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The role of the Calcium Sensing Receptor (CaSR) in health and disease, implications for translational medicine

Ziel

The identification of the extracellular calcium sensing receptor (CaSR) was a crucial step in understanding nutrient sensing in mammals. In mammalian organisms the CaSR has multiple roles: besides calcium homeostasis, it is involved in protection against osteoporosis, blood vessel calcification, prevention against colorectal cancer, is involved in metastasis of breast and prostate cancer cells to bone. The proposed ITN will perform basic and multidisciplinary investigations into the role of the CaSR and will provide experimental data for computational modelling. It will use holistic approaches of systems biology to gain knowledge on mechanisms of CaSR function.
We will use intersectoral expertise in revealing the significance of CaSR signalling in cancer, and cardiovascular disease.
The purpose of this ITN is to:
• Educate and train Early Stage Researchers to become excellent scientists, enable them to gain a holistic view of their specific research area, prepare them for the challenges of working in a highly competitive environment, be it in Academia or in Industry.
• Generate a systems biology model for CaSR-dependent signalling in order to find innovative therapeutic approaches and interventions for the natural and synthetic ligands of the CaSR.
• Establish long lasting interdisciplinary and intersectoral cooperation among basic, clinical and applied researchers, working on the CaSR to strengthen the European Research Area.

Being in a research environment that examines the role of one single molecule in many different tissues (e.g. kidney, intestine, blood vessels) and pathologies (cancer and vascular calcification), will increase the awareness of the young researchers for a holistic approach in understanding CaSR-related pathophysiology. Continuous comparison of the function of the CaSR in systems studied by their fellow ESRs, will sensitize the young researchers for the complexities of biomedical research and advantages of multidisciplinarity.

Aufforderung zur Vorschlagseinreichung

FP7-PEOPLE-2010-ITN
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

MC-ITN - Networks for Initial Training (ITN)

Koordinator

MEDIZINISCHE UNIVERSITAET WIEN
Adresse
Spitalgasse 23
1090 Wien
Österreich
Aktivitätstyp
Higher or Secondary Education Establishments
EU-Beitrag
€ 774 032
Kontakt Verwaltung
Hannes Stockinger (Prof.)

Beteiligte (7)

UNIVERSITE DE PICARDIE JULES VERNE
Frankreich
EU-Beitrag
€ 547 079
Adresse
Chemin Du Thil
80025 Amiens
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Romuald Mentaverri (Dr.)
CARDIFF UNIVERSITY
United Kingdom
EU-Beitrag
€ 524 879
Adresse
Newport Road 30-36
CF24 ODE Cardiff
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Eevi Laukkanen (Ms.)
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU-Beitrag
€ 279 509
Adresse
Wellington Square University Offices
OX1 2JD Oxford
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Linda Polik (Ms.)
STICHTING VU
Niederlande
EU-Beitrag
€ 253 585
Adresse
De Boelelaan 1105
1081 HV Amsterdam
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Yvonne Kops (Dr.)
UNIVERSITA DEGLI STUDI DI FIRENZE
Italien
EU-Beitrag
€ 257 355
Adresse
Piazza San Marco 4
50121 Florence
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Giacomo Laffi (Prof.)
ASTRAZENECA UK LIMITED
United Kingdom
EU-Beitrag
€ 279 509
Adresse
1 Francis Crick Avenue Cambridge Biomedical Campus
CB2 0AA Cambridge
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt Verwaltung
Terry Reed (Dr.)
VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG
Niederlande
Adresse
De Boelelaan 1105
1081 HV Amsterdam
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Sa Jansen (Mr.)