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Role of Skeletal Stem Cells in Bone Repair

Periodic Report Summary - SKELETAL STEM CELLS (Role of Skeletal Stem Cells in Bone Repair)

The aim of the laboratory is to elucidate the cellular and molecular bases of skeletal regeneration. The skeleton exhibit high regenerative capacities that rely on the recruitment of skeletal stem cells during the early stage of bone repair shortly after bone injury. The origins of these skeletal stem cells remain elusive and most research efforts worldwide concentrate on the regenerative potentials of bone marrow-derived mesenchymal stem cells. The goal of this project is to better characterise the origins of skeletal stem cells, define the skeletal stem cells populations within adult bone and determine how these populations are established during the development and growth of the skeleton.

We focus on a key source of skeletal stem cell within the periosteum, which has been shown by our group and others to largely contribute to skeletal regeneration. We have compared the origins and molecular characteristics of skeletal stem cells within periosteum compared to bone marrow, in order to better understand the bases for the high regenerative potential of periosteum-derived cells. This research will likely lead to better ways to purify skeletal stem cells for cell therapy and will allow to determine the role of skeletal stem cells within bone marrow and periosteum during bone maintenance and regeneration.
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