Obiettivo
Metal catalyzed C-H bond functionalization reactions is an area of organic synthesis having an exponential development and a great acceptation in the chemist community because meets the ideals of green chemistry. In this proposal we present a project research based on the development of new strategies of C-H bond activation/cycloaddition that leads to the formation of functionalized heterocycles. Furthermore the methodology is proposed to be applied to the synthesis of piperidine acid analogs, known prenyltransferase inhibitors. The inhibition of prenyltransferases could prevent the proper functioning of the Ras (protein), which is commonly abnormally active in cancer, and it could be key for the development of new therapeutics in the fight against this widespread illness.
Campo scientifico
Invito a presentare proposte
FP7-PEOPLE-2009-RG
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Meccanismo di finanziamento
MC-ERG - European Re-integration Grants (ERG)Coordinatore
15782 Santiago De Compostela
Spagna