Obiettivo
NU-AGE is a large multidisciplinary consortium (30 partners, from 16 EU countries) involving nutritionists, biogerontologists, immunologists and molecular biologists from the most prestigious institutions in Europe, 5 large food industries, 8 traditional food companies and 1 biotech SME, SPES GEIE and FooDrinkEurope, covering the SME Food Industrial Associations of 13 European countries and the European Confederation the food and drink industry. NU-AGE aims are: 1. to counteract the physical/cognitive decline occurring in the elderly as a consequence of the progressive alteration of different organs/systems (immune and cardiovascular systems, bone, brain, muscle and intestine) by one year elderly-tailored whole diet intervention on 1250 healthy elderly men and women aged 65-79 years (half diet, half control) from 5 different EU regions; 2. to assess the effect of the newly designed food pyramid specific for 65+ EU citizens on the different organs/systems using a large set of biomarkers related to nutrition and ageing, with particular attention to the low grade, chronic, systemic inflammatory status named inflammageing, a major risk factor for common age-related diseases; 3. to perform in a subgroup of 120 subjects in depth studies and high throughput “omics” to identify cellular/molecular targets/mechanisms responsible for whole diet effect; 4. to perform genetic and epigenetic studies to assess the role of individual variability on the response to diet; 5. to adopt an integrative comprehensive approach (systems biology) to analyze the whole set of data. The results of dietary intervention will be used to develop elderly-tailored prototypes of functional foods and to improve traditional foods. The research activity will be accompanied and followed by a strong activity of dissemination and industrial exploitation to support EU strategies on nutritional recommendations, thus contributing to the implementation of legislation related to nutritional and health claims for elderly in Europe.
Campo scientifico
Argomento(i)
Invito a presentare proposte
FP7-KBBE-2010-4
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Meccanismo di finanziamento
CP-IP - Large-scale integrating projectCoordinatore
40126 Bologna
Italia
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Partecipanti (33)
Partecipazione conclusa
FI-31600 JOKIOINEN
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NR4 7TJ Norwich
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6708 PB Wageningen
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75007 Paris
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00144 Roma
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T12 YN60 Cork
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NR4 7UQ Norwich
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02 787 Warszawa
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1040 Bruxelles / Brussel
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1040 BRUXELLES
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00790 Helsinki
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11635 Athina
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5032 Gembloux Les Isnes
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RG6 6AH Reading
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17177 Stockholm
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Partecipazione conclusa
00370 Helsinki
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70182 Orebro
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92665 ASNIERES SUR SEINE
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41051 Castelnuovo Rangone
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84013 CAVA DE TIRRENI (SA)
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Partecipazione conclusa
83690 SALERNES
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3454 SITZENBERG REIDLING
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17411 VIDRERES
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39175 MALSICE
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57100 Koyfalia, Thessaloniki
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33090 MERSIN
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2595 DA Den Haag
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63000 Clermont Ferrand
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Partecipazione conclusa
1800 VEVEY
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2730 ALBERTIRSA
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71520 SAINT POINT
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1015 LAUSANNE
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40127 Bologna
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