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Contenuto archiviato il 2024-06-18

Synthesis of Targeted Organometallic Anticancer Drugs and their mode of Action

Obiettivo

The project is designed to study a new class of ruthenium antimetastasis compounds, which provides a flexible scaffold onto which various groups of known biological function can be grafted, in order to identify the mechanism of antimetastasis action and obtain superior compounds. In addition, targets will be identified from these compounds using an innovative bio-analytical method. The generic compound which will be used for the study are based on the general structure, Ru(η6-arene)Cl2(pta), and biologically active groups with known therapeutic function, e.g. that induce cell cycle arrest, will be tethered to the arene ring or attached via the ruthenium centre. Key protein targets will then be identified by laser ablation inductively coupled plasma mass spectrometry (ICP-MS). The influence of the inhibitors will be studied and the effect on drug efficacy explored. Drug binding sites will be identified using a mass spectrometric bottom-up or top-down methods which will be very much useful in directing future drug design.

Invito a presentare proposte

FP7-PEOPLE-IIF-2008
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Coordinatore

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Contributo UE
€ 189 163,26
Indirizzo
BATIMENT CE 3316 STATION 1
1015 Lausanne
Svizzera

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Regione
Schweiz/Suisse/Svizzera Région lémanique Vaud
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Paul Dyson (Prof.)
Collegamenti
Costo totale
Nessun dato