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Genetic and phenotipic characterization of emerging hypervirulent Clostridium difficile: role and regulation of virulence factors

Ziel

Clostridium difficile is a Gram-positive, spore-forming anaerobic bacillus that often resides in the gut of mammals and is the causative agent of the illness C. difficile infection (CDI). The hospital environment and patients undergoing antibiotic treatment provide a discrete ecosystem where C. difficile persists and select virulent clones thrive. CDI is the most frequent cause of infectious diarrhea in hospitals worldwide, causing in the last decade outbreaks of increased severity in Europe and North America. The continued rise of CDI worldwide has been accompanied by the rapid emergence and transcontinental spread of at least two highly virulent clones that are commonly referred to as 027 and A-B+. The overall aim of this project is to determine the genetic and phenotypic attributes that might explain the emergence of these hypervirulent 027 strains. To this end we will obtain mutants in genes we suspect to be important for 027 strains virulence. Those mutants will be characterized in detail by genetic and phenotypical studies. This project provides a unique opportunity to study the recent emergence of virulence and will contribute more generally to our understanding of how bacterial pathogens evolve.

Aufforderung zur Vorschlagseinreichung

FP7-PEOPLE-2009-IEF
Andere Projekte für diesen Aufruf anzeigen

Koordinator

LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER
EU-Beitrag
€ 172 740,80
Adresse
KEPPEL STREET
WC1E 7HT London
Vereinigtes Königreich

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Region
London Inner London — West Camden and City of London
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Jana Sabinovska (Ms.)
Links
Gesamtkosten
Keine Daten