Final Report Summary - MAXMAP (Developing maximum-resolution genotype-phenotype maps using whole-genome polymorphism data)
The goal of this project was to explore the limits of the GWAS approach using the model plant Arabidopsis thaliana, moving beyond marker-trait linkage disequilibrium to full sequence information. This goal was accomplished as evidenced by two landmark papers (Cell, 2016) describing full genome data for over 1135 lines, and a companion paper that added in data about gene expression and epigenetic regulation in the same set. Other contributions of the project include description of novel statistical methods, and a studies exploring particular features of the data, like variation for genome size.