodegenerative disease, ALS. If successful, it is expected that from this proof of principle a new class of therapeutic agents targeting the underlying mitochondrial dysfunction in neurons or their supporting cells will emerge. Results of the project have the potential to create a new paradigm for the drug discovery for neurodegenerative diseases.
Champ scientifique
- medical and health sciencesbasic medicinepharmacology and pharmacydrug discovery
- medical and health sciencesbasic medicineneurologydementiaalzheimer
- medical and health sciencesbasic medicinepathology
- medical and health sciencesbasic medicineneurologyparkinson
- medical and health sciencesbasic medicineneurologyamyotrophic lateral sclerosis
Mots‑clés
Appel à propositions
FP7-HEALTH-2007-B
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Régime de financement
CP-FP - Small or medium-scale focused research projectCoordinateur
13288 MARSEILLE CEDEX 9
France
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Participants (17)
S10 2TN Sheffield
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72074 Tuebingen
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60323 Frankfurt Am Main
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75012 Paris
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06003 Nice
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10117 Berlin
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30625 Hannover
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WC2R 2LS London
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3000 Leuven
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Participation terminée
3584 CX Utrecht
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34000 Montpellier
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6108 Halle
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59037 Lille
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87000 Limoges
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89081 Ulm
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69002 Lyon
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13284 Marseille
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