Final Report Summary - AXOGLIA (Understanding the axon-glial functional unit in myelination and remyelination)
Our lack of a clear understanding of the general mechanisms underlying myelination and remyelination arises in part from the fact that most of the studies have been relying on conventional molecular, biochemical and cellular methodologies which permit to successfully address one or a few identified molecules of interest but cannot provide a complete profile of the complex events underlying these processes.
This fellowship aimed to combine this classical approach to systems biology approach. Conventional molecular, biochemical and cellular methodologies have been applied to study a previously identified interesting candidate (i.e. Profilin 1, see 1 below) for its role in PNS and CNS myelination. A system biology approach has been applied to identify new potential candidates likely to play a role in CNS myelination/remyelination (or its failure) (see 2 below).