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Determining (epi)genetic therapeutic signatures for improving lung cancer prognosis

Cel

Lung cancer (LC) is still the most lethal type of cancer worldwide. The extremely poor prognosis for LC patients is partly due to the lack of effective therapies. At present, most patients with pulmonary carcinomas are treated with chemotherapy. This essentially consists of classic cytotoxic drugs which only improve survival in small cohorts in few cases. In spite of the rapidly growing understanding of the epigenetic and genetic profile of LC, such knowledge has contributed little to improving therapeutics. This scenario, however, is likely to change soon because several specific cancer therapies, targeting molecules that are altered in cancer, are being developed or are already undergoing clinical trials. Thinking ahead, our proposal focuses, on the one hand, on validating novel and specific therapeutic strategies, with particular emphasis on discovering (epi)genetic alterations that could act as novel targets for therapies, and, on the other, on defining the (epi)genetic markers that could determine the efficacy response or resistance to targeted therapies as well as the acquired resistance of the tumours to therapy. To reach our goals, we have designed an integrative and interdisciplinary approach involving leading European clinical scientists of international renown with prominent preclinical and basic research groups using high throughput and state-of-the art platforms for genomics and gene expression analysis. To date, no such comprehensive information exists. The results will be of great value for the stratification of lung tumours according to their genetic background for tailored treatments. The development of an (epi)genetic-based therapeutic prediction model will hopefully set the basis for future tailored treatment of LC as well as of other epithelial cancers.

Zaproszenie do składania wniosków

FP7-HEALTH-2010-two-stage
Zobacz inne projekty w ramach tego zaproszenia

Koordynator

FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE
Adres
Avenida Gran Via Hospitalet 199-203
08908 L'hospitalet De Llobregat
Hiszpania
Rodzaj działalności
Research Organisations
Wkład UE
€ 798 520
Kontakt administracyjny
Verónica Padial (Mrs.)

Uczestnicy (10)

THE UNIVERSITY OF LIVERPOOL
United Kingdom
Wkład UE
€ 298 370
Adres
Brownlow Hill 765 Foundation Building
L69 7ZX Liverpool
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Higher or Secondary Education Establishments
Kontakt administracyjny
Veronica Shaw (Ms.)
UNIVERSITE JOSEPH FOURIER GRENOBLE 1
Francja
Wkład UE
€ 279 600
Adres
Avenue Centrale, Domaine Universitaire 621
38041 Grenoble
Rodzaj działalności
Higher or Secondary Education Establishments
Kontakt administracyjny
Leslie Hollett (Ms.)
FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA
Hiszpania
Wkład UE
€ 280 024
Adres
Avenida De Pio Xii 55
31008 Pamplona
Rodzaj działalności
Research Organisations
Kontakt administracyjny
Andrew Solomon (Dr.)
MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.

Zakończenie uczestnictwa

Niemcy
Wkład UE
€ 73 119,82
Adres
Hofgartenstrasse 8
80539 Muenchen
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Research Organisations
Kontakt administracyjny
Juergen Baaske (Mr.)
FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI
Włochy
Wkład UE
€ 279 000
Adres
Via Venezian 1
20133 Milan
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Research Organisations
Kontakt administracyjny
Antonio Cannarozzo (Dr.)
UNIVERSITA DEGLI STUDI DI TORINO
Włochy
Wkład UE
€ 200 400
Adres
Via Giuseppe Verdi 8
10124 Torino
Rodzaj działalności
Higher or Secondary Education Establishments
Kontakt administracyjny
Giorgio Scagliotti (Prof.)
INSTITUT GUSTAVE ROUSSY
Francja
Wkład UE
€ 150 000
Adres
Rue Camille Desmoulins 39
94805 Villejuif
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Research Organisations
Kontakt administracyjny
Arnauld Forest (Mr.)
KLINIKUM DER UNIVERSITAET ZU KOELN
Niemcy
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€ 332 380,18
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Kerpener Strasse 62
50937 Koeln
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Higher or Secondary Education Establishments
Kontakt administracyjny
Jutta Landvogt (Ms.)
KRZYSZTOF KUCHARCZYK TECHNIKI ELEKTROFORETYCZNE SPZOO
Polska
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€ 149 370
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Ul Adolfa Pawinskiego Nr 5A Lok D
02 106 Warszawa
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Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt administracyjny
Krzysztof Kucharczyk (Dr.)
MRC HOLLAND B.V.
Niderlandy
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€ 124 965
Adres
Willem Schoutenstraat 6
1057 DN Amsterdam
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Private for-profit entities (excluding Higher or Secondary Education Establishments)
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Jan Schouten (Dr.)