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Chromatin diseases: from basic mechanisms to therapy

Objectif

The scope of this ITN is to promote research and training in the field of chromatin diseases. Chromatin diseases (CD) are genetic pathologies resulting from mutations in structural components of chromatin or in enzymes that biochemically modify chromatin, altering chromatin status and thereby causing drastic effects on gene expression. CD frequency ranges from very rare to quite common pathologies; so far for the vast majority of them no treatment is as yet available. Molecular studies on these pathologies thus have a twofold value: to shed light on the intricate interplays between different levels of control of gene expression acting in the mammalian nucleus and to pave the way toward new and more effective strategies to approach the treatment of this increasing class of diseases. Our students will take advantage of the integrated approach on multilayered gene regulation, the multidisciplinary nature and the cutting-edge methodologies, which are an integral part of this proposal. We thus expect to provide a framework for the very high-level training of young researchers, receiving a strong backgrounds in molecular, cellular and developmental biology, genomics, bioinformatics, chromatin biology and epigenetics. Furthermore, they will develop expertise in many cutting edge methodologies and tools, such as imaging, high throughput gene technologies, ChIP. As a result, the ESRs will be highly competitive in performing independent research in various areas of biology and will represent a new breed of scientists trained in contemporary post-genomic biology using advanced technological tools to tackle human disease.

Appel à propositions

FP7-PEOPLE-ITN-2008
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Coordinateur

CONSIGLIO NAZIONALE DELLE RICERCHE
Adresse
Piazzale Aldo Moro 7
00185 Roma
Italie

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Type d’activité
Research Organisations
Contact administratif
Antonio Baldini (Prof.)
Contribution de l’UE
€ 564 827

Participants (10)

UNIVERSITE DE LA MEDITERRANEE D'AIX-MARSEILLE II

Participation terminée

France
Adresse
Boulevard Charles Livon, Jardin Du Pharo 58
13284 Marseille
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Celine Damon (Ms.)
BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING
Grèce
Contribution de l’UE
€ 371 880
Adresse
Fleming Street 34
16672 Vari-athens

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Type d’activité
Research Organisations
Contact administratif
George Kollias (Dr.)
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Contribution de l’UE
€ 219 751
Adresse
Trinity Lane The Old Schools
CB2 1TN Cambridge

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Edna Murphy (Ms.)
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Contribution de l’UE
€ 213 151
Adresse
Wellington Square University Offices
OX1 2JD Oxford

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Lynne Hughson (Ms.)
FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE
Espagne
Contribution de l’UE
€ 380 355
Adresse
Avenida Gran Via Hospitalet 199-203
08908 L'hospitalet De Llobregat

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Type d’activité
Research Organisations
Contact administratif
Victoria Cochrane (Ms.)
UNIVERSITA DEGLI STUDI DI MODENA E REGGIO EMILIA
Italie
Contribution de l’UE
€ 212 351
Adresse
Via Universita 4
41121 Modena

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Sebastiano Calandra Buonaura (Prof.)
UNIVERSITA DEGLI STUDI DELL'INSUBRIA
Italie
Contribution de l’UE
€ 205 751
Adresse
Via Ravasi 2
21100 Varese

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Adriana Jacona (Mr.)
UNIVERSITE D'AIX MARSEILLE
France
Contribution de l’UE
€ 206 452
Adresse
Boulevard Charles Livon 58 Le Pharo
13284 Marseille

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Celine Damon (Ms.)
DIAGENODE
Belgique
Contribution de l’UE
€ 200 309
Adresse
Rue Du Bois Saint Jean 3 Liege Park Science
4102 Seraing

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Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Leon Etienne (Mr.)
UCL Elizabeth Garrett Anderson Institute for Women’s Health

Participation terminée

United Kingdom
Adresse
Gower Street
WC1E 6BT London
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Greta Borg-Carbott (Ms.)