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Determining (epi)genetic therapeutic signatures for improving lung cancer prognosis

Objectif

Lung cancer (LC) is still the most lethal type of cancer worldwide. The extremely poor prognosis for LC patients is partly due to the lack of effective therapies. At present, most patients with pulmonary carcinomas are treated with chemotherapy. This essentially consists of classic cytotoxic drugs which only improve survival in small cohorts in few cases. In spite of the rapidly growing understanding of the epigenetic and genetic profile of LC, such knowledge has contributed little to improving therapeutics. This scenario, however, is likely to change soon because several specific cancer therapies, targeting molecules that are altered in cancer, are being developed or are already undergoing clinical trials. Thinking ahead, our proposal focuses, on the one hand, on validating novel and specific therapeutic strategies, with particular emphasis on discovering (epi)genetic alterations that could act as novel targets for therapies, and, on the other, on defining the (epi)genetic markers that could determine the efficacy response or resistance to targeted therapies as well as the acquired resistance of the tumours to therapy. To reach our goals, we have designed an integrative and interdisciplinary approach involving leading European clinical scientists of international renown with prominent preclinical and basic research groups using high throughput and state-of-the art platforms for genomics and gene expression analysis. To date, no such comprehensive information exists. The results will be of great value for the stratification of lung tumours according to their genetic background for tailored treatments. The development of an (epi)genetic-based therapeutic prediction model will hopefully set the basis for future tailored treatment of LC as well as of other epithelial cancers.

Appel à propositions

FP7-HEALTH-2010-two-stage
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Coordinateur

FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE
Adresse
Avenida Gran Via Hospitalet 199-203
08908 L'hospitalet De Llobregat
Espagne
Type d’activité
Research Organisations
Contribution de l’UE
€ 798 520
Contact administratif
Verónica Padial (Mrs.)

Participants (10)

THE UNIVERSITY OF LIVERPOOL
United Kingdom
Contribution de l’UE
€ 298 370
Adresse
Brownlow Hill 765 Foundation Building
L69 7ZX Liverpool
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Veronica Shaw (Ms.)
UNIVERSITE JOSEPH FOURIER GRENOBLE 1
France
Contribution de l’UE
€ 279 600
Adresse
Avenue Centrale, Domaine Universitaire 621
38041 Grenoble
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Leslie Hollett (Ms.)
FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA
Espagne
Contribution de l’UE
€ 280 024
Adresse
Avenida De Pio Xii 55
31008 Pamplona
Type d’activité
Research Organisations
Contact administratif
Andrew Solomon (Dr.)
MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.

Participation terminée

Allemagne
Contribution de l’UE
€ 73 119,82
Adresse
Hofgartenstrasse 8
80539 Muenchen
Type d’activité
Research Organisations
Contact administratif
Juergen Baaske (Mr.)
FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI
Italie
Contribution de l’UE
€ 279 000
Adresse
Via Venezian 1
20133 Milan
Type d’activité
Research Organisations
Contact administratif
Antonio Cannarozzo (Dr.)
UNIVERSITA DEGLI STUDI DI TORINO
Italie
Contribution de l’UE
€ 200 400
Adresse
Via Giuseppe Verdi 8
10124 Torino
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Giorgio Scagliotti (Prof.)
INSTITUT GUSTAVE ROUSSY
France
Contribution de l’UE
€ 150 000
Adresse
Rue Camille Desmoulins 39
94805 Villejuif
Type d’activité
Research Organisations
Contact administratif
Arnauld Forest (Mr.)
KLINIKUM DER UNIVERSITAET ZU KOELN
Allemagne
Contribution de l’UE
€ 332 380,18
Adresse
Kerpener Strasse 62
50937 Koeln
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Jutta Landvogt (Ms.)
KRZYSZTOF KUCHARCZYK TECHNIKI ELEKTROFORETYCZNE SPZOO
Pologne
Contribution de l’UE
€ 149 370
Adresse
Ul Adolfa Pawinskiego Nr 5A Lok D
02 106 Warszawa
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Krzysztof Kucharczyk (Dr.)
MRC HOLLAND B.V.
Pays-Bas
Contribution de l’UE
€ 124 965
Adresse
Willem Schoutenstraat 6
1057 DN Amsterdam
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Jan Schouten (Dr.)