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Regeneration of Cardiac Tissue Assisted by Bioactive Implants

Ziel

Heart failure is the end-stage of many cardiovascular diseases, but the leading cause is the presence of a large scar due acute to myocardial infarction. Current therapeutic treatments under development consist in cellular cardiomyoplasty where myocardial cells or stem cells are implanted alone or encapsulated in natural scaffolds (collagens) and grafted onto infarcted ventricles with the hope that cells will contribute to the generation of new myocardial tissue. This approach seems to have a beneficial effect although it is not completely understood and optimized, yet. Thus, the urgent need of better therapeutic platforms is imminent. In view of this, we created a small interdisciplinary consortium (RECATABI) with experts in areas such as material sciences, tissue engineering, stem cell technologies and clinical cardiovascular research. RECATABI will integrate and synergise their capacities in order to obtain a novel clinical platform to regenerate necrotic ischemic tissues after cardiac infarct with a simple one-time patch technology application. The consortium will accomplish this by fabricating nanoscale engineered biomaterials and scaffolds that will match the exact biomechanical and biophysical requirements of the implanted tissue. In addition, the construct may induce rapid vascularization to ensure tissue remodelling and regeneration into a newly functional myocardium. The regenerative capacity of the implants loaded with pre-adapted cells (biomechanically and biophysically trained) will be assessed in small (rodents) and large (sheep) animal models.

Aufforderung zur Vorschlagseinreichung

FP7-NMP-2008-SMALL-2
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

CP-FP - Small or medium-scale focused research project

Koordinator

INSTITUT QUIMIC DE SARRIA
Adresse
Calle Via Augusta 384-394
08017 Barcelona
Spanien
Aktivitätstyp
Higher or Secondary Education Establishments
EU-Beitrag
€ 462 987,40
Kontakt Verwaltung
Carlos Semino (Prof.)

Beteiligte (6)

FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Deutschland
EU-Beitrag
€ 397 023,25
Adresse
Hansastrasse 27C
80686 Munchen
Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Andrea Zeumann (Ms.)
UNIVERSITAT POLITECNICA DE VALENCIA
Spanien
EU-Beitrag
€ 304 185,75
Adresse
Camino De Vera Sn Edificio 3A
46022 Valencia
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Jose-Antonio Perez-Garcia (Mr.)
INSTITUT DE INVESTIGACIO EN CIENCIES DE LA SALUT GERMANS TRIAS I PUJOL
Spanien
EU-Beitrag
€ 410 224,80
Adresse
Ctra De Canyet S/n
08916 Badalona Barcelona
Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Antonio Martín (Mr.)
ASSOCIATION CARDIO-MONDE
Frankreich
EU-Beitrag
€ 370 120,80
Adresse
Rue De La Tour 116
75116 Paris
Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Juan Carlos Chachques (Dr.)
CREASPINE SAS
Frankreich
EU-Beitrag
€ 383 760
Adresse
Ptib Hopital Xavier Arnozan Avenue Du Haut Leveque
33600 Pessac
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt Verwaltung
Philippe Jenny (Mr.)
INSTITUT DE RECERCA DE L'HOSPITAL DE LA SANTA CREU I SANT PAU FUNDACION

Beteiligung beendet

Spanien
Adresse
C Sant Quinti 77-79
08041 Barcelona
Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Hilda Herrero (Ms.)