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EUCOMM: Tools for Functional Annotation of the Mouse Genome

Obiettivo

The EUCOMMTOOLS Collaborative Project responds to the topic ‘HEALTH.2010.2.1.1-1: Large-scale efforts in mouse functional genomics to determine the functions of genes and their involvement in disease.’ EUCOMMTOOLS will provide, in a systematic high-throughput way, genetic tools and resources contributing to the determination of every gene’s function in any cell type of the entire organism at any given point in time.
To contribute to the IKMC goals, EUCOMMTOOLS will establish 250 BAC-CreERT2 transgenic mice allowing inducible conditional gene inactivation in most cell types of the organism at any given point in time. Furthermore, EUCOMMTOOLS will establish 3.500 additional, conditionally targeted mouse ES cells to complete the IKMC resource. In addition, various important technological developments will valorise the EUCOMMTOOLS resources: a genetic toolkit for multipurpose usage of the conditional knockout alleles, and improvements of the Cre-recombinase function. The EUCOMMTOOLS Cre transgenic resource as well as its library of conditionally mutated mouse ES cells enables the establishment of mutant mice world-wide in a standardized, cost-effective and time-saving manner, making mouse mutants more easily available to the wider biomedical research community than possible previously. All EUCOMMTOOLS vectors, mutant ES cells and mice will be displayed via the EUCOMMTOOLS web portal and will be distributed by EuMMCR and EMMA to the scientific community.
In general, EUCOMMTOOLS fosters existing European consortia which address mouse functional genomics, mouse mutant phenotyping, and mouse archiving.
Taken together, EUCOMMTOOLS will further advance the functional annotation of the entire mouse genome and thereby enhance the understanding of the molecular basis of disease. Furthermore, it will support drug development by SMEs and the pharmaceutical industry.

Invito a presentare proposte

FP7-HEALTH-2010-single-stage
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Coordinatore

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Indirizzo
Ingolstadter Landstrasse 1
85764 Neuherberg
Germania
Tipo di attività
Research Organisations
Contributo UE
€ 4 717 398,55
Contatto amministrativo
Jürgen Ertel (Dr.)

Partecipanti (10)

GENOME RESEARCH LIMITED
United Kingdom
Contributo UE
€ 4 743 667
Indirizzo
The Gibbs Building, Euston Road 215
NW1 2BE London
Tipo di attività
Research Organisations
Contatto amministrativo
Derek Matthews (Dr.)
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germania
Contributo UE
€ 278 800,93
Indirizzo
Meyerhofstrasse 1
69117 Heidelberg
Tipo di attività
Research Organisations
Contatto amministrativo
Phil Irving (Dr.)
TECHNISCHE UNIVERSITAET DRESDEN
Germania
Contributo UE
€ 568 800
Indirizzo
Helmholtzstrasse 10
01069 Dresden
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Sven Kreigenfeld (Mr.)
CONSIGLIO NAZIONALE DELLE RICERCHE
Italia
Contributo UE
€ 359 604
Indirizzo
Piazzale Aldo Moro 7
00185 Roma
Tipo di attività
Research Organisations
Contatto amministrativo
Assunta Vesce (Ms.)
CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE
Francia
Contributo UE
€ 360 000
Indirizzo
Rue Laurent Fries 1
67404 Illkirch Graffenstaden
Tipo di attività
Research Organisations
Contatto amministrativo
Steve Brooks (Dr.)
UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE

Partecipazione conclusa

Spagna
Contributo UE
€ 589 165,25
Indirizzo
Avenida De La Universidad S-n
03202 Elche
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Rafael Gandía- Balaguer (Mr.)
MEDICAL RESEARCH COUNCIL
United Kingdom
Indirizzo
North Star Avenue Polaris House
SN2 1FL Swindon
Tipo di attività
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Contatto amministrativo
Hilary Gates (Dr.)
UNIVERSIDAD DE MURCIA
Spagna
Contributo UE
€ 160 038,20
Indirizzo
Avenida Teniente Flomesta S/n - Edificio Convalecencia
30003 Murcia
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Maria Sánchez-Merenciano Juárez (Ms.)
MONASH UNIVERSITY
Australia
Contributo UE
€ 222 199,07
Indirizzo
Wellington Road
3800 Victoria
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Silvio Tiziani
THE JACKSON LABORATORY NON PROFIT CORPORATION
Stati Uniti
Indirizzo
Main Street 610
04609 Bar Harbor
Tipo di attività
Other
Contatto amministrativo
Stephen Murray (Dr.)